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Journal of veterinary science2010; 11(2); 173-175; doi: 10.4142/jvs.2010.11.2.173

Autologous conditioned plasma as therapy of tendon and ligament lesions in seven horses.

Abstract: This case report describes the intralesional application of autologous conditioned plasma (ACP) in seven horses as treatment of severe tendinitis of the superficial digital flexor tendon, deep digital flexor tendon, or desmitis of the inferior check ligament. Follow-up data of the horses revealed a positive outcome in 10 to 13 months post injury. All horses treated with ACP were either performing in their previous work-load or were back in full training. Further studies with long-term follow-up will have to be performed to support these clinical intermediate-term observations.
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Publication Date: 2010-05-12 PubMed ID: 20458161PubMed Central: PMC2873820DOI: 10.4142/jvs.2010.11.2.173Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper conducts case studies to examine the therapeutic effects of autologous conditioned plasma (ACP) in horses suffering from severe tendinitis or desmitis. It concludes with the positive results of the ACP treatment, where all the treated horses were able to return to their previous workload or full training between 10 and 13 months after the injury.

Research Objective

  • The main objective of this research was to use autologous conditioned plasma (ACP) treatment on seven horses suffering from severe tendinitis or desmitis and check its effectiveness in assisting their recovery.

Research Methodology

  • The researchers used a case report approach and selected seven horses with severe tendinitis or desmitis. Tendinitis refers to an inflammation of a tendon, while desmitis is the inflammation of a ligament.
  • These horses suffered from severe tendinitis of the superficial digital flexor tendon, the deep digital flexor tendon, or desmitis of the inferior check ligament.
  • ACP, a form of regenerative medicine where the horse’s own plasma is conditioned and injected into the lesion, was applied to the horses.

Research Findings

  • The follow-up data showed positive results with all the horses recovering enough to return to their previous workload or full training.
  • This recovery period ranged from 10 to 13 months post injury.

Research Conclusion

  • The study concluded that the application of ACP is beneficial for horses suffering from serious tendon or ligament lesions, as the treatment assisted the horses in returning to their previous level of physical activity.
  • However, the researchers stressed the need for further studies with long-term follow-up to support these clinical intermediate-term observations.

Cite This Article

APA
Georg R, Maria C, Gisela A, Bianca C. (2010). Autologous conditioned plasma as therapy of tendon and ligament lesions in seven horses. J Vet Sci, 11(2), 173-175. https://doi.org/10.4142/jvs.2010.11.2.173

Publication

Journal of veterinary science
ISSN: 1976-555X
NlmUniqueID: 100964185
Country: Korea (South)
Language: English
Volume: 11
Issue: 2
Pages: 173-175

Researcher Affiliations

Georg, Rindermann
  • Equine Clinic, Faculty of Veterinary Medicine, Freie Universitat Berlin, Oertzenweg 19b, 14163 Berlin, Germany.
Maria, Cislakova
    Gisela, Arndt
      Bianca, Carstanjen

        MeSH Terms

        • Animals
        • Blood Component Transfusion / veterinary
        • Female
        • Horses / injuries
        • Ligaments / injuries
        • Ligaments / pathology
        • Male
        • Platelet-Rich Plasma
        • Tendinopathy / pathology
        • Tendinopathy / therapy
        • Tendinopathy / veterinary

