Clinical insights: Clinicopathological parameters for diagnosing and predicting outcome of horses with colic.
Abstract: No abstract available
Publication Date: 2022-08-31 PubMed ID: 36044554DOI: 10.1111/evj.13871Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Editorial
- Comment
- Clinical Examination
- Clinical Findings
- Clinical Pathology
- Clinical Signs
- Colic
- Diagnosis
- Disease control
- Disease Diagnosis
- Disease Etiology
- Disease Management
- Disease Outbreaks
- Disease Prevention
- Disease Surveillance
- Disease Transmission
- Disease Treatment
- Equine Health
- Horses
- Veterinary Care
- Veterinary Medicine
- Veterinary Practice
- Veterinary Research
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research details the value and approach in using clinicopathological parameters for diagnosing and predicting outcomes in horses suffering from colic. It emphasizes the utility of tests on bodily fluids in determining when surgical intervention is required and offering information about prognosis and survival chances.
Significance of Early Diagnosis and Differentiation of Colic
- Horses with colic can have a better prognosis if the disease is diagnosed early and appropriate treatment is started quickly.
- The study emphasizes the importance of differentiating between strangulating and non-strangulating obstructive lesions, as the treatment varies significantly between these two.
Role of Clinicopathological Parameters
- Traditional diagnosis methods, like history-taking and physical examination, are subjective and can vary based on the observer. Clinicopathological parameters, using samples of bodily fluids such as blood, peritoneal fluid, saliva, or urine, provide objective, uniform data.
- These parameters can often be determined rapidly and inexpensively, making them ideal for situations where time is of the essence.
Utility of Clinicopathological Testing
- These tests help to differentiate between inflammatory and other medical causes of colic from strangulating lesions, potentially enabling quicker and more accurate treatment decisions.
- They also provide vital prognostic information, giving doctors and horse owners an idea of what to expect regarding the horse’s condition and chance of survival.
Benefits for Owners and Veterinarians
- Colic in horses is a condition that can be emotionally and financially straining for the owners. Having reliable, objective test results can guide owners in making appropriate decisions about their horse’s treatment.
- From the perspective of veterinarians or clinicians, these diagnostic and prognostic tests contribute significantly to improving the management of equine colic cases and potentially improving outcomes.
Cite This Article
APA
Long A.
(2022).
Clinical insights: Clinicopathological parameters for diagnosing and predicting outcome of horses with colic.
Equine Vet J, 54(6), 1005-1010.
https://doi.org/10.1111/evj.13871 Publication
Researcher Affiliations
- Department of Clinical Studies, New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square, Pennsylvania, USA.
MeSH Terms
- Animals
- Colic / diagnosis
- Colic / veterinary
- Horse Diseases / diagnosis
- Horse Diseases / pathology
- Horses
References
This article includes 46 references
- Van Den Boom R, Butler CM, Sloet van Oldruitenborgh-Oosterbaan MM. The usability of peritoneal lactate concentration as a prognostic marker in horses with severe colic admitted to a veterinary teaching hospital. Equine Vet Educ 2010;22(8):420-5.
- Latson KM, Nieto JE, Beldomenico PM, Snyder JR. Evaluation of peritoneal fluid lactate as a marker of intestinal ischaemia in equine colic. Equine Vet J 2005;37(4):342-6.
- Johnston K, Holcombe SJ, Hauptman JG. Plasma lactate as a predictor of colonic viability and survival after 360° volvulus of the ascending colon in horses. Vet Surg 2007;36(6):563-7.
- Cullen TE, Curtis L, England GCW, Burford JH, Freeman SL. Systematic review of evidence for plasma and peritoneal lactate as a diagnostic test for surgical colic. Equine Vet J 2015;47(S48):5-6.
- Orr KE, Baker WT, Lynch TM, Hughes FE, Clark CK, Slone DE Jr. Prognostic value of colonic and peripheral venous lactate measurements in horses with large colon volvulus. Vet Surg 2020;49(3):472-9.
- Kawcak CE, Baxter GM, Getzy DM, Stashak TS, Chapman PL. Abnormalities in oxygenation, coagulation, and fibrinolysis in colonic blood of horses with experimentally induced strangulation obstruction. Am J Vet Res 1995;56(12):1642-50.
- Suthers JM, Pinchbeck GL, Proudman CJ, Archer DC. Survival of horses following strangulating large colon volvulus. Equine Vet J 2013;45(2):219-23.
- Radcliffe RM, Divers TJ, Fletcher DJ, Mohammed H, Kraus MS. Evaluation of l-lactate and cardiac troponin I in horses undergoing emergency abdominal surgery. J Vet Emerg Crit Care 2012;22(3):313-9.
- Kos VK, Kramaric P, Brloznik M. Packed cell volume and heart rate to predict medical and surgical cases and their short-term survival in horses with gastrointestinal-induced colic. Can Vet J 2022;63(4):365-72.
