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Home / Equine Research Bank / Animals (Basel) / Clinical Effects of the Extract of the Seeds of the Indian C...
Animals : an open access journal from MDPI2019; 9(8); doi: 10.3390/ani9080585

Clinical Effects of the Extract of the Seeds of the Indian Celery-Apium Graveolens-In Horses Affected by Chronic Osteoarthritis.

Abstract: The extract of the seeds from Indian celery, Apium greaveolens (CSE), tested in experimental animals (rodents), and in humans affected by chronic osteoarthritic diseases, exhibits anti-inflammatory effects that can be compared, to some degree, to those of non-steroid anti-inflammatory drugs (NSAID). In view of a potential use of CSE in the equine species, it was tested on horses affected by chronic articular pathologies. The trial was performed on 20 horses divided into three different groups, orally treated with 0 (controls), 7.0 or 30 g of CSE BID. Basic orthopedic examinations were conducted, vital signs were observed, and blood samples collected. Improvement was observed at the highest dosage tested (30 g of CSE BID), as reflected in the score values of three clinical parameters, (i) amplitude and (ii) sensitivity to passive flexion and (iii) flexion test. Since the improvement of these parameters can be correlated with a lower perception of the pain, the present data suggest that the CSE treatment can have an analgesic effect in horses affected by chronic osteoarthritic diseases.
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Publication Date: 2019-08-20 PubMed ID: 31434330PubMed Central: PMC6720213DOI: 10.3390/ani9080585Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research explores the effect of Indian Celery Seed Extract (CSE) on horses with chronic osteoarthritis, suggesting that large doses might significantly aid in pain management similar to non-steroidal anti-inflammatory drugs (NSAIDs).

Objective of the Research

  • The research aims to delve into the potential use of Indian Celery Seed Extract (CSE), already known for its anti-inflammatory effects in rodents and humans, for treating chronic joint diseases in horses.

Methodology

  • A total of 20 horses with persistent joint afflictions were split into three different groups. They were given oral doses of either 0 (control group), 7.0, or 30 grams of CSE twice a day.
  • Fundamental orthopedic examinations were conducted, and the horses’ vital signs were observed along with the collection of blood samples for analysis.

Findings

  • The researchers observed a measurable improvement in the group administered the highest dosage of CSE (30 grams, twice daily).
  • This improvement was observed in the amplitude and sensitivity to passive flexion, along with the optional flexion test results. These parameters significantly relate to the perception of pain, and their improvement suggests reduced discomfort in the horses.

Conclusion

  • The study concludes that CSE treatment might have considerable analgesic (pain-relieving) effect in horses suffering from chronic osteoarthritic diseases, similar to the effects of NSAIDs in human treatments. This finding may forward new possibilities for more natural and less invasive treatment for equine chronic osteoarthritis. However, further research is needed to verify the results and calculate the optimal dosages.

Cite This Article

APA
Battaglia B, Angelone M, Vera E, Basini G, Bussolati S, Paci M, Bue MD, Aldigeri R, Grolli S, Quintavalla F, Ramoni R. (2019). Clinical Effects of the Extract of the Seeds of the Indian Celery-Apium Graveolens-In Horses Affected by Chronic Osteoarthritis. Animals (Basel), 9(8). https://doi.org/10.3390/ani9080585

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 9
Issue: 8

Researcher Affiliations

Battaglia, Beatrice
  • Dipartimento Scienze Medico Veterinarie, Università di Parma, Via del taglio 10, 43126 Parma, Italy.
Angelone, Mario
  • Dipartimento Scienze Medico Veterinarie, Università di Parma, Via del taglio 10, 43126 Parma, Italy.
Vera, Elena
  • Dipartimento Scienze Medico Veterinarie, Università di Parma, Via del taglio 10, 43126 Parma, Italy.
Basini, Giuseppina
  • Dipartimento Scienze Medico Veterinarie, Università di Parma, Via del taglio 10, 43126 Parma, Italy.
Bussolati, Simona
  • Dipartimento Scienze Medico Veterinarie, Università di Parma, Via del taglio 10, 43126 Parma, Italy.
Paci, Massimiliano
  • Dipartimento Scienze Medico Veterinarie, Università di Parma, Via del taglio 10, 43126 Parma, Italy.
Bue, Maurizio Del
  • Dipartimento Scienze Medico Veterinarie, Università di Parma, Via del taglio 10, 43126 Parma, Italy.
Aldigeri, Raffaella
  • Dipartimento di Medicina e Chirurgia, Università di Parma, Via Gramsci 14, 43126 Parma, Italy.
Grolli, Stefano
  • Dipartimento Scienze Medico Veterinarie, Università di Parma, Via del taglio 10, 43126 Parma, Italy.
Quintavalla, Fausto
  • Dipartimento Scienze Medico Veterinarie, Università di Parma, Via del taglio 10, 43126 Parma, Italy.
Ramoni, Roberto
  • Dipartimento Scienze Medico Veterinarie, Università di Parma, Via del taglio 10, 43126 Parma, Italy. roberto.ramoni@unipr.it.

Grant Funding

  • Ramoni - Ric. dipartimentale 2014-70% / Dipartimento di Scienze Medico-Veterinarie, Università di Parma

Conflict of Interest Statement

The authors declare no conflict of interest.

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Citations

This article has been cited 1 times.
  1. Tonelli A, Mangia V, Candiani A, Pasquali F, Mangiaracina TJ, Grazioli A, Sozzi M, Gorni D, Bussolati S, Cucinotta A, Basini G, Selleri S. Sensing Optimum in the Raw: Leveraging the Raw-Data Imaging Capabilities of Raspberry Pi for Diagnostics Applications. Sensors (Basel) 2021 May 20;21(10).
    doi: 10.3390/s21103552pubmed: 34065190google scholar: lookup
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