Comparison of magnetic resonance imaging, computed tomography, and radiography for assessment of noncartilaginous changes in equine metacarpophalangeal osteoarthritis.
Abstract: We compared the ability of 1.5 T magnetic resonance imaging (MRI), computed tomography (CT), and computed radiography (CR) to evaluate noncartilaginous structures of the equine metacarpophalangeal joint (MCP), and the association of imaging changes with gross cartilage damage in the context of osteoarthritis. Four CR projections, helical single-slice CT, and MRI (Ti-weighted gradient recalled echo [GRE], T2*-weighted GRE with fast imaging employing steady-state acquisition [FIESTA], T2-weighted fast spin echo with fat saturation, and spoiled gradient recalled echo with fat saturation ISPGR-FS]) were performed on 20 racehorse cadaver forelimbs. Osteophytosis, synovial effusion, subchondral bone lysis and sclerosis, supracondylar lysis, joint fragments, bone marrow lesions, and collateral desmopathy were assessed with each modality. Interexaminer agreement was inferior to intraexaminer agreement and was generally moderate (i.e., 0.4 < kappa < 0.6). Subchondral bone sclerosis scores using CT or MRI were correlated significantly with the reference quantitative CT technique used to assess bone mineral density (P < 0.0001). Scores for subchondral lysis and osteophytosis were higher with MRI or CT vs. CR (P < 0.0001). Although differences between modalities were noted, osteophytosis, subchondral sclerosis, and lysis as well as synovial effusion were all associated with the degree of cartilage damage and should be further evaluated as potential criteria to be included in a whole-organ scoring system. This study highlights the capacity of MRI to evaluate noncartilaginous changes in the osteoarthritic equine MCP joint.
Publication Date: 2010-05-18 PubMed ID: 20469548DOI: 10.1111/j.1740-8261.2009.01653.xGoogle Scholar: Lookup
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- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
- Anatomy
- Bones
- Cadaver
- Clinical Study
- Comparative Study
- Computed Tomography
- Diagnosis
- Diagnostic Imaging
- Disease Diagnosis
- Equine Diseases
- Equine Health
- Horses
- Magnetic Resonance Imaging
- Metacarpophalangeal Joint
- Musculoskeletal System
- Osteoarthritis
- Racehorses
- Radiology
- Subchondral Bone
- Veterinary Care
- Veterinary Medicine
Summary
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This research explores the comparison of the effectiveness of Magnetic Resonance Imaging (MRI), Computed Tomography (CT), and Computed Radiography (CR) in assessing non-cartilaginous changes related to osteoarthritis in a horse’s metacarpophalangeal joint; highlighting that all were associated with the extent of cartilage damage, with MRI proving especially effective.
Research Methodology
- The researchers performed multiple imaging scans on 20 forelimbs collected from deceased racehorses, including CT, CR, and various forms of MRI.
- They examined changes in non-cartilaginous structures, such as cases of osteophytosis (bony growth significance of osteoarthritis), synovial effusion (accumulation of fluid in a joint), subchondral bone sclerosis and lysis (hardening and breakdown, respectively), supracondylar lysis, joint fragments, bone marrow abnormalities, and collateral desmopathy (damage to ligaments).
- After individual analysis, interexaminer and intraexaminer level of agreement were evaluated, with the former found to be moderate.
Results and Conclusion
- The researchers found a significant correlation between the scores of subchondral bone sclerosis (hardening beneath cartilage of joints), ascertained using MRI or CT, and the reference quantitative CT technique utilized to review bone mineral density.
- Scoring higher with MRI or CT compared to CR, it was found that changes such as osteophytosis, subchondral sclerosis, and lysis as well as synovial effusion were all associated to some degree with the severity of the cartilage damage.
- In conclusion, while different modalities indicated different results, osteophytosis, subchondral sclerosis, and lysis, as well as synovial effusion, were identified to be associated with the extent of cartilage damage, suggesting these as potential criteria to be included in a whole-organ scoring system.
- The study underscored the capability of MRI as an effective tool to evaluate non-cartilaginous changes in the osteoarthritic equine metacarpophalangeal joint.
Cite This Article
APA
Olive J, D'Anjou MA, Alexander K, Laverty S, Theoret C.
(2010).
Comparison of magnetic resonance imaging, computed tomography, and radiography for assessment of noncartilaginous changes in equine metacarpophalangeal osteoarthritis.