- Tennent-Brown BS, Wilkins PA, Lindborg S, Russell G, Boston RC. Sequential plasma lactate concentrations as prognostic indicators in adult equine emergencies. J Vet Intern Med 2010;24(1):198-205.
- Hashimoto-Hill S, Magdesian KG, Kass PH. Serial measurement of lactate concentration in horses with acute colitis. J Vet Intern Med 2011;25(6):1414-9.
- Shearer TR, Norby B, Carr EA. Peritoneal fluid lactate evaluation in horses with nonstrangulating versus strangulating small intestinal disease. J Equine Vet Sci 2018;61:18-21.
- Johnston JK, Morris DD. Comparison of duodenitis/proximal jejunitis and small intestinal obstruction in horses: 68 cases (1977-1985). J Am Vet Med Assoc 1987;191(7):849-54.
- Matthews S, Dart A, Reid S, Dowling B, Hodgson D. Predictive values, sensitivity and specificity of abdominal fluid variables in determining the need for surgery in horses with an acute abdominal crisis. Aust Vet J 2002;80(3):132-6.
- Nieto JE, Aldridge BM, Beldomenico PM, Aleman M, Snyder JR. Characterization of equine intestinal fatty acid binding protein and its use in managing horses with colic. Am J Vet Res 2005;66(2):223-32.
- Krueger CR, Ruple-Czerniak A, Hackett ES. Evaluation of plasma muscle enzyme activity as an indicator of lesion characteristics and prognosis in horses undergoing celiotomy for acute gastrointestinal pain. BMC Vet Res 2014;10(1):S7.
- Kilcoyne I, Nieto JE, Dechant JE. Predictive value of plasma and peritoneal creatine kinase in horses with strangulating intestinal lesions. Vet Surg 2019;48(2):152-8.
- Rodríguez-Pozo ML, Armengou L, Viu J, Ríos J, Jose-Cunilleras E. Peritoneal bile acids concentration in adult horses with hepatic and gastrointestinal disorders. Equine Vet J 2022;54(5):914-21.
- Westerman TL, Foster CM, Tornquist SJ, Poulsen KP. Evaluation of serum amyloid A and haptoglobin concentrations as prognostic indicators for horses with colic. J Am Vet Med Assoc 2016;248(8):935-40.
- Bauquier JR, Forbes G, Nath L, Tudor E, Bailey SR. Plasma HMGB-1 and nucleosome concentrations in horses with colic and healthy horses. J Vet Intern Med 2016;30(1):260-8.
- Pihl TH, Scheepers E, Sanz M, Goddard A, Page P, Toft N. Influence of disease process and duration on acute phase proteins in serum and peritoneal fluid of horses with colic. J Vet Intern Med 2015;29(2):651-8.
- Pihl TH, Scheepers E, Sanz M, Goddard A, Page P, Toft N. Acute-phase proteins as diagnostic markers in horses with colic. J Vet Emerg Crit Care 2016;26(5):664-74.
- Argüelles D, Delgado MA, Armengou L, Carmona JU, Prades M. Relationship between plasma and peritoneal fluid concentrations of D-dimer and transforming growth factor beta 1 in horses with colic. J Equine Vet Sci 2015;35(8):629-35.
- Dondi F, Lukacs RM, Gentilini F, Rinnovati R, Spadari A, Romagnoli N. Serum amyloid A, haptoglobin, and ferritin in horses with colic: association with common clinicopathological variables and short-term outcome. Vet J 2015;205(1):50-5.
- Lopes MAF, Salter CE, Vandenplas ML, Berghaus R, Hurley DJ, Moore JN. Expression of inflammation-associated genes in circulating leukocytes collected from horses with gastrointestinal tract disease. Am J Vet Res 2010;71(8):915-24.
- Bardell D, Milner PI, Goljanek-Whysall K, Peffers MJ. Differences in plasma and peritoneal fluid proteomes identifies potential biomarkers associated with survival following strangulating small intestinal disease. Equine Vet J 2019;51(6):727-32.
- Souto PC, da Fonseca LA, Orozco AMO, Lopez CJR, Ermita PAN, Filho WPC. Acute-phase proteins of healthy horses and horses naturally affected by colic syndrome. J Equine Vet Sci 2019;80:1-4.
- Aitken MR, Stefanovski D, Southwood LL. Serum amyloid A concentration in postoperative colic horses and its association with postoperative complications. Vet Surg 2019;48(2):143-51.
- Cosse C, Sabbagh C, Kamel S, Galmiche A, Regimbeau JM. Procalcitonin and intestinal ischemia: a review of the literature. World J Gastroenterol 2014;20(47):17773-8.