        References

        This article includes 16 references
        1. Appel TR, Pötzsch B, Müller J, von Lindern JJ, Bergé SJ, Reich RH. Comparison of three different preparations of platelet concentrates for growth factor enrichment.. Clin Oral Implants Res 2002 Oct;13(5):522-8.
          pubmed: 12453130doi: 10.1034/j.1600-0501.2002.130512.xgoogle scholar: lookup
        2. Argüelles D, Carmona JU, Climent F, Muñoz E, Prades M. Autologous platelet concentrates as a treatment for musculoskeletal lesions in five horses.. Vet Rec 2008 Feb 16;162(7):208-11.
          pubmed: 18281627doi: 10.1136/vr.162.7.208google scholar: lookup
        3. Bosch G, van Schie HT, de Groot MW, Cadby JA, van de Lest CH, Barneveld A, van Weeren PR. Effects of platelet-rich plasma on the quality of repair of mechanically induced core lesions in equine superficial digital flexor tendons: A placebo-controlled experimental study.. J Orthop Res 2010 Feb;28(2):211-7.
          pubmed: 19714688doi: 10.1002/jor.20980google scholar: lookup
        4. de Mos M, van der Windt AE, Jahr H, van Schie HT, Weinans H, Verhaar JA, van Osch GJ. Can platelet-rich plasma enhance tendon repair? A cell culture study.. Am J Sports Med 2008 Jun;36(6):1171-8.
          pubmed: 18326832doi: 10.1177/0363546508314430google scholar: lookup
        5. Dyson PK, Jackson BF, Pfeiffer DU, Price JS. Days lost from training by two- and three-year-old Thoroughbred horses: a survey of seven UK training yards.. Equine Vet J 2008 Nov;40(7):650-7.
          pubmed: 19165934doi: 10.2746/042516408x363242google scholar: lookup
        6. Fortier LA, Smith RK. Regenerative medicine for tendinous and ligamentous injuries of sport horses.. Vet Clin North Am Equine Pract 2008 Apr;24(1):191-201.
          pubmed: 18314043doi: 10.1016/j.cveq.2007.11.002google scholar: lookup
        7. Künneke A, Jaugstetter H, Heyers P. Bone marrow-autologous conditioned plasma (BM-ACP) beim Pferd -erste klinische Erfahrungen einer neuen, autologen Therapieform bei der Behandlung von Sehnenerkrankungen des Pferdes.. Pferdeheilkunde 2008;24:519–523.
        8. Lam KH, Parkin TD, Riggs CM, Morgan KL. Descriptive analysis of retirement of Thoroughbred racehorses due to tendon injuries at the Hong Kong Jockey Club (1992-2004).. Equine Vet J 2007 Mar;39(2):143-8.
          pubmed: 17378443doi: 10.2746/042516407x159132google scholar: lookup
        9. Marx RE. Platelet-rich plasma: evidence to support its use.. J Oral Maxillofac Surg 2004 Apr;62(4):489-96.
          pubmed: 15085519doi: 10.1016/j.joms.2003.12.003google scholar: lookup
        10. Perkins NR, Reid SW, Morris RS. Profiling the New Zealand Thoroughbred racing industry. 2. Conditions interfering with training and racing.. N Z Vet J 2005 Feb;53(1):69-76.
          pubmed: 15731837doi: 10.1080/00480169.2005.36471google scholar: lookup
        11. Pietrzak WS, Eppley BL. Platelet rich plasma: biology and new technology.. J Craniofac Surg 2005 Nov;16(6):1043-54.
          pubmed: 16327552doi: 10.1097/01.scs.0000186454.07097.bfgoogle scholar: lookup
        12. Rantanen NW, Jorgensen JS, Genovese RL. Ultrasonographic evaluation of the equine limb: Technique.. In: Ross MW, Dyson SJ, editors. Diagnosis and Management of Lameness in the Horse. 1st ed. Philadelphia: Saunders; 2003. pp. 166–188.
        13. Reef VB. Superficial digital flexor tendon healing: ultrasonographic evaluation of therapies.. Vet Clin North Am Equine Pract 2001 Apr;17(1):159-78, vii-viii.
          pubmed: 11488042doi: 10.1016/s0749-0739(17)30081-0google scholar: lookup
        14. Rossdale PD, Hopes R, Digby NJ, offord K. Epidemiological study of wastage among racehorses 1982 and 1983.. Vet Rec 1985 Jan 19;116(3):66-9.
          pubmed: 3976145doi: 10.1136/vr.116.3.66google scholar: lookup
        15. Schnabel LV, Mohammed HO, Miller BJ, McDermott WG, Jacobson MS, Santangelo KS, Fortier LA. Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons.. J Orthop Res 2007 Feb;25(2):230-40.
          pubmed: 17106885doi: 10.1002/jor.20278google scholar: lookup
        16. Sutter WW, Kaneps AJ, Bertone AL. Comparison of hematologic values and transforming growth factor-beta and insulin-like growth factor concentrations in platelet concentrates obtained by use of buffy coat and apheresis methods from equine blood.. Am J Vet Res 2004 Jul;65(7):924-30.
          pubmed: 15281650doi: 10.2460/ajvr.2004.65.924google scholar: lookup

