Biofluid Markers of Equine Neurological Disorders Reviewed From Human Perspectives.

The research article focuses on potential approaches in diagnosing equine neurological disorders (NDs) using advances in human disease diagnosis, particularly with biofluid biomarkers.

Understanding Equine Neurological Disorders

• The paper begins by providing an overview of equine neurological disorders (NDs), highlighting their devastating impacts on horses. NDs in horses often lead to the fatal outcome or euthanasia due to the severity of symptoms. The current methods of diagnosing these disorders rely heavily on clinical signs, differential diagnoses, analysis of cerebrospinal fluid, assessment of histopathological lesions, and imaging.

Human Biofluid Biomarkers and their Potential

• The paper highlights the recent advances in the use of biofluid biomarkers for diagnosing human neurological diseases. Such biomarkers are substances in bodily fluids, like blood or cerebrospinal fluid, that may indicate the presence of a disease.
• The potential for these biomarkers in diagnosing human diseases is then explored, with a suggestion of their possible application to equine NDs.

Transferability of Human Neurobiomarkers to Equine ND Diagnostics

• The core of the review delves into the description of the established human blood and cerebrospinal fluid (CSF) neurobiomarkers that could potentially be applied to diagnosing equine NDs.
• This application is justified by the fact that horses and humans share similar physiological and pathological conditions, and the research is aimed at studying whether biomarkers identified in human patients can be used in equine diagnoses as well.

Objective and Scope

• This paper aims not only to explore the potential use of human neurobiomarkers in equine NDs, but also to ignite further research in this area.
• The scope of this paper covers established human biofluid biomarkers, and doesn’t go into potentially developing new biomarkers for equine NDs.