- Kilcoyne I, Nieto JE, Dechant JE. Diagnostic value of plasma and peritoneal fluid procalcitonin concentrations in horses with strangulating intestinal lesions. J Am Vet Med Assoc 2020;256(8):927-33.
- Bonelli F, Meucci V, Divers TJ, Jose-Cunilleras E, Corazza M, Tognetti R. Plasma procalcitonin concentration in healthy horses and horses affected by systemic inflammatory response syndrome. J Vet Intern Med 2015;29(6):1689-91.
- Bonelli F, Meucci V, Divers T, Radcliffe R, Jose-Cunilleras E, Corazza M. Evaluation of plasma procalcitonin concentrations in healthy foals and foals affected by septic systemic inflammatory response syndrome. J Equine Vet Sci 2015;35(8):645-9.
- Bonelli F, Meucci V, Divers TJ, Wagner B, Intorre L, Sgorbini M. Kinetics of plasma procalcitonin, soluble CD14, CCL2 and IL-10 after a sublethal infusion of lipopolysaccharide in horses. Vet Immunol Immunopathol 2017;184:29-35.
- Barton A, Ahrens T, Merle R, Gehlen H. Evaluation of procalcitonin (PCT), neutrophilic gelatinase-associated lipocalin (NGAL), interleukins 1β and 6 as biomarkers for sepsis and endotoxemia in equine colic. Tierärztl Prax Ausg K Kleintiere Heimtiere 2022;50:149.
- Winther MF, Haugaard SL, Pihl TH, Jacobsen S. Concentrations of neutrophil gelatinase-associated lipocalin are elevated in serum and peritoneal fluid from horses with inflammatory abdominal disease and nonstrangulating intestinal infarctions. Equine Vet J 2022.
- Novak F, Vavrova L, Kodydkova J, Novak F Sr, Hynkova M, Zak A. Decreased paraoxonase activity in critically ill patients with sepsis. Clin Exp Med 2010;10(1):21-5.
- Kumon Y, Nakauchi Y, Kidawara K, Fukushima M, Kobayashi S, Ikeda Y. A longitudinal analysis of alteration in lecithin-cholesterol acyltransferase and paraoxonase activities following laparoscopic cholecystectomy relative to other parameters of HDL function and the acute phase response. Scand J Immunol 1998;48(4):419-24.
- Shunmoogam N, Naidoo P, Chilton R. Paraoxonase (PON)-1: a brief overview on genetics, structure, polymorphisms and clinical relevance. Vasc Health Risk Manag 2018;14:137-43.
- Ruggerone B, Paltrinieri S, Giordano A, Scavone D, Nocera I, Rinnovati R. Paraoxonase-1 activity evaluation as a diagnostic and prognostic marker in horses and foals. J Vet Intern Med 2020;34(2):949-54.
- Ruggerone B, Bonelli F, Nocera I, Paltrinieri S, Giordano A, Sgorbini M. Validation of a paraoxon-based method for measurement of paraoxonase (PON-1) activity and establishment of RIs in horses. Vet Clin Pathol 2018;47(1):69-77.
- Nocera I, Bonelli F, Meucci V, Rinnnovati R, Spadari A, Intorre L. Evaluation of protein carbonyl content in healthy and sick hospitalized horses. Front Vet Sci 2020;7:582886.
- Barton AK, Richter IG, Ahrens T, Merle R, Alalwani A, Lilge S. MMP-9 concentration in peritoneal fluid is a valuable biomarker associated with endotoxemia in equine colic. Mediators Inflamm 2021;2021:e9501478.
- Contreras-Aguilar MD, Rubio CP, González-Arostegui LG, Martín-Cuervo M, Cerón JJ, Ayala I. Changes in oxidative status biomarkers in saliva and serum in the equine gastric ulcer syndrome and colic of intestinal aetiology: a pilot study. Animals 2022;12(5):667.
- Contreras-Aguilar MD, Martínez-Subiela S, Cerón JJ, Martín-Cuervo M, Tecles F, Escribano D. Salivary alpha-amylase activity and concentration in horses with acute abdominal disease: association with outcome. Equine Vet J 2019;51(5):569-74.
- Bayless RL, Cooper BL, Sheats MK. Investigation of plasma cell-free DNA as a potential biomarker in horses. J Vet Diagn Invest 2022;34(3):402-6.
- Martín-Cuervo M, Aguirre CN, Gracia LA, Barrera R, Ezquerra LJ, Martinez-Subiela S. Usefulness of a point-of-care analyzer to measure cardiac troponin I and D-dimer concentrations in critically ill horses with gastrointestinal diseases. J Equine Vet Sci 2020;90:102965.
Citations
This article has been cited 1 times.- Ludwig EK, Hobbs KJ, McKinney-Aguirre CA, Gonzalez LM. Biomarkers of Intestinal Injury in Colic. Animals (Basel) 2023 Jan 7;13(2).
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists