Cardiovascular effects of romifidine in the standing horse.
Abstract: The cardiovascular effects of romifidine, an alpha-2 adrenoreceptor agonist, were investigated in six horses using two doses (80 and 120 microg kg(-1)) in a cross-over study design. Cardiac index and mixed venous oxygenation were significantly decreased at 15 and 30 minutes after both doses of romifidine. Systemic vascular resistance was significantly increased with romifidine (120 microg kg(-1)). Arterial blood pressure increased initially and then gradually decreased; the doses of decrease was significant at 90 and 120 minutes with romifidine 80 and 120 microg kg(-1). There were minimal differences between the two doses of romifidine, and both should be used with care especially in horses with cardiovascular compromise, or when used in combination with other cardiovascular depressant drugs.
Copyright 2002 Published by Elsevier Science Ltd.
Publication Date: 2002-05-25 PubMed ID: 12027592DOI: 10.1053/rvsc.2001.0533Google Scholar: Lookup
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- Clinical Trial
- Journal Article
Summary
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This study investigates the cardiovascular effects of the drug romifidine on horses. It found that this drug significantly decreased heart function and blood oxygen levels while increasing blood pressure and systemic vascular resistance.
Study Design and Methodology
- The researchers conducted a cross-over study, a type of study where participants receive different treatments in a random sequence, over time.
- They used two different dosages of romifidine on six horses. The two doses were 80 and 120 micrograms per kilogram.
Findings
- The effect of romifidine was tested by examining the cardiac index (a measure of heart function) and mixed venous oxygenation (oxygen level in the venous blood). Both of these measures decreased significantly at 15 and 30 minutes after administering both doses of the drug.
- The systemic vascular resistance, which is the resistance that must be overcome to push blood through the circulatory system, increased significantly with the higher dose of romifidine (120 micrograms per kilogram).
- Arterial blood pressure increased initially after administering the drug but then gradually decreased over time. The decrease was significant at 90 and 120 minutes for both the 80 and 120 micrograms per kilogram dosages of romifidine.
Implications
- There were only minimal differences between the effects of the two doses of romifidine. This suggests that increasing the dosage does not dramatically alter the drug’s impact on the cardiovascular system.
- The results indicate that romifidine affects the cardiovascular system and should be used with caution, particularly in horses with heart problems.
- Additionally, the drug should not be used alongside other drugs that depress the cardiovascular system, as there could be enhanced adverse effects due to drug interactions.
Conclusions
- This study provides crucial information about the cardiovascular effects of romifidine in horses and raises vital concerns about its usage, particularly in horses with existing cardiovascular problems or when used with other cardiovascular depressant drugs.
Cite This Article
APA
Freeman SL, Bowen IM, Bettschart-Wolfensberger R, Alibhai HI, England GC.
(2002).
Cardiovascular effects of romifidine in the standing horse.
Res Vet Sci, 72(2), 123-129.
https://doi.org/10.1053/rvsc.2001.0533 Publication
Researcher Affiliations
- Department of Farm Animal and Equine Medicine and Surgery, Royal Veterinary College, Hawkshead lane, N.Mymms, Hatfield, Herts, AL9 7TA, UK. sfreeman@rvc.ac.uk
MeSH Terms
- Animals
- Blood Chemical Analysis
- Blood Pressure / drug effects
- Cross-Over Studies
- Dose-Response Relationship, Drug
- Heart Rate / drug effects
- Hemodynamics / drug effects
- Horses / physiology
- Imidazoles / administration & dosage
- Imidazoles / adverse effects
- Imidazoles / pharmacology
- Pulmonary Wedge Pressure / drug effects
- Vascular Resistance / drug effects
Citations
This article has been cited 4 times.- Cowling N, Woldeyohannes S, Sole Guitart A, Goodwin W. Measurement of Tissue Oximetry in Standing Unsedated and Sedated Horses.. Vet Sci 2021 Sep 22;8(10).
- Romagnoli N, Al-Qudah KM, Armorini S, Lambertini C, Zaghini A, Spadari A, Roncada P. Pharmacokinetic profile and partitioning in red blood cells of romifidine after single intravenous administration in the horse.. Vet Med Sci 2017 Nov;3(4):187-197.
- Nannarone S, Gialletti R, Veschini I, Bufalari A, Moriconi F. The use of alpha-2 agonists in the equine practice: comparison between three molecules.. Vet Res Commun 2007 Aug;31 Suppl 1:309-12.
- Marntell S, Nyman G, Funkquist P. Dissociative anaesthesia during field and hospital conditions for castration of colts.. Acta Vet Scand 2006;47(1):1-11.
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