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Journal of the American Veterinary Medical Association2013; 242(7); 992-996; doi: 10.2460/javma.242.7.992

Babesia equi-induced anemia in a Quarter Horse and subsequent regulatory response.

Abstract: A 7-year-old Quarter Horse gelding used for unsanctioned racing was examined because of fever and anorexia. Results: Physical examination revealed fever, tachycardia, and tachypnea. Results of a CBC indicated anemia and mild thrombocytopenia. Results of microscopic examination of a blood smear indicated piroplasms in erythrocytes, consistent with Babesia spp. Regulatory authorities were contacted, and results of serologic testing at the National Veterinary Services Laboratories confirmed acute Babesia equi infection. Results: Equids on the home premises of the index horse were placed under quarantine. Those equids were tested for piroplasmosis, and 6 of 63 horses had positive results for B equi. Another horse that had previously been housed on the index premises also had positive results for B equi. Competent tick vectors for piroplasmosis organisms were not identified. All 8 horses with piroplasmosis were Quarter Horses that participated in unsanctioned racing and were trained by the same person. Two of the horses were illegally removed from the index premises; these 2 horses and the other horse with piroplasmosis that was previously housed on the index premises could not be found. The other 5 horses with piroplasmosis were euthanized. Investigators concluded that transmission of B equi among horses was most likely iatrogenic. Conclusions: The United States has been considered piroplasmosis free. However, veterinarians should consider piroplasmosis in horses with signalments and clinical signs similar to those of the index horse of this report. Regulatory authorities should be contacted regarding horses in which piroplasmosis is suspected.
Publication Date: 2013-03-23 PubMed ID: 23517213DOI: 10.2460/javma.242.7.992Google Scholar: Lookup
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Summary

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The research article outlines a case study of a horse with an infection of Babesia equi causing anemia. The regulatory responses and implications of the infection on the local horse population are also examined.

Case Description and Diagnosis

  • This case involves a 7-year-old Quarter Horse gelding that exhibited symptoms of fever and anorexia.
  • Upon examination, the horse showed symptoms such as increased heartbeat (tachycardia) and rapid breathing (tachypnea).
  • The horse had anemia and mild thrombocytopenia (low platelets) as echoed in the Complete Blood Count (CBC) results.
  • Blood smear microscopy indicated the presence of piroplasms in red blood cells, suggesting infection by Babesia spp.

Regulatory Interaction and Confirmation tests

  • Upon suspecting a Babesia spp. infection, regulatory authorities were notified for further consultation and confirmation tests.
  • Samples were sent to the National Veterinary Services Laboratories where the acute infection of Babesia equi was confirmed.

Quarantine and Examination of Other Horses

  • The remaining horses in the home range of the infected horse were quarantined as a precautionary measure.
  • These quarantined horses also underwent testing for piroplasmosis, resulting in 6 out of 63 showing positive results for B. equi.
  • Another horse, that was previously housed at the ranch, also tested positive for B. equi.

Possible Mode of Transmission

  • Despite searching, no competent tick vectors (commonly responsible for piroplasmosis) were found, leading the investigators to suspect that the infection most likely spread through iatrogenic means – possibly due to the contaminated equipment or improper practices used by the same trainer of all affected horses.

Implications and Actions

  • Two horses which tested positive had been illicitly removed from the premises and were untraceable, along with another ex-housed horse who tested positive. The remaining five horses were euthanized to prevent further transmission.
  • This outbreak was noteworthy as the United States was previously considered free of piroplasmosis.
  • This case leads to the emphasis on greater clinical suspicion of piroplasmosis in horses with similar symptoms and medical history, and immediate consultation with regulatory authorities if suspected.
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Cite This Article

APA
Beard LA, Pelzel AM, Rush BR, Wright AM, Galgut BI, Hennager SG, King AO, Traub-Dargatz JL. (2013). Babesia equi-induced anemia in a Quarter Horse and subsequent regulatory response. J Am Vet Med Assoc, 242(7), 992-996. https://doi.org/10.2460/javma.242.7.992

Publication

ISSN: 1943-569X
NlmUniqueID: 7503067
Country: United States
Language: English
Volume: 242
Issue: 7
Pages: 992-996

Researcher Affiliations

Beard, Laurie A
  • Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA. lbeard@vet.k-state.edu
Pelzel, Angela M
    Rush, Bonnie R
      Wright, Abra M
        Galgut, Bradley I
          Hennager, Steven G
            King, Alison O
              Traub-Dargatz, Josie L

                MeSH Terms

                • Anemia / etiology
                • Anemia / microbiology
                • Anemia / veterinary
                • Animals
                • Babesia / classification
                • Babesiosis / complications
                • Babesiosis / microbiology
                • Babesiosis / veterinary
                • Horse Diseases / etiology
                • Horse Diseases / microbiology
                • Horse Diseases / pathology
                • Horses
                • Male
                • Running
                • Sports

                Citations

                This article has been cited 4 times.
                1. Ren F, Liu Y, Niu J, Song Y, Cheng H, Zhao C, Cui J, Chen Y, Bai Y, Rao H, Yu J. Prevalence and genetic diversity of Babesia microti in rodents from central and southern Shanxi, China. Parasit Vectors 2025 Jun 22;18(1):236.
                  doi: 10.1186/s13071-025-06898-6pubmed: 40545533google scholar: lookup
                2. Liu Y, Niu J, Cui J, Rao H, Yu J. Prevalence and molecular detection of Babesia microti in rodents in Southeastern Shanxi, China. PLoS One 2024;19(7):e0306181.
                  doi: 10.1371/journal.pone.0306181pubmed: 38959227google scholar: lookup
                3. Schwarz ER, Long MT. Comparison of West Nile Virus Disease in Humans and Horses: Exploiting Similarities for Enhancing Syndromic Surveillance. Viruses 2023 May 24;15(6).
                  doi: 10.3390/v15061230pubmed: 37376530google scholar: lookup
                4. Tirosh-Levy S, Gottlieb Y, Fry LM, Knowles DP, Steinman A. Twenty Years of Equine Piroplasmosis Research: Global Distribution, Molecular Diagnosis, and Phylogeny. Pathogens 2020 Nov 8;9(11).
                  doi: 10.3390/pathogens9110926pubmed: 33171698google scholar: lookup