Cell-based therapies: current issues and future directions.
Abstract: This article focuses on current issues facing cell-based therapies in equine practice and future studies validating the use of stem cells and related biologic therapies for the treatment of musculoskeletal conditions in the horse. Issues raised include the characterization and use of tissue- and anatomic location-specific mesenchymal stem cell (MSC) sources, the putative advantages and feasibility of allogeneic embryonic stem cell and MSC products, the technical advantages and performance of cell-based biologic agents that do not require extensive ex vivo manipulation, the regulation of MSC homing, potential nonorthopaedic stem cell applications, and the logistics required to demonstrate cell-based therapy efficacy in horses.
Copyright © 2011 Elsevier Inc. All rights reserved.
Publication Date: 2011-08-30 PubMed ID: 21872767DOI: 10.1016/j.cveq.2011.07.001Google Scholar: Lookup
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- Journal Article
Summary
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The research article is about the current challenges and potential future advancements in using cell-based therapies to treat musculoskeletal ailments in horses. It delves into topics like stem cell sources, embryonic stem cell and mesenchymal stem cell use, cell-based agents, regulation of stem cell homing, and nonorthopedic applications.
Cell Source Characterization
- The study discusses the importance of identifying tissue-specific and anatomical location-specific mesenchymal stem cell (MSC) sources. The authors suggest that the therapeutic outcomes of cell-based therapies might change depending on the source of the stem cells used in treatment.
Favorability and Feasibility of Allogeneic Embryonic Stem Cells and MSC products
- It deliberates the potential benefits and implications of using allogeneic (belonging to the same species but genetically different) embryonic stem cells and MSC products in therapy. This exploration may open up new possibilities for equine therapy involving stem cells.
Cell-based Biologic Agents
- The paper highlights the functional advantages and operating efficiencies of cell-based biologic agents that do not require significant ex vivo (out of the living organism) manipulation. This could have implications for the development and cost of cell-based therapies in the future.
Regulation of MSC Homing
- The research examines the control and regulation of MSC homing – the mechanism by which stem cells migrate to the sites of injury/lesion to exert their therapeutic effects. Gaining more information on this process could help improve the efficiency of cell-based therapies.
Nonorthopaedic Stem Cell Applications
- The authors also explore potential nonorthopaedic uses for stem cell therapies, suggesting that these cells could have a wider range of applications beyond treating musculoskeletal conditions.
Demonstrating Therapy Efficacy
- Finally, the article discusses the logistics involved in demonstrating the effectiveness of cell-based therapies in horses. This includes the planning and execution of thorough studies and experiments designed to validate the claims of cell therapy efficacy.
Cite This Article
APA
Stewart MC.
(2011).
Cell-based therapies: current issues and future directions.
Vet Clin North Am Equine Pract, 27(2), 393-399.
https://doi.org/10.1016/j.cveq.2011.07.001 Publication
Researcher Affiliations
- Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, 1008 West Hazelwood Drive, Urbana, IL 61802, USA. matt1@illinois.edu
MeSH Terms
- Animals
- Horse Diseases / therapy
- Horses
- Stem Cell Transplantation / veterinary
- Stem Cells / physiology
- Treatment Outcome
- Veterinary Medicine / trends
Citations
This article has been cited 3 times.- Smolinska V, Csobonyeiova M, Zamborsky R, Danisovic L. Stem Cells and Their Derivatives: An Implication for the Regeneration of Nonunion Fractures. Cell Transplant 2023 Jan-Dec;32:9636897231183530.
- Smolinska V, Debreova M, Culenova M, Csobonyeiova M, Svec A, Danisovic L. Implication of Mesenchymal Stem Cells and Their Derivates for Osteochondral Regeneration. Int J Mol Sci 2022 Feb 24;23(5).
- Gugjoo MB, Fazili MR, Gayas MA, Ahmad RA, Dhama K. Animal mesenchymal stem cell research in cartilage regenerative medicine - a review. Vet Q 2019 Dec;39(1):95-120.
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