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Veterinary microbiology1997; 56(3-4); 313-334; doi: 10.1016/s0378-1135(97)00099-0

Clinical manifestations, diagnosis, treatment, and prevention of Rhodococcus equi infections in foals.

Abstract: Since the 1986 Rhodococcus equi workshop, there have been major breakthroughs in understanding the epidemiology of, the virulence of, and the immune response to, this intriguing pathogen. However, with the exception of the use of hyperimmune plasma for the prevention of the disease (Martens et al., 1989; Madigan et al., 1991) the clinical aspects of R. equi infections have essentially remained unchanged. This article reviews the various clinical manifestations and summarizes recent advances in diagnosis, treatment and prevention of R. equi infections in foals.
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Publication Date: 1997-06-16 PubMed ID: 9226845DOI: 10.1016/s0378-1135(97)00099-0Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article reviews the clinical impacts, methodologies of diagnosis, treatment options, and preventive measures for Rhodococcus equi infections in foals. The paper presents an updated understanding of the disease since a key 1986 workshop, noting that the only major change in clinical aspect since then is the use of hyperimmune plasma for prevention.

Epidemiology of Rhodococcus equi infections

  • The article first reviews the epidemiology of R. equi, a pathogen occurring especially in young horses or foals. There could be mention of how the bacteria spreads, likely prevalence or incidence rates, risk factors for transmission, and specific challenges in foal populations.

Virulence of the Pathogen

  • The next focus is on the virulence of R. equi, which could be explained by examining how damaging the pathogen can be in infecting its host. This review should provide crucial insights into the pathogen’s mechanisms for invading and causing harm to the host’s body, and why it is particularly aggressive or resistant in a foal’s immune system.

Immune Response to the Pathogen

  • The authors also discuss the body’s immune response to R. equi. This would involve investigating how the infected foal’s immune system responds to the attack, including the typical pace and effectiveness of the immune response. It should highlight how the body attempts to fight off the infection and potentially, why this process sometimes fails or is insufficient.

Use of Hyperimmune Plasma in Prevention

  • The study distinctly acknowledges the role of hyperimmune plasma in preventing R. equi infections. Foals may receive hyperimmune plasma from a vaccinated mare, which could contain a high concentration of antibodies against the bacteria. By transfusing this plasma, the foal’s immune system may be better equipped to combat the disease.

Review of Recent Advances in Clinical Aspects

  • The investigators then summarize the latest advancements in the diagnosis, treatment, and prevention of Rhodococcus equi infections. This could encompass anything from the development of more accurate diagnostic tests and the emergence of new therapeutic strategies, to novel prevention programs aimed at minimizing the disease’s incidence in foal populations.

Cite This Article

APA
Giguère S, Prescott JF. (1997). Clinical manifestations, diagnosis, treatment, and prevention of Rhodococcus equi infections in foals. Vet Microbiol, 56(3-4), 313-334. https://doi.org/10.1016/s0378-1135(97)00099-0

Publication

Veterinary microbiology
ISSN: 0378-1135
NlmUniqueID: 7705469
Country: Netherlands
Language: English
Volume: 56
Issue: 3-4
Pages: 313-334

Researcher Affiliations

Giguère, S
  • Department of Pathobiology, Ontario Veterinary College, University of Guelph, Canada. sgiguere@ovcnet.uoguelph.ca
Prescott, J F

    MeSH Terms

    • Actinomycetales Infections / diagnosis
    • Actinomycetales Infections / prevention & control
    • Actinomycetales Infections / therapy
    • Actinomycetales Infections / veterinary
    • Animals
    • Anti-Bacterial Agents / therapeutic use
    • Bronchopneumonia / physiopathology
    • Bronchopneumonia / veterinary
    • Diagnosis, Differential
    • Horse Diseases
    • Horses
    • Pneumonia, Bacterial / physiopathology
    • Pneumonia, Bacterial / veterinary
    • Rhodococcus equi

    Citations

    This article has been cited 45 times.
    1. de Almeida Campos AC, Cicolo S, de Oliveira CM, Molina CV, Navas-Suárez PE, Poltronieri Dos Santos T, da Silveira VB, Barbosa CM, Baccarin RYA, Durigon EL, Góes LGB, Belli CB, Oliveira DBL. Potential outbreak by herpesvirus in equines: detection, clinical, and genetic analysis of equid gammaherpesvirus 2 (EHV-2). Braz J Microbiol 2023 Jun;54(2):1137-1143.
      doi: 10.1007/s42770-022-00890-3pubmed: 36705807google scholar: lookup
    2. Sting R, Schwabe I, Kieferle M, Münch M, Rau J. Fatal Infection in an Alpaca (Vicugna pacos) Caused by Pathogenic Rhodococcus equi. Animals (Basel) 2022 May 19;12(10).
      doi: 10.3390/ani12101303pubmed: 35625149google scholar: lookup
    3. Patterson Rosa L, Mallicote MF, MacKay RJ, Brooks SA. Ion Channel and Ubiquitin Differential Expression during Erythromycin-Induced Anhidrosis in Foals. Animals (Basel) 2021 Nov 25;11(12).
      doi: 10.3390/ani11123379pubmed: 34944156google scholar: lookup
    4. Cohen ND, Kahn SK, Cywes-Bentley C, Ramirez-Cortez S, Schuckert AE, Vinacur M, Bordin AI, Pier GB. Serum Antibody Activity against Poly-N-Acetyl Glucosamine (PNAG), but Not PNAG Vaccination Status, Is Associated with Protecting Newborn Foals against Intrabronchial Infection with Rhodococcus equi. Microbiol Spectr 2021 Sep 3;9(1):e0063821.
      doi: 10.1128/Spectrum.00638-21pubmed: 34319137google scholar: lookup
    5. Rakowska A, Cywinska A, Witkowski L. Current Trends in Understanding and Managing Equine Rhodococcosis. Animals (Basel) 2020 Oct 18;10(10).
      doi: 10.3390/ani10101910pubmed: 33081047google scholar: lookup
    6. Aslam MW, Lau SF, Chin CSL, Ahmad NI, Rahman NA, Kuppusamy K, Omar S, Radzi R. Clinicopathological and radiographic features in 40 cats diagnosed with pulmonary and cutaneous Rhodococcus equi infection (2012-2018). J Feline Med Surg 2020 Aug;22(8):774-790.
      doi: 10.1177/1098612X19886395pubmed: 32400257google scholar: lookup
    7. Bujold AR, Lani NR, Sanz MG. Strain-to-strain variation of Rhodococcus equi growth and biofilm formation in vitro. BMC Res Notes 2019 Aug 19;12(1):519.
      doi: 10.1186/s13104-019-4560-1pubmed: 31426832google scholar: lookup
    8. de Morais ABC, Bolaños CAD, Alves AC, Ikuta CY, Lara GHB, Heinemann MB, Giuffrida R, Listoni FP, de Souza Ribeiro Mioni M, Motta RG, Takai S, Ribeiro MG. Identification of Mycobacterium species and Rhodococcus equi in peccary lymph nodes. Trop Anim Health Prod 2018 Aug;50(6):1319-1326.
      doi: 10.1007/s11250-018-1562-2pubmed: 29546549google scholar: lookup
    9. Tirosh-Levy S, Gürbilek SE, Tel OY, Keskin O, Steinman A. Seroprevalence of Rhodococcus equi in horses in Israel. J S Afr Vet Assoc 2017 Jun 26;88(0):e1-e6.
      doi: 10.4102/jsava.v88i0.1508pubmed: 28697612google scholar: lookup
    10. Trevisani MM, Hanna ES, Oliveira AF, Cardoso SA, Roque-Barreira MC, Soares SG. Vaccination of Mice with Virulence-Associated Protein G (VapG) Antigen Confers Partial Protection against Rhodococcus equi Infection through Induced Humoral Immunity. Front Microbiol 2017;8:857.
      doi: 10.3389/fmicb.2017.00857pubmed: 28553279google scholar: lookup
    11. de Alegría Puig CR, Pilares L, Marco F, Vila J, Martínez-Martínez L, Navas J. Comparison of the Vitek MS and Bruker Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry Systems for Identification of Rhodococcus equi and Dietzia spp. J Clin Microbiol 2017 Jul;55(7):2255-2260.
      doi: 10.1128/JCM.00377-17pubmed: 28490491google scholar: lookup
    12. Willingham-Lane JM, Berghaus LJ, Giguère S, Hondalus MK. Influence of Plasmid Type on the Replication of Rhodococcus equi in Host Macrophages. mSphere 2016 Sep-Oct;1(5).
      doi: 10.1128/mSphere.00186-16pubmed: 27747295google scholar: lookup
    13. Kalinowski M, Grądzki Z, Jarosz Ł, Kato K, Hieda Y, Kakuda T, Takai S. Plasmid Profiles of Virulent Rhodococcus equi Strains Isolated from Infected Foals in Poland. PLoS One 2016;11(4):e0152887.
      doi: 10.1371/journal.pone.0152887pubmed: 27074033google scholar: lookup
    14. Rocha JN, Cohen ND, Bordin AI, Brake CN, Giguère S, Coleman MC, Alaniz RC, Lawhon SD, Mwangi W, Pillai SD. Oral Administration of Electron-Beam Inactivated Rhodococcus equi Failed to Protect Foals against Intrabronchial Infection with Live, Virulent R. equi. PLoS One 2016;11(2):e0148111.
      doi: 10.1371/journal.pone.0148111pubmed: 26828865google scholar: lookup
    15. Krewer Cda C, Spricigo DA, de Avila Botton S, da Costa MM, Schrank I, de Vargas AC. Molecular characterization of Rhodococcus equi Isolates of horse breeding farms from an endemic region in South of Brazil by multiplex PCR. Braz J Microbiol 2008 Jan;39(1):188-93.
      doi: 10.1590/S1517-838220080001000036pubmed: 24031201google scholar: lookup
    16. Schlusselhuber M, Jung S, Bruhn O, Goux D, Leippe M, Leclercq R, Laugier C, Grötzinger J, Cauchard J. In vitro potential of equine DEFA1 and eCATH1 as alternative antimicrobial drugs in rhodococcosis treatment. Antimicrob Agents Chemother 2012 Apr;56(4):1749-55.
      doi: 10.1128/AAC.05797-11pubmed: 22232283google scholar: lookup
    17. Hsu FF, Wohlmann J, Turk J, Haas A. Structural definition of trehalose 6-monomycolates and trehalose 6,6'-dimycolates from the pathogen Rhodococcus equi by multiple-stage linear ion-trap mass spectrometry with electrospray ionization. J Am Soc Mass Spectrom 2011 Dec;22(12):2160-70.
      doi: 10.1007/s13361-011-0240-7pubmed: 21972013google scholar: lookup
    18. van der Geize R, Grommen AW, Hessels GI, Jacobs AA, Dijkhuizen L. The steroid catabolic pathway of the intracellular pathogen Rhodococcus equi is important for pathogenesis and a target for vaccine development. PLoS Pathog 2011 Aug;7(8):e1002181.
      doi: 10.1371/journal.ppat.1002181pubmed: 21901092google scholar: lookup
    19. Guerrero R, Bhargava A, Nahleh Z. Rhodococcus equi venous catheter infection: a case report and review of the literature. J Med Case Rep 2011 Aug 9;5:358.
      doi: 10.1186/1752-1947-5-358pubmed: 21827681google scholar: lookup
    20. Kuskie KR, Smith JL, Wang N, Carter CN, Chaffin MK, Slovis NM, Stepusin RS, Cattoi AE, Takai S, Cohen ND. Effects of location for collection of air samples on a farm and time of day of sample collection on airborne concentrations of virulent Rhodococcus equi at two horse breeding farms. Am J Vet Res 2011 Jan;72(1):73-9.
      doi: 10.2460/ajvr.72.1.73pubmed: 21194338google scholar: lookup
    21. Hsu FF, Soehl K, Turk J, Haas A. Characterization of mycolic acids from the pathogen Rhodococcus equi by tandem mass spectrometry with electrospray ionization. Anal Biochem 2011 Feb 1;409(1):112-22.
      doi: 10.1016/j.ab.2010.10.006pubmed: 20946862google scholar: lookup
    22. Niwa H, Lasker BA. Mutant selection window and characterization of allelic diversity for ciprofloxacin-resistant mutants of Rhodococcus equi. Antimicrob Agents Chemother 2010 Aug;54(8):3520-3.
      doi: 10.1128/AAC.01670-09pubmed: 20498313google scholar: lookup
    23. Oliveira AF, Ruas LP, Cardoso SA, Soares SG, Roque-Barreira MC. Vaccination of mice with salmonella expressing VapA: mucosal and systemic Th1 responses provide protection against Rhodococcus equi infection. PLoS One 2010 Jan 13;5(1):e8644.
      doi: 10.1371/journal.pone.0008644pubmed: 20072623google scholar: lookup
    24. Muscatello G, Gilkerson JR, Browning GF. Detection of virulent Rhodococcus equi in exhaled air samples from naturally infected foals. J Clin Microbiol 2009 Mar;47(3):734-7.
      doi: 10.1128/JCM.01395-08pubmed: 19144811google scholar: lookup
    25. Flaminio MJ, Nydam DV, Marquis H, Matychak MB, Giguère S. Foal monocyte-derived dendritic cells become activated upon Rhodococcus equi infection. Clin Vaccine Immunol 2009 Feb;16(2):176-83.
      doi: 10.1128/CVI.00336-08pubmed: 19109450google scholar: lookup
    26. Muscatello G, Anderson GA, Gilkerson JR, Browning GF. Associations between the ecology of virulent Rhodococcus equi and the epidemiology of R. equi pneumonia on Australian thoroughbred farms. Appl Environ Microbiol 2006 Sep;72(9):6152-60.
      doi: 10.1128/AEM.00495-06pubmed: 16957241google scholar: lookup
    27. Rodríguez-Lázaro D, Lewis DA, Ocampo-Sosa AA, Fogarty U, Makrai L, Navas J, Scortti M, Hernández M, Vázquez-Boland JA. Internally controlled real-time PCR method for quantitative species-specific detection and vapA genotyping of Rhodococcus equi. Appl Environ Microbiol 2006 Jun;72(6):4256-63.
      doi: 10.1128/AEM.02706-05pubmed: 16751540google scholar: lookup
    28. Ladrón N, Fernández M, Agüero J, González Zörn B, Vázquez-Boland JA, Navas J. Rapid identification of Rhodococcus equi by a PCR assay targeting the choE gene. J Clin Microbiol 2003 Jul;41(7):3241-5.
      doi: 10.1128/JCM.41.7.3241-3245.2003pubmed: 12843070google scholar: lookup
    29. Riess FG, Elflein M, Benk M, Schiffler B, Benz R, Garton N, Sutcliffe I. The cell wall of the pathogenic bacterium Rhodococcus equi contains two channel-forming proteins with different properties. J Bacteriol 2003 May;185(9):2952-60.
      doi: 10.1128/JB.185.9.2952-2960.2003pubmed: 12700275google scholar: lookup
    30. Ashour J, Hondalus MK. Phenotypic mutants of the intracellular actinomycete Rhodococcus equi created by in vivo Himar1 transposon mutagenesis. J Bacteriol 2003 Apr;185(8):2644-52.
      doi: 10.1128/JB.185.8.2644-2652.2003pubmed: 12670990google scholar: lookup
    31. Giguère S, Hernandez J, Gaskin J, Prescott JF, Takai S, Miller C. Performance of five serological assays for diagnosis of Rhodococcus equi pneumonia in foals. Clin Diagn Lab Immunol 2003 Mar;10(2):241-5.
      doi: 10.1128/cdli.10.2.241-245.2003pubmed: 12626449google scholar: lookup
    32. Vengust M, Staempfli H, Prescott JF. Rhodococcus equi pleuropneumonia in an adult horse. Can Vet J 2002 Sep;43(9):706-8.
      pubmed: 12240529
    33. Benoit S, Benachour A, Taouji S, Auffray Y, Hartke A. H(2)O(2), which causes macrophage-related stress, triggers induction of expression of virulence-associated plasmid determinants in Rhodococcus equi. Infect Immun 2002 Jul;70(7):3768-76.
      doi: 10.1128/IAI.70.7.3768-3776.2002pubmed: 12065520google scholar: lookup
