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Home / Equine Research Bank / Vet Sci / Chronic Progressive Lymphedema in Belgian Draft Horses: Unde...
Veterinary sciences2023; 10(5); doi: 10.3390/vetsci10050347

Chronic Progressive Lymphedema in Belgian Draft Horses: Understanding and Managing a Challenging Disease.

Abstract: Chronic progressive lymphedema (CPL) in draft horses is characterized by increased dermal thickness and fibrosis, with the development of skinfolds and nodules, hyperkeratosis, and ulcerations on the distal limbs of affected horses. Secondary bacterial, fungal, or parasitic infections frequently complicate and aggravate the lesions, as well as the progression of this disease. CPL has a particularly high prevalence of up to 85.86% in the Belgian draft horse breed. Due to the disease's progressive and incurable nature, affected horses are often euthanized prematurely. The treatment options are solely symptomatic, aimed at improving the horse's quality of life. Despite the severity of this condition, many uncertainties about its etiology and pathogenesis still remain to date. The established scientific research on CPL is rather limited, although there is an urgent need for strategies to tackle this disease. This review summarizes the available knowledge, serving as a guideline for practitioners, and provides perspectives for future research programs.
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Publication Date: 2023-05-12 PubMed ID: 37235431PubMed Central: PMC10222719DOI: 10.3390/vetsci10050347Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study is about the chronic progressive lymphedema (CPL), a painful and incurable disease afflicting Belgian draft horses, which is characterized by increased skin thickness and fibrosis, amongst others. The research seeks to shed light on the disease’s characteristics, the available treatment options, and outlines potential paths for future study.

Chronic Progressive Lymphedema in Belgian Draft Horses

  • The research centers on Chronic Progressive Lymphedema (CPL), a disease that predominantly affects Belgian draft horses. The disease is known for causing an increase in dermal thickness and fibrosis which leads to the development of skinfolds and nodules, hyperkeratosis (an increase in the skin’s keratin layer), and ulcerations on the lower limbs of the horses.
  • The disease can become more complicated and severe due to secondary infections from bacteria, fungi, or parasites which aggravate the lesions and speed up the progression of the disease.
  • Interestingly, the breed that seems to be most affected by this disease is the Belgian draft horse, with a prevalence rate of up to 85.86%, which is alarmingly high.

Treatment and Management of CPL

  • Due to the progressive and incurable nature of CPL, horses affected by it are often euthanized prematurely. This is done mostly because the condition negatively impacts the quality of life of these horses.
  • Current treatment options are focusing on managing the symptoms of the disease, mainly to improve the quality of life for the horse. The study does not provide specifics on these treatment options but suggests they are limited and purely symptomatic.

Research on CPL and Future Perspectives

  • The research piece clearly identifies that despite the severity and high prevalence of the disease, there is still much to learn. Numerous uncertainties remain around the causes (etiology) and the development (pathogenesis) of the disease.
  • Scientific research on CPL is limited, but as the research article suggests, there is an urgent need for it due to the damaging impact of the disease.
  • The researchers aim to provide a thorough review of the available knowledge on CPL, serving as a guideline for those treating it and raising points of interest for future research programs. The hope is that these research programs will ultimately lead to a breakthrough in preventing or curing CPL.

Cite This Article

APA
Brys M, Claerebout E, Chiers K. (2023). Chronic Progressive Lymphedema in Belgian Draft Horses: Understanding and Managing a Challenging Disease. Vet Sci, 10(5). https://doi.org/10.3390/vetsci10050347

Publication

Veterinary sciences
ISSN: 2306-7381
NlmUniqueID: 101680127
Country: Switzerland
Language: English
Volume: 10
Issue: 5

Researcher Affiliations

Brys, Marieke
  • Laboratory of Veterinary Pathology, Department of Pathobiology, Pharmacology and Zoological Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Claerebout, Edwin
  • Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Chiers, Koen
  • Laboratory of Veterinary Pathology, Department of Pathobiology, Pharmacology and Zoological Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.

Conflict of Interest Statement

The authors declare no conflict of interest.

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