Combined active-passive immunisation of horses against tetanus.
Abstract: The protection afforded by active, passive and combined active-passive methods of immunisation against tetanus was examined in previously unimmunised horses. Three groups of horses were injected; one with tetanus toxoid alone, one with tetanus antitoxin alone and one in which the tetanus toxoid and tetanus antitoxin were injected simultaneously. The protection afforded was determined by monitoring the levels of antitoxin achieved in the horses by each of these methods. The results obtained demonstrated the effectiveness of the combined active-passive method in affording rapid and prolonged protection and enabled the examination of some of the factors involved in active and in passive immunisation when used alone. The advantages obtained by the use of the combined active-passive method in protecting unimmunised horses suddenly placed at risk to infection are outlined.
Publication Date: 1980-03-01 PubMed ID: 7436904DOI: 10.1111/j.1751-0813.1980.tb05647.xGoogle Scholar: Lookup
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- Comparative Study
- Journal Article
Summary
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This research examines the effectiveness of different methods of immunization against tetanus in horses. The study found that a combined active-passive immunization approach provided rapid and prolonged protection against the infection.
Experiment Overview
- The study was conducted on horses that had not been previously immunised against tetanus.
- Three distinct groups were formed among the horses, each exposed to a different method of immunisation.
- The different methods used include active immunisation (using tetanus toxoid), passive immunisation (using tetanus antitoxin), and a combination of both.
Immunisation Methods
- Active immunisation involved injecting the horses with tetanus toxoid. This primes the immune system to recognise and combat tetanus infections in the future.
- Passive immunisation utilised tetanus antitoxin, providing immediate short-term protection by offering antibodies to counter the infection.
- In the combined active-passive immunisation, both the tetanus toxoid and antitoxin were administered simultaneously.
Analysis
- The effectiveness of each immunisation method was gauged by tracking the levels of antitoxin in each horse.
- The result of the study demonstrated that the combined active-passive method offered rapid and prolonged protection against tetanus.
- This combined method also allowed an examination of the different factors involved in active and passive immunisation when used separately.
Implications
- The research delineates the benefits of using a combined active-passive immunisation strategy, particularly for non-immunised horses suddenly at risk of tetanus infection.
- While more research may be necessary for further validation, this study contributes significantly to understanding the best immunization methods for horses against tetanus.
Cite This Article
APA
Liefman CE.
(1980).
Combined active-passive immunisation of horses against tetanus.
Aust Vet J, 56(3), 119-122.
https://doi.org/10.1111/j.1751-0813.1980.tb05647.x Publication
Researcher Affiliations
MeSH Terms
- Animals
- Female
- Horse Diseases / prevention & control
- Horses
- Immunization / veterinary
- Injections, Subcutaneous
- Male
- Tetanus / prevention & control
- Tetanus / veterinary
- Tetanus Antitoxin / administration & dosage
- Tetanus Antitoxin / analysis
- Tetanus Toxoid / administration & dosage
Citations
This article has been cited 1 times.- Desanti-Consoli H, Bouillon J, Chapuis RJJ. Equids' Core Vaccines Guidelines in North America: Considerations and Prospective. Vaccines (Basel) 2022 Mar 4;10(3).
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