Cardiovascular effects and fatalities associated with intravenous administration of doxycycline to horses and ponies.
Abstract: Intravenous use of doxycycline in horses is associated with deleterious side effects on the cardiovascular system which may result in fatalities. At dosages and infusion rates used in these studies, supraventricular tachycardia, systemic arterial hypertension, clinical signs of discomfort, collapse and death were observed. Results of the present study suggest that the intravenous use of doxycycline should be avoided in horses.
Publication Date: 1992-01-01 PubMed ID: 1555539DOI: 10.1111/j.2042-3306.1992.tb02777.xGoogle Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research article discusses the harmful cardiovascular effects and potential fatalities caused by the intravenous use of the antibiotic doxycycline in horses and ponies.
Introduction to Research
- The paper explores the adverse side effects on the cardiovascular system observed in horses and ponies upon intravenous administration of doxycycline, an antibiotic commonly used in veterinary medicine.
- The research aims to provide a clear understanding of the potential dangers and risks associated with this treatment method, considering the welfare of the animals and providing insight for safer applications of medication.
Methodology
- The study made use of certain dosages and infusion rates of doxycycline to evaluate their effects on the subjects.
- Observations during the study were made, with an emphasis on systemic arterial hypertension, supraventricular tachycardia (a type of abnormal heart rhythm), visible signs of discomfort, the possibility of collapse, and finally death.
Findings and Results
- The research confirms a direct association between the intravenous administration of doxycycline and harmful cardiovascular effects.
- These effects included the observed supraventricular tachycardia, systematic arterial hypertension, evident discomfort and even incidences of collapse in horses.
- In some extreme cases, the side effects of this treatment led to the fatality of the subjects.
Conclusion
- Based on the deleterious effects discovered in the study, the research recommends against the intravenous use of doxycycline in horses and ponies.
- This conclusion is made with the ultimate goal of ensuring the health and safety of these animals in veterinary practices.
Cite This Article
APA
Riond JL, Riviere JE, Duckett WM, Atkins CE, Jernigan AD, Rikihisa Y, Spurlock SL.
(1992).
Cardiovascular effects and fatalities associated with intravenous administration of doxycycline to horses and ponies.
Equine Vet J, 24(1), 41-45.
https://doi.org/10.1111/j.2042-3306.1992.tb02777.x Publication
Researcher Affiliations
- Department of Anatomy, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
MeSH Terms
- Animals
- Blood Pressure / drug effects
- Cardiovascular System / drug effects
- Doxycycline / administration & dosage
- Doxycycline / adverse effects
- Electrocardiography / veterinary
- Electrolytes / blood
- Female
- Heart / drug effects
- Heart Rate / drug effects
- Horses / physiology
- Infusions, Intravenous / veterinary
- Male
- Muscles / drug effects
- Respiration / drug effects
Citations
This article has been cited 6 times.- Chapuis RJJ, Smith JS, French HM, Toka FN, Peterson EW, Little EL. Nonlinear Mixed-Effect Pharmacokinetic Modeling and Distribution of Doxycycline in Healthy Female Donkeys after Multiple Intragastric Dosing-Preliminary Investigation. Animals (Basel) 2021 Jul 9;11(7).
- Turk E, Corum O, Tekeli IO, Sakin F, Uney K. Effects of Single and Repeated Doses on Disposition and Kinetics of Doxycycline Hyclate in Goats. Animals (Basel) 2020 Jun 24;10(6).
- Zozaya H, Gutierrez L, Bernad MJ, Sumano H. Pharmacokinetics of a peroral single dose of two long-acting formulations and an aqueous formulation of doxycycline hyclate in horses. Acta Vet Scand 2013 Mar 8;55(1):21.
- El-Neweshy MS. Experimental doxycycline overdose in rats causes cardiomyopathy. Int J Exp Pathol 2013 Apr;94(2):109-14.
- Hu T, Zhou T, Goit RK, Tam KC, Chan YK, Lam WC, Lo ACY. Bioactive Glial-Derived Neurotrophic Factor from a Safe Injectable Collagen-Alginate Composite Gel Rescues Retinal Photoreceptors from Retinal Degeneration in Rabbits. Mar Drugs 2024 Aug 30;22(9).
- Martínez J, Escudero E, Badillo E, Yuste MT, Galecio JS, Marin P. Pharmacokinetics of Doxycycline in Plasma and Milk after Intravenous and Intramuscular Administration in Dairy Goats. Animals (Basel) 2024 Aug 20;14(16).
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