    34. Patel A. Pyogranulomatous skin disease and cellulitis in a cat caused by Rhodococcus equi. J Small Anim Pract 2002 Mar;43(3):129-32.
      doi: 10.1111/j.1748-5827.2002.tb00043.xpubmed: 11916057google scholar: lookup
    35. Navas J, González-Zorn B, Ladrón N, Garrido P, Vázquez-Boland JA. Identification and mutagenesis by allelic exchange of choE, encoding a cholesterol oxidase from the intracellular pathogen Rhodococcus equi. J Bacteriol 2001 Aug;183(16):4796-805.
      doi: 10.1128/JB.183.16.4796-4805.2001pubmed: 11466283google scholar: lookup
    36. Sellon DC, Besser TE, Vivrette SL, McConnico RS. Comparison of nucleic acid amplification, serology, and microbiologic culture for diagnosis of Rhodococcus equi pneumonia in foals. J Clin Microbiol 2001 Apr;39(4):1289-93.
      doi: 10.1128/JCM.39.4.1289-1293.2001pubmed: 11283043google scholar: lookup
    37. Darrah PA, Hondalus MK, Chen Q, Ischiropoulos H, Mosser DM. Cooperation between reactive oxygen and nitrogen intermediates in killing of Rhodococcus equi by activated macrophages. Infect Immun 2000 Jun;68(6):3587-93.
      doi: 10.1128/IAI.68.6.3587-3593.2000pubmed: 10816516google scholar: lookup
    38. Bowersock TL, Salmon SA, Portis ES, Prescott JF, Robison DA, Ford CW, Watts JL. MICs of oxazolidinones for Rhodococcus equi strains isolated from humans and animals. Antimicrob Agents Chemother 2000 May;44(5):1367-9.
      doi: 10.1128/AAC.44.5.1367-1369.2000pubmed: 10770781google scholar: lookup
    39. Giguère S, Hondalus MK, Yager JA, Darrah P, Mosser DM, Prescott JF. Role of the 85-kilobase plasmid and plasmid-encoded virulence-associated protein A in intracellular survival and virulence of Rhodococcus equi. Infect Immun 1999 Jul;67(7):3548-57.
      doi: 10.1128/IAI.67.7.3548-3557.1999pubmed: 10377138google scholar: lookup
    40. Boneva-Marutsova B, Marutsov P, Kerner K, Zhelev G. First Detection of Rhodococcus equi in a Foal in Bulgaria-A Case Report. Animals (Basel) 2025 Jul 12;15(14).
      doi: 10.3390/ani15142058pubmed: 40723521google scholar: lookup
    41. Golen GS, Erganiş O, Balevi A. Comparison of the efficacies of Rhodococcus equi recombinant vaccine in mice. Vet Res Forum 2025;16(5):253-259.
      doi: 10.30466/vrf.2024.2028438.4266pubmed: 40693028google scholar: lookup
    42. Santos INS, Lilenbaum W, Moreno DSA, Bastos MDCF. Production of bacteriocin-like inhibitory substance (BLIS) by Staphylococcus spp. isolates from dogs. Braz J Microbiol 2024 Dec;55(4):3885-3897.
      doi: 10.1007/s42770-024-01532-6pubmed: 39467939google scholar: lookup
    43. Alvarez Narvaez S, Sanchez S. Exploring the Accessory Genome of Multidrug-Resistant Rhodococcus equi Clone 2287. Antibiotics (Basel) 2023 Nov 17;12(11).
      doi: 10.3390/antibiotics12111631pubmed: 37998833google scholar: lookup
    44. Guardabassi L, Apley M, Olsen JE, Toutain PL, Weese S. Optimization of Antimicrobial Treatment to Minimize Resistance Selection. Microbiol Spectr 2018 May;6(3).
      doi: 10.1128/microbiolspec.ARBA-0018-2017pubmed: 29932044google scholar: lookup
    45. Passamonti F, Lepri E, Coppola G, Sforna M, Casagrande Proietti P, Chiodetti I, Coletti M, Marenzoni ML. Pulmonary rhodococcosis in a cat. J Feline Med Surg 2011 Apr;13(4):283-5.
      doi: 10.1016/j.jfms.2010.12.003pubmed: 21273105google scholar: lookup
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