Comparative rheumatology: what can be learnt from naturally occurring musculoskeletal disorders in domestic animals?
Abstract: Examples of naturally occurring musculoskeletal disorders are extremely common in veterinary species and provide a valuable comparative research resource, which can provide compelling comparative data on the aetiopathogenesis and treatment of many common human musculoskeletal diseases. In particular, orthopaedic diseases are a common morbidity in both dogs and horses. In this review, we give an overview of the common musculoskeletal diseases encountered in these species: for instance, tendon and ligament injuries, arthropathies and stress fractures, as well as an insight into the basic biology of these conditions. In doing so, we aim to demonstrate the similarities and differences between these disorders and similar conditions in man.
Publication Date: 2010-02-21 PubMed ID: 20176567DOI: 10.1093/rheumatology/kep465Google Scholar: Lookup
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- Journal Article
- Review
Summary
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The research article discusses the learnings that can be drawn from naturally occurring musculoskeletal disorders in domestic animals for human musculoskeletal diseases.
Overview of the common musculoskeletal diseases in animals
- The paper explores common musculoskeletal disorders found in veterinary species particularly dogs and horses. These include tendon and ligament injuries, arthropathies (joint diseases), and stress fractures. The authors outline the basic biology of these conditions, gaining insight into their occurrence, development, and treatment.
Significance of comparative rheumatology
- Comparative rheumatology offers a significant research resource by examining musculoskeletal disorders in domestic animals which are naturally occurring. These instances provide important comparative data on the cause and progression (aetiopathogenesis) and treatment of common human musculoskeletal diseases.
Similarities and Differences in Disorders
- The goal of the paper is not only to shed light on these common diseases in animals but also to identify the similarities and differences between these disorders and their counterparts in humans. By understanding how these diseases manifest in different species, researchers can gain valuable insights which might lead to advancements in the treatment and prevention of these diseases in humans.
Implications of the study
- The findings have broader implications in the field of rheumatology and related branches of medicine. The comparison allows for the transfer of knowledge between veterinary and human medicine, potentially leading to breakthroughs in understanding the nature of these diseases and improvement in their treatment methods.
Cite This Article
APA
Innes JF, Clegg P.
(2010).
Comparative rheumatology: what can be learnt from naturally occurring musculoskeletal disorders in domestic animals?
Rheumatology (Oxford), 49(6), 1030-1039.
https://doi.org/10.1093/rheumatology/kep465 Publication
Researcher Affiliations
- Musculoskeletal Research Group, Department of Comparative Molecular Medicine, School of Veterinary Science, University of Liverpool, Leahurst Campus, Neston, Cheshire CH64 7TE, UK. j.f.innes@liv.ac.uk
MeSH Terms
- Animals
- Animals, Domestic
- Arthritis / genetics
- Arthritis / physiopathology
- Arthritis / veterinary
- Breeding
- Disease Models, Animal
- Dog Diseases / genetics
- Dog Diseases / physiopathology
- Dogs
- Female
- Genetic Predisposition to Disease
- Horse Diseases / genetics
- Horse Diseases / physiopathology
- Horses
- Humans
- Ligaments / injuries
- Male
- Musculoskeletal Diseases / genetics
- Musculoskeletal Diseases / physiopathology
- Musculoskeletal Diseases / veterinary
- Pedigree
- Risk Factors
- Tendon Injuries / physiopathology
Citations
This article has been cited 19 times.- Marr N, Zamboulis DE, Werling D, Felder AA, Dudhia J, Pitsillides AA, Thorpe CT. The tendon interfascicular basement membrane provides a vascular niche for CD146+ cell subpopulations. Front Cell Dev Biol 2022;10:1094124.
- Lee S, Baker ME, Clinton M, Taylor SE. Use of Omics Data in Fracture Prediction; a Scoping and Systematic Review in Horses and Humans. Animals (Basel) 2021 Mar 30;11(4).
- Meeson RL, Perpétuo IP, Parsons K, Orriss IR, Shah M, Pitsillides AA, Doube M. The in vitro behaviour of canine osteoblasts derived from different bone types. BMC Vet Res 2019 Apr 11;15(1):114.