        Citations

        This article has been cited 16 times.
        1. Fantini P, Jiménez R, Vilés K, Iborra A, Palhares MS, Catalán J, Prades M, Miró J. Simple Tube Centrifugation Method for Platelet-Rich Plasma (PRP) Preparation in Catalonian Donkeys as a Treatment of Endometritis-Endometrosis. Animals (Basel) 2021 Oct 9;11(10).
          doi: 10.3390/ani11102918pubmed: 34679937google scholar: lookup
        2. Lange-Consiglio A, Garlappi R, Spelta C, Idda A, Comazzi S, Rizzi R, Cremonesi F. Physiological Parameters to Identify Suitable Blood Donor Cows for Preparation of Platelet Rich Plasma. Animals (Basel) 2021 Aug 4;11(8).
          doi: 10.3390/ani11082296pubmed: 34438754google scholar: lookup
        3. Segabinazzi LGTM, Canisso IF, Podico G, Cunha LL, Novello G, Rosser MF, Loux SC, Lima FS, Alvarenga MA. Intrauterine Blood Plasma Platelet-Therapy Mitigates Persistent Breeding-Induced Endometritis, Reduces Uterine Infections, and Improves Embryo Recovery in Mares. Antibiotics (Basel) 2021 Apr 23;10(5).
          doi: 10.3390/antibiotics10050490pubmed: 33922743google scholar: lookup
        4. Montano C, Auletta L, Greco A, Costanza D, Coluccia P, Del Prete C, Meomartino L, Pasolini MP. The Use of Platelet-Rich Plasma for Treatment of Tenodesmic Lesions in Horses: A Systematic Review and Meta-Analysis of Clinical and Experimental Data. Animals (Basel) 2021 Mar 12;11(3).
          doi: 10.3390/ani11030793pubmed: 33809227google scholar: lookup
        5. Cremonesi F, Bonfanti S, Idda A, Lange-Consiglio A. Platelet Rich Plasma for Regenerative Medicine Treatment of Bovine Ovarian Hypofunction. Front Vet Sci 2020;7:517.
          doi: 10.3389/fvets.2020.00517pubmed: 32903508google scholar: lookup
        6. Canisso IF, Segabinazzi LGTM, Fedorka CE. Persistent Breeding-Induced Endometritis in Mares - a Multifaceted Challenge: From Clinical Aspects to Immunopathogenesis and Pathobiology. Int J Mol Sci 2020 Feb 20;21(4).
          doi: 10.3390/ijms21041432pubmed: 32093296google scholar: lookup
        7. Johnson MD, Sobrino DR, Lewis DD, Shmalberg J. Surgical repair of a proximal patellar tendon avulsion in a dog utilizing triple patellar bone tunnels and modified tendon repair technique. Open Vet J 2018;8(3):256-264.
          doi: 10.4314/ovj.v8i3.5pubmed: 30148078google scholar: lookup
        8. Marini MG, Perrini C, Esposti P, Corradetti B, Bizzaro D, Riccaboni P, Fantinato E, Urbani G, Gelati G, Cremonesi F, Lange-Consiglio A. Effects of platelet-rich plasma in a model of bovine endometrial inflammation in vitro. Reprod Biol Endocrinol 2016 Sep 13;14(1):58.
          doi: 10.1186/s12958-016-0195-4pubmed: 27619959google scholar: lookup
        9. Lange-Consiglio A, Cazzaniga N, Garlappi R, Spelta C, Pollera C, Perrini C, Cremonesi F. Platelet concentrate in bovine reproduction: effects on in vitro embryo production and after intrauterine administration in repeat breeder cows. Reprod Biol Endocrinol 2015 Jun 19;13:65.
          doi: 10.1186/s12958-015-0064-6pubmed: 26084726google scholar: lookup
        10. Brossi PM, Moreira JJ, Machado TS, Baccarin RY. Platelet-rich plasma in orthopedic therapy: a comparative systematic review of clinical and experimental data in equine and human musculoskeletal lesions. BMC Vet Res 2015 Apr 22;11:98.
          doi: 10.1186/s12917-015-0403-zpubmed: 25896610google scholar: lookup
        11. Silva RF, Alvarez ME, Ríos DL, López C, Carmona JU, Rezende CM. Evaluation of the effect of calcium gluconate and bovine thrombin on the temporal release of transforming growth factor beta 1 and platelet-derived growth factor isoform BB from feline platelet concentrates. BMC Vet Res 2012 Nov 6;8:212.
          doi: 10.1186/1746-6148-8-212pubmed: 23131192google scholar: lookup
        12. Carmona JU, López C, Argüelles D. Addressing Heterogeneity in Equine PRP Therapies: A Scoping Review of Methods, Evidence, and Commercial Validation. Animals (Basel) 2025 Dec 13;15(24).
          doi: 10.3390/ani15243586pubmed: 41463871google scholar: lookup
        13. Najeb M, Samy A, Rizk A, Mosbah E, Karrouf G. Regenerative biologics modulating inflammation and promoting tenogenesis in equine superficial digital flexor tendonitis: from molecular pathways to clinical translation. Ir Vet J 2025 Sep 17;78(1):21.
          doi: 10.1186/s13620-025-00309-zpubmed: 40963139google scholar: lookup
        14. Carmona JU, López C. Efficacy of Platelet-Rich Plasma in the Treatment of Equine Tendon and Ligament Injuries: A Systematic Review of Clinical and Experimental Studies. Vet Sci 2025 Apr 18;12(4).
          doi: 10.3390/vetsci12040382pubmed: 40284884google scholar: lookup
        15. Bernardini C, Romagnoli N, Casalini I, Turba ME, Spadari A, Forni M, Gentilini F. Freeze-drying protocols and methods of maintaining the in-vitro biological activity of horse platelet lysate. Int J Vet Sci Med 2024;12(1):71-80.
          doi: 10.1080/23144599.2024.2380586pubmed: 39119550google scholar: lookup
        16. Pérez Fraile A, González-Cubero E, Martínez-Flórez S, Olivera ER, Villar-Suárez V. Regenerative Medicine Applied to Musculoskeletal Diseases in Equines: A Systematic Review. Vet Sci 2023 Nov 23;10(12).
          doi: 10.3390/vetsci10120666pubmed: 38133217google scholar: lookup
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