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The Journal of antimicrobial chemotherapy2014; 69(10); 2676-2680; doi: 10.1093/jac/dku217

Clonal spread of highly successful ST15-CTX-M-15 Klebsiella pneumoniae in companion animals and horses.

Abstract: To investigate the clinical relevance and molecular epidemiology of extended-spectrum β-lactamase (ESBL)-producing Klebsiella species in animals. Methods: Antimicrobial susceptibilities and presence of ESBLs were examined among Klebsiella spp. (n = 1519) from clinical samples (>1200 senders from Germany and other European countries) mainly from companion animals and horses from October 2008 to March 2010. Multilocus sequence typing (MLST) and PFGE were performed including human isolates for comparative purposes. Results: The overall ESBL rate was 8% for Klebsiella pneumoniae subsp. pneumoniae. Most K. pneumoniae subsp. pneumoniae ESBL producers were isolated from soft tissue infections (29.3%) and urinary tract infections (14.9%). The major ESBL type was CTX-M-15 (85.4%), located on different plasmid scaffolds (HI2, I1, FIA, FIB, FII, A/C, R and N). Other ESBL genes, such as bla(CTX-M-1) (5.6%), bla(CTX-M-3), bla(CTX-M-9), bla(SHV-2) and bla(SHV-12) (1.1% each), were also detected. Additional resistances, e.g. to fluoroquinolones (89.9%), were frequently present. ST15-CTX-M-15, a clonal group that recently emerged in humans, accounted for 75.8% of the strains analysed by MLST and there was evidence for nosocomial events in five veterinary clinics. Human ST15-CTX-M-15 strains shared PFGE clusters with animal isolates, suggesting the dissemination of this clonal group between both populations. Conclusions: Our data indicate a wide spread of ST15-CTX-M-15 K. pneumoniae subsp. pneumoniae, which should be considered as a zoonotic agent of high clinical relevance for humans and animals. Further research should be undertaken to unravel both microevolutionary and biological aspects probably contributing to this global success.
© The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
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Publication Date: 2014-06-27 PubMed ID: 24974381DOI: 10.1093/jac/dku217Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study investigates the clinical importance and molecular characteristics of the extended-spectrum β-lactamase (ESBL)-producing Klebsiella species in animals, with a focus on ESBL-producing Klebsiella pneumoniae. The research highlights the spread of a specific clonal group, ST15-CTX-M-15, in both humans and animals, suggesting it as a potentially significant zoonotic agent.

Research Objectives and Methods

  • The purpose of this study was to understand the clinical significance and molecular epidemiology of ESBL-producing Klebsiella species in animals, primarily pets and horses.
  • Klebsiella samples were collected and tested for antimicrobial susceptibilities and presence of ESBLs.
  • Methods involved multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE), including testing isolates from humans for comparison.

Findings and Results

  • The overall ESBL rate was 8% for Klebsiella pneumoniae. Most of the time, these ESBL-producing bacteria were found in soft tissue infections and urinary tract infections.
  • The predominant ESBL type was CTX-M-15, found in 85.4% of the cases. This type was located on various plasmid scaffolds. Other ESBL genes were also detected, though at much lower rates.
  • In addition to ESBL, the Klebsiella pneumoniae showed resistance to other antibiotics, such as fluoroquinolones, in a significant majority of cases (89.9%).
  • ST15-CTX-M-15, a clonal group that recently emerged in humans, accounted for 75.8% of the strains analyzed. Clusters of human ST15-CTX-M-15 shared similarities with animal isolates, suggesting a possible cross-transmission between humans and animals.

Conclusion and Implications

  • The research concludes that the wide spread of ST15-CTX-M-15 K. pneumoniae is a critical concern both in human and veterinary medicine. It suggests that this strain is a zoonotic agent, meaning it can pass between animals and humans.
  • The dissemination of the ST15-CTX-M-15 clonal group calls for further research to understand the microevolutionary and biological aspects that contribute to its success. This research could lead to better control and prevention strategies for ESBL-producing Klebsiella infections across both human and animal health.

Cite This Article

APA
Ewers C, Stamm I, Pfeifer Y, Wieler LH, Kopp PA, Schønning K, Prenger-Berninghoff E, Scheufen S, Stolle I, Günther S, Bethe A. (2014). Clonal spread of highly successful ST15-CTX-M-15 Klebsiella pneumoniae in companion animals and horses. J Antimicrob Chemother, 69(10), 2676-2680. https://doi.org/10.1093/jac/dku217

Publication

The Journal of antimicrobial chemotherapy
ISSN: 1460-2091
NlmUniqueID: 7513617
Country: England
Language: English
Volume: 69
Issue: 10
Pages: 2676-2680

Researcher Affiliations

Ewers, Christa
  • Institute of Hygiene and Infectious Diseases of Animals, Justus-Liebig-Universität Giessen, Giessen, Germany christa.ewers@vetmed.uni-giessen.de.
Stamm, Ivonne
  • Vet Med Labor GmbH, Division of IDEXX Laboratories, Ludwigsburg, Germany.
Pfeifer, Yvonne
  • Robert Koch Institute, FG13 Nosocomial Pathogens and Antibiotic Resistance, Wernigerode, Germany.
Wieler, Lothar H
  • Institute of Microbiology and Epizootics, Centre for Infection Medicine, Freie Universität Berlin, Berlin, Germany.
Kopp, Peter A
  • Vet Med Labor GmbH, Division of IDEXX Laboratories, Ludwigsburg, Germany.
Schønning, K
  • Department of Clinical Microbiology 445, Hvidovre Hospital, Hvidovre, Denmark Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Prenger-Berninghoff, Ellen
  • Institute of Hygiene and Infectious Diseases of Animals, Justus-Liebig-Universität Giessen, Giessen, Germany.
Scheufen, Sandra
  • Institute of Hygiene and Infectious Diseases of Animals, Justus-Liebig-Universität Giessen, Giessen, Germany.
Stolle, Inka
  • Institute of Hygiene and Infectious Diseases of Animals, Justus-Liebig-Universität Giessen, Giessen, Germany.
Günther, Sebastian
  • Institute of Microbiology and Epizootics, Centre for Infection Medicine, Freie Universität Berlin, Berlin, Germany.
Bethe, Astrid
  • Institute of Microbiology and Epizootics, Centre for Infection Medicine, Freie Universität Berlin, Berlin, Germany.

MeSH Terms

  • Animal Diseases / microbiology
  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Conjugation, Genetic
  • Genotype
  • Horse Diseases / microbiology
  • Horses
  • Klebsiella Infections / veterinary
  • Klebsiella pneumoniae / classification
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / genetics
  • Microbial Sensitivity Tests
  • Multilocus Sequence Typing
  • Phenotype
  • Phylogeny
  • beta-Lactam Resistance / genetics
  • beta-Lactamases / genetics

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