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Home / Equine Research Bank / Vet Rec / Comparative studies of ivermectin and moxidectin in the cont...
The Veterinary record1997; 141(15); 383-386; doi: 10.1136/vr.141.15.383

Comparative studies of ivermectin and moxidectin in the control of naturally acquired cyathostome infections in horses.

Abstract: The control of naturally acquired cyathostome infections in horses by treatments with ivermectin and moxidectin was evaluated in three field studies. In a first study the efficacy of both drugs was assessed in a faecal egg count reduction test. Both ivermectin and moxidectin demonstrated efficacies greater than 99 per cent for up to 60 days after treatment. In a second study, the period required for strongyle eggs to reappear was estimated in horses treated either with ivermectin or moxidectin. For the horses treated with ivermectin the period varied between 10 and approximately 13 weeks, and for moxidectin between 22 and approximately 24 weeks. With both drugs strongyle eggs started to reappear in the faeces significantly earlier in foals and young horses than in adults. In a third study, two prophylactic dosing schemes involving three ivermectin treatments at intervals of eight weeks, and two moxidectin treatments 12 weeks apart, were found to be highly effective in controlling strongyle infections of horses on pasture.
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Publication Date: 1997-11-19 PubMed ID: 9364706DOI: 10.1136/vr.141.15.383Google Scholar: Lookup
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  • Comparative Study
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study is about comparing Ivermectin and Moxidectin’s efficiency in controlling naturally occurring cyathostome infections in horses, based on three different field studies.

General Overview

  • The research assessed the ability of two drugs, Ivermectin and Moxidectin, in controlling cyathostome infections in horses which occur naturally. Cyathostomes are a variety of parasitic worms that affect horses and could lead to colic or other severe health issues.
  • The analysis was carried out in three distinct field studies, each designed to assess different aspects of the drugs’ efficiency.

Study One – Faecal Egg Count Reduction Test

  • The first examination tested the efficiency of the drugs by conducting a Faecal Egg Count Reduction (FECR) test, which is a common method to evaluate the success of deworming treatments.
  • The findings indicated that both Ivermectin and Moxidectin had efficacies higher than 99% for up to 60 days post-treatment.

Study Two – Estimation of Strongyle Reappearance

  • The second test estimated the time required for strongyle eggs to reappear after a horse had been treated with either Ivermectin or Moxidectin. Strongyles are another type of worm parasites affecting horses.
  • For horses treated with Ivermectin, the eggs started to reappear between 10 and roughly 13 weeks. As for moxidectin, the reappearance span was between 22 weeks and approximately 24 weeks.
  • Significantly, the eggs started to reappear earlier in the faeces of young horses and foals compared to adults, regardless of the treatment they received.

Study Three – Prophylactic Dosing Schemes

  • In the third study, researchers assessed the success of two preventative dosing schemes. One scheme consisted of three Ivermectin treatments at intervals of eight weeks, and the other incorporated two Moxidectin treatments 12 weeks apart.
  • The results showed that both dosing plans were extremely effective in controlling strongyle infections in pasture horses.

Cite This Article

APA
Demeulenaere D, Vercruysse J, Dorny P, Claerebout E. (1997). Comparative studies of ivermectin and moxidectin in the control of naturally acquired cyathostome infections in horses. Vet Rec, 141(15), 383-386. https://doi.org/10.1136/vr.141.15.383

Publication

The Veterinary record
ISSN: 0042-4900
NlmUniqueID: 0031164
Country: England
Language: English
Volume: 141
Issue: 15
Pages: 383-386

Researcher Affiliations

Demeulenaere, D
  • Department of Parasitology, University of Gent, Merelheke, Belgium.
Vercruysse, J
    Dorny, P
      Claerebout, E

        MeSH Terms

        • Animals
        • Anti-Bacterial Agents
        • Antinematodal Agents / therapeutic use
        • Feces / parasitology
        • Female
        • Horses
        • Ivermectin / therapeutic use
        • Macrolides / therapeutic use
        • Male
        • Parasite Egg Count
        • Strongyle Infections, Equine / drug therapy
        • Strongyloidea

        Citations

        This article has been cited 8 times.
        1. Bull KE, Allen KJ, Hodgkinson JE, Peachey LE. The first report of macrocyclic lactone resistant cyathostomins in the UK.. Int J Parasitol Drugs Drug Resist 2023 Apr;21:125-130.
          doi: 10.1016/j.ijpddr.2023.03.001pubmed: 36940551google scholar: lookup
        2. Macdonald SL, Abbas G, Ghafar A, Gauci CG, Bauquier J, El-Hage C, Tennent-Brown B, Wilkes EJA, Beasley A, Jacobson C, Cudmore L, Carrigan P, Hurley J, Beveridge I, Hughes KJ, Nielsen MK, Jabbar A. Egg reappearance periods of anthelmintics against equine cyathostomins: The state of play revisited.. Int J Parasitol Drugs Drug Resist 2023 Apr;21:28-39.
          doi: 10.1016/j.ijpddr.2022.12.002pubmed: 36543048google scholar: lookup
        3. Johnson ACB, Biddle AS. The Use of Molecular Profiling to Track Equine Reinfection Rates of Cyathostomin Species Following Anthelmintic Administration.. Animals (Basel) 2021 May 9;11(5).
          doi: 10.3390/ani11051345pubmed: 34065099google scholar: lookup
        4. Nielsen MK, Banahan M, Kaplan RM. Importation of macrocyclic lactone resistant cyathostomins on a US thoroughbred farm.. Int J Parasitol Drugs Drug Resist 2020 Dec;14:99-104.
          doi: 10.1016/j.ijpddr.2020.09.004pubmed: 33022574google scholar: lookup
        5. Scare JA, Leathwick DM, Sauermann CW, Lyons ET, Steuer AE, Jones BA, Clark M, Nielsen MK. Dealing with double trouble: Combination deworming against double-drug resistant cyathostomins.. Int J Parasitol Drugs Drug Resist 2020 Apr;12:28-34.
          doi: 10.1016/j.ijpddr.2019.12.002pubmed: 31883485google scholar: lookup
        6. Molena RA, Peachey LE, Di Cesare A, Traversa D, Cantacessi C. Cyathostomine egg reappearance period following ivermectin treatment in a cohort of UK Thoroughbreds.. Parasit Vectors 2018 Jan 25;11(1):61.
          doi: 10.1186/s13071-018-2638-6pubmed: 29370872google scholar: lookup
        7. Zak A, Siwinska N, Slowikowska M, Borowicz H, Kubiak K, Hildebrand J, Popiolek M, Niedzwiedz A. Searching for ivermectin resistance in a Strongylidae population of horses stabled in Poland.. BMC Vet Res 2017 Jul 3;13(1):210.
          doi: 10.1186/s12917-017-1133-1pubmed: 28673347google scholar: lookup
        8. Elsener J, Villeneuve A. Comparative long-term efficacy of ivermectin and moxidectin over winter in Canadian horses treated at removal from pastures for winter housing.. Can Vet J 2009 May;50(5):486-90.
          pubmed: 19436633
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