- Donahue SW. Krogh's principle for musculoskeletal physiology and pathology. J Musculoskelet Neuronal Interact 2018 Sep 1;18(3):284-291.
- Baird A, Lindsay T, Everett A, Iyemere V, Paterson YZ, McClellan A, Henson FMD, Guest DJ. Osteoblast differentiation of equine induced pluripotent stem cells. Biol Open 2018 May 10;7(5).
- Godinho MSC, Thorpe CT, Greenwald SE, Screen HRC. Elastin is Localised to the Interfascicular Matrix of Energy Storing Tendons and Becomes Increasingly Disorganised With Ageing. Sci Rep 2017 Aug 30;7(1):9713.
- Thorpe CT, Riley GP, Birch HL, Clegg PD, Screen HRC. Fascicles and the interfascicular matrix show adaptation for fatigue resistance in energy storing tendons. Acta Biomater 2016 Sep 15;42:308-315.
- Thorpe CT, Karunaseelan KJ, Ng Chieng Hin J, Riley GP, Birch HL, Clegg PD, Screen HR. Distribution of proteins within different compartments of tendon varies according to tendon type. J Anat 2016 Sep;229(3):450-8.
- Knazovicky D, Helgeson ES, Case B, Gruen ME, Maixner W, Lascelles BDX. Widespread somatosensory sensitivity in naturally occurring canine model of osteoarthritis. Pain 2016 Jun;157(6):1325-1332.
- Thorpe CT, Peffers MJ, Simpson D, Halliwell E, Screen HR, Clegg PD. Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition. Sci Rep 2016 Feb 4;6:20455.
- Thorpe CT, Godinho MSC, Riley GP, Birch HL, Clegg PD, Screen HRC. The interfascicular matrix enables fascicle sliding and recovery in tendon, and behaves more elastically in energy storing tendons. J Mech Behav Biomed Mater 2015 Dec;52:85-94.
- Peffers MJ, McDermott B, Clegg PD, Riggs CM. Comprehensive protein profiling of synovial fluid in osteoarthritis following protein equalization. Osteoarthritis Cartilage 2015 Jul;23(7):1204-13.
- Knazovicky D, Tomas A, Motsinger-Reif A, Lascelles BD. Initial evaluation of nighttime restlessness in a naturally occurring canine model of osteoarthritis pain. PeerJ 2015;3:e772.
- Peffers MJ, Thorpe CT, Collins JA, Eong R, Wei TK, Screen HR, Clegg PD. Proteomic analysis reveals age-related changes in tendon matrix composition, with age- and injury-specific matrix fragmentation. J Biol Chem 2014 Sep 12;289(37):25867-78.
- Peffers MJ, Cillero-Pastor B, Eijkel GB, Clegg PD, Heeren RM. Matrix assisted laser desorption ionization mass spectrometry imaging identifies markers of ageing and osteoarthritic cartilage. Arthritis Res Ther 2014 May 9;16(3):R110.
- Thorpe CT, Riley GP, Birch HL, Clegg PD, Screen HR. Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loading. J R Soc Interface 2014 Mar 6;11(92):20131058.
- Peffers M, Liu X, Clegg P. Transcriptomic signatures in cartilage ageing. Arthritis Res Ther 2013 Aug 23;15(4):R98.
- Iwasaki N, Llewellyn J, Brown J, Zamboulis DE, Finding EJT, Wheeler-Jones CPD, Thorpe CT. Immunolabelling and Micro-Computed Tomography Revealed Age-Related Alterations in 3D Microvasculature of Tendons. Aging Cell 2026 Jan;25(1):e70293.
- Zamboulis DE, Marr N, Lenzi L, Birch HL, Screen HRC, Clegg PD, Thorpe CT. The Interfascicular Matrix of Energy Storing Tendons Houses Heterogenous Cell Populations Disproportionately Affected by Aging. Aging Dis 2024 Feb 1;15(1):295-310.
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