Clinical trial of moxidectin oral gel in horses.
Abstract: A clinical trial carried out over 98 days was done to evaluate treatment of horses with moxidectin gel for efficacy as measured by (1) reduction in the production of parasite ova post treatment, (2) a comparison of the posttreatment parasite egg count suppression of moxidectin to ivermectin, and (3) assessment of the field safety, animal acceptance of the moxidectin formulation, and the utility of the moxidectin delivery device. One hundred and fifty Standardbred horses with naturally acquired parasite infections were used in the study. Moxidectin had more prolonged and greater suppressive influence than did ivermectin on reappearance and magnitude of strongyle egg counts post treatment. Differences were not observed between the capability of ivermectin or moxidectin to reduce and suppress low Parascaris equorum egg counts. Adverse reactions to treatments were not observed, and the utility of the moxidectin delivery syringe and animal acceptance of moxidectin treatment were satisfactory.
Publication Date: 1997-12-24 PubMed ID: 9404843DOI: 10.1016/s0304-4017(97)01108-4Google Scholar: Lookup
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- Clinical Trial
- Comparative Study
- Controlled Clinical Trial
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This study conducted a 98-day trial on 150 Standardbred horses to assess the effectiveness and safety of treating equine parasite infections with moxidectin gel. The results indicated that moxidectin had a better and lasting suppressive effect than ivermectin on some parasites, without causing adverse reactions in the horses.
Overview of the Trial
- The trial was carried out over a period of 98 days and used 150 Standardbred horses that naturally acquired parasite infections as the subjects of the test.
- The study was specifically designed to evaluate the efficacy of moxidectin gel in treating these infections, in comparison to a commonly used anti-parasitic drug called ivermectin.
- The efficacy of the treatment was measured by the extent to which it reduced the production of parasite eggs post-treatment, and how it suppressed post-treatment parasite egg counts in comparison to ivermectin.
Results of the Trial
- The results of the trial showed that moxidectin had a significantly more prolonged and greater suppressive effect on the reappearance and magnitude of strongyle (a type of horse worm) egg counts post treatment compared to ivermectin.
- However, for low Parascaris equorum (a type of roundworm in horses) egg counts, there were no observed differences between the capabilities of ivermectin or moxidectin to reduce and suppress these counts.
- No adverse reactions to either treatment were observed during the trial, suggesting that moxidectin gel is safe for use in horses.
Utility and Acceptance
- Apart from the efficacy and safety, the study also sought to assess the utility of the moxidectin delivery device, which was in the form of a syringe, and the animal acceptance of the moxidectin treatment.
- Both the utility of the delivery syringe and animal acceptance of the moxidectin treatment were found to be satisfactory by the researchers.
Cite This Article
APA
DiPietro JA, Hutchens DE, Lock TF, Walker K, Paul AJ, Shipley C, Rulli D.
(1997).
Clinical trial of moxidectin oral gel in horses.
Vet Parasitol, 72(2), 167-177.
https://doi.org/10.1016/s0304-4017(97)01108-4 Publication
Researcher Affiliations
- Department of Veterinary Pathobiology, College of Veterinary Medicine, Gainesville, FL 32610-0125, USA.
MeSH Terms
- Administration, Oral
- Animals
- Anthelmintics / therapeutic use
- Anti-Bacterial Agents
- Gels
- Horse Diseases
- Horses
- Ivermectin / administration & dosage
- Ivermectin / therapeutic use
- Macrolides / administration & dosage
- Macrolides / therapeutic use
- Parasite Egg Count / veterinary
- Strongylida Infections / drug therapy
- Strongylida Infections / veterinary
- Strongylus
Citations
This article has been cited 5 times.- Macdonald SL, Abbas G, Ghafar A, Gauci CG, Bauquier J, El-Hage C, Tennent-Brown B, Wilkes EJA, Beasley A, Jacobson C, Cudmore L, Carrigan P, Hurley J, Beveridge I, Hughes KJ, Nielsen MK, Jabbar A. Egg reappearance periods of anthelmintics against equine cyathostomins: The state of play revisited.. Int J Parasitol Drugs Drug Resist 2023 Apr;21:28-39.
- Johnson ACB, Biddle AS. The Use of Molecular Profiling to Track Equine Reinfection Rates of Cyathostomin Species Following Anthelmintic Administration.. Animals (Basel) 2021 May 9;11(5).
- Nielsen MK, Banahan M, Kaplan RM. Importation of macrocyclic lactone resistant cyathostomins on a US thoroughbred farm.. Int J Parasitol Drugs Drug Resist 2020 Dec;14:99-104.
- Scare JA, Leathwick DM, Sauermann CW, Lyons ET, Steuer AE, Jones BA, Clark M, Nielsen MK. Dealing with double trouble: Combination deworming against double-drug resistant cyathostomins.. Int J Parasitol Drugs Drug Resist 2020 Apr;12:28-34.
- Elsener J, Villeneuve A. Comparative long-term efficacy of ivermectin and moxidectin over winter in Canadian horses treated at removal from pastures for winter housing.. Can Vet J 2009 May;50(5):486-90.
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