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Bioengineering (Basel, Switzerland)2026; 13(2); 213; doi: 10.3390/bioengineering13020213

Bridging Species with AI: A Cross-Species Deep Learning Model for Fracture Detection and Beyond.

Abstract: Fractures are a leading cause of morbidity and mortality in Thoroughbred racehorses, posing a significant threat to their welfare and careers. This study introduces a deep learning model specifically designed to facilitate fracture detection in equine athletes. By leveraging extensive training on human fracture data and refining the model with equine imaging, it highlights the transformative potential of transfer learning across species and medical contexts. This approach is not limited to equine fractures but could be adapted for use in detecting injuries or conditions in other veterinary species and even human healthcare applications. A comprehensive databank of radiographs, sourced from public archives and equine hospitals, was curated to encompass diverse conditions (fracture and non-fracture), ensuring robust pattern recognition. The architecture integrates a Vision Transformer for global context modelling with a ResNet backbone and loss function to optimize local feature extraction and cross-species adaptability. The pipeline achieved 96.7% accuracy for modality classification, 97.2% accuracy for projection recognition, and fracture localization intersection over union values of 0.71-0.84 across equine datasets. This work bridges advancements in human and veterinary medicine, opening pathways for AI-driven solutions that extend beyond fractures, fostering improved diagnostic precision and broader applications across species (felines, canines, etc.). By integrating advanced imaging techniques with AI, this study aims to set a foundation for more comprehensive and versatile health monitoring systems.
Publication Date: 2026-02-13 PubMed ID: 41749752PubMed Central: PMC12938560DOI: 10.3390/bioengineering13020213Google Scholar: Lookup
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  • Journal Article

Summary

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Overview

  • This study developed a deep learning model that uses knowledge from human fracture detection to identify fractures in Thoroughbred racehorses, demonstrating how AI techniques can be adapted across different species to improve veterinary and potentially human healthcare diagnostics.

Introduction and Research Motivation

  • Fractures cause significant health risks and career impacts for Thoroughbred racehorses, making early and accurate fracture detection critical for their welfare.
  • The study aims to address this by applying deep learning techniques to radiographic images to enhance fracture detection capabilities for equine athletes.
  • The researchers leveraged the similarities between human and equine bone structures to use transfer learning, where a model trained on human fracture data is adapted for equine fracture detection.
  • This cross-species approach also hints at future broader applications across different animal species as well as human medical diagnostics.

Data Collection and Preparation

  • Amassed a comprehensive databank of radiographic images from a variety of sources including public archives and equine hospitals, containing both fracture and non-fracture cases.
  • The dataset was curated to be diverse representing different imaging modalities and projections, which enhances the model’s ability to recognize patterns consistently across conditions and image types.

Model Architecture and Methodology

  • Combined advanced deep learning components:
    • A Vision Transformer (ViT), which captures global contextual information across the entire image, helping the model understand overall bone structure and relations.
    • A ResNet backbone, known for robust local feature extraction, to focus on detailed aspects of fracture sites.
    • Specialized loss functions tailored to optimize both local feature detection and the ability to generalize across species.
  • The integration of these components allows the model to effectively detect fractures while adapting knowledge from human radiographs to equine images.

Performance and Results

  • The system achieved:
    • 96.7% accuracy in identifying imaging modality types (e.g., X-rays, projections).
    • 97.2% accuracy in recognizing the image projection, enabling better contextual interpretation.
    • Fracture localization performance with intersection over union (IoU) values between 0.71 and 0.84 in equine radiographs, indicating precise detection and region localization of fractures.
  • These metrics demonstrate the model’s strong capacity for accurate and reliable fracture detection in equine medical imaging.

Implications and Future Applications

  • The study exemplifies how AI models trained in one species (humans) can be successfully adapted to another (horses), opening new paths for cross-species medical AI applications.
  • Beyond equine fracture detection, the approach could be extended to diagnose various injuries or medical conditions in other veterinary species like felines and canines, improving veterinary diagnostic efficiency and outcomes.
  • It also suggests potential for transfer learning to benefit human healthcare applications by enriching diagnostic tools with insights learned from veterinary medicine.
  • Integrating such AI models with advanced imaging techniques fosters the development of comprehensive, versatile health monitoring platforms that could revolutionize diagnostics by increasing precision and allowing for more proactive healthcare management.

Conclusion

  • This research bridges human and veterinary medicine by developing a cross-species AI model for fracture detection that is highly accurate and adaptable.
  • The combination of global and local imaging feature extraction techniques enables the model to successfully translate learning across diverse biological and imaging contexts.
  • These innovations lay a foundation for broader multi-species diagnostic tools that leverage AI to improve health outcomes in animals and humans alike.

Cite This Article

APA
Ahmed HT, Berner D, Zhang Q, Verheyen K, Llabres-Diaz F, Peter VG, Chang YM. (2026). Bridging Species with AI: A Cross-Species Deep Learning Model for Fracture Detection and Beyond. Bioengineering (Basel), 13(2), 213. https://doi.org/10.3390/bioengineering13020213

Publication

ISSN: 2306-5354
NlmUniqueID: 101676056
Country: Switzerland
Language: English
Volume: 13
Issue: 2
PII: 213

Researcher Affiliations

Ahmed, Hanya T
  • Department of Comparative Biomedical Sciences, Royal Veterinary College, London NW1 0TU, UK.
Berner, Dagmar
  • Department of Clinical Science and Services, Royal Veterinary College, London NW1 0TU, UK.
Zhang, Qianni
  • School of Electronic Engineering and Computer Science, Queen Mary University of London, London E1 4NS, UK.
Verheyen, Kristien
  • Department of Pathobiology and Population Sciences, Royal Veterinary College, London NW1 0TU, UK.
Llabres-Diaz, Francisco
  • Department of Clinical Science and Services, Royal Veterinary College, London NW1 0TU, UK.
Peter, Vanessa G
  • Veterinary Diagnostic Imaging, Rossdales Equine Hospital & Diagnostic Centre, Newmarket CB8 7NN, UK.
Chang, Yu-Mei
  • Department of Comparative Biomedical Sciences, Royal Veterinary College, London NW1 0TU, UK.

Grant Funding

  • vet/prj/810 (2023) / Horserace Betting Levy Board

Conflict of Interest Statement

The authors declare no conflict of interest.

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