Vet Radiol Ultrasound, 51(3), 267-279.
https://doi.org/10.1111/j.1740-8261.2009.01653.x Publication
Researcher Affiliations
- Department of Veterinary Biomedicine, Faculté de medecine veterinaire, Université de Montreal, 3200 rue Sicotte, P.O. Box 5000, Saint-Hyacinthe, QC, Canada.
MeSH Terms
- Animals
- Arthrography / veterinary
- Bone and Bones / diagnostic imaging
- Bone and Bones / pathology
- Forelimb
- Horse Diseases / diagnosis
- Horse Diseases / diagnostic imaging
- Horses
- Joints / pathology
- Magnetic Resonance Imaging / veterinary
- Osteoarthritis / diagnosis
- Osteoarthritis / veterinary
- Tomography, X-Ray Computed / veterinary
Citations
This article has been cited 10 times.- Steel C, Ahern B, Zedler S, Vallance S, Galuppo L, Richardson J, Whitton C, Young A. Comparison of Radiography and Computed Tomography for Evaluation of Third Carpal Bone Fractures in Horses.. Animals (Basel) 2023 Apr 25;13(9).
- Johnston GCA, Ahern BJ, Palmieri C, Young AC. Imaging and Gross Pathological Appearance of Changes in the Parasagittal Grooves of Thoroughbred Racehorses.. Animals (Basel) 2021 Nov 24;11(12).
- Bertoni L, Jacquet-Guibon S, Branly T, Desancé M, Legendre F, Melin M, Rivory P, Hartmann DJ, Schmutz A, Denoix JM, Demoor M, Audigié F, Galéra P. Evaluation of Allogeneic Bone-Marrow-Derived and Umbilical Cord Blood-Derived Mesenchymal Stem Cells to Prevent the Development of Osteoarthritis in An Equine Model.. Int J Mol Sci 2021 Mar 2;22(5).
- Johnston GCA, Ahern BJ, Woldeyohannes SM, Young AC. Does the Low-Field MRI Appearance of Intraosseous STIR Hyperintensity in Equine Cadaver Limbs Change when Subjected to a Freeze-Thaw Process?. Animals (Basel) 2021 Feb 11;11(2).
- Bertoni L, Jacquet-Guibon S, Branly T, Legendre F, Desancé M, Mespoulhes C, Melin M, Hartmann DJ, Schmutz A, Denoix JM, Galéra P, Demoor M, Audigié F. An experimentally induced osteoarthritis model in horses performed on both metacarpophalangeal and metatarsophalangeal joints: Technical, clinical, imaging, biochemical, macroscopic and microscopic characterization.. PLoS One 2020;15(6):e0235251.
- Lacitignola L, Imperante A, Staffieri F, De Siena R, De Luca P, Muci A, Crovace A. Assessment of Intra- and Inter-observer Measurement Variability in a Radiographic Metacarpophalangeal Joint Osteophytosis Scoring System for the Horse.. Vet Sci 2020 Apr 6;7(2).
- Braucke AFGV, Frederiksen NL, Berg LC, Aarsvold S, Müller FC, Boesen MP, Lindegaard C. Identification and Quantification of Transient Receptor Potential Vanilloid 1 (TRPV1) in Equine Articular Tissue.. Animals (Basel) 2020 Mar 18;10(3).
- Smith AD, Morton AJ, Winter MD, Colahan PT, Ghivizzani S, Brown MP, Hernandez JA, Nickerson DM. MAGNETIC RESONANCE IMAGING SCORING OF AN EXPERIMENTAL MODEL OF POST-TRAUMATIC OSTEOARTHRITIS IN THE EQUINE CARPUS.. Vet Radiol Ultrasound 2016 Sep;57(5):502-14.
- Boyce MK, Trumble TN, Carlson CS, Groschen DM, Merritt KA, Brown MP. Non-terminal animal model of post-traumatic osteoarthritis induced by acute joint injury.. Osteoarthritis Cartilage 2013 May;21(5):746-55.
- Galindo-Zamora V, Dziallas P, Ludwig DC, Nolte I, Wefstaedt P. Diagnostic accuracy of a short-duration 3 Tesla magnetic resonance protocol for diagnosing stifle joint lesions in dogs with non-traumatic cranial cruciate ligament rupture.. BMC Vet Res 2013 Feb 28;9:40.
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