Comparison of the clearance of 99mTechnetium-DTPA from the lung and lung function indices derived from the single breath diagram for carbon dioxide in horses with chronic obstructive pulmonary disease.
Abstract: The elimination of carbon dioxide from the lung can be used to monitor ventilation and perfusion, and 99mtechnetium-diethylenetriaminepentaacetate (99mTc-DTPA) clearance is a highly sensitive index of alveolar epithelial integrity, which is a presupposition for effective gas exchange. The aim of this study was to determine whether a correlation exists between indices of lung function derived from the single breath diagram for CO2, and 99mTc-DTPA clearance in horses with chronic obstructive pulmonary disease. The rate of 99mTc-DTPA elimination was negatively and substantially correlated with the dead space according to Bohr's formula, and the physiological and alveolar dead space. Strong and significant correlations existed between the three dead space indices and the alveolar fraction of CO2, and the ratio A1/A2 as an index of alveolar efficiency. The associations found were dependent on the clinical status of health and the mode of calculation of 99mTc-DTPA alveolar clearance.
Publication Date: 2002-01-05 PubMed ID: 11765812DOI: 10.1046/j.1439-0442.2001.00384.xGoogle Scholar: Lookup
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- Journal Article
- Chronic Obstructive Pulmonary Disease
- Clinical Findings
- Clinical Study
- Correlation Analysis
- Diagnosis
- Diagnostic Technique
- Disease Diagnosis
- Disease Management
- Disease Treatment
- Equine Diseases
- Equine Health
- Equine Science
- Horses
- Lung Health
- Pathophysiology
- Physiology
- Pulmonary Health
- Respiratory Disease
- Respiratory Health
- Veterinary Medicine
- Veterinary Research
Summary
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The research focuses on comparing the elimination of 99mTechnetium-DTPA from the lungs and the lung function features found in the carbon dioxide diagram in horses suffering from chronic obstructive pulmonary disease. It establishes that there’s a significant correlation between the rate of 99mTc-DTPA clearance and the dead space as per Bohr’s formula. The results were dependent on the health status of the horses and the calculation method used for 99mTc-DTPA alveolar clearance.
Research Aims and Objectives
- The primary objective of this study was to ascertain if there’s a relationship between the indices of lung function derived from carbon dioxide’s single breath diagram and the clearance of 99mtechnetium-diethylenetriaminepentaacetate (99mTc-DTPA) in horses suffering from chronic obstructive pulmonary disease (COPD).
Study Methods
- The researchers studied the rate of 99mTc-DTPA clearance, a substance known to be a sensitive index of alveolar epithelial integrity which in turn is necessary for effective gas exchange.
- This elimination of 99mTc-DTPA was compared against known indicators of lung function in horses with COPD.
Study Findings
- The research found that there is a strong and negative correlation between the 99mTc-DTPA clearance rate and the dead space as per Bohr’s equation, including the physiological and alveolar dead space.
- Significant correlations were also established between the three dead space indices and the CO2 alveolar fraction, as well as the A1/A2 ratio as an index of alveolar efficiency.
- The researchers observed that the associations discovered were highly dependent on the horses’ health and the variation in the calculation procedure of 99mTc-DTPA alveolar clearance.
Conclusions and Implications
- The findings from this study imply that monitoring the 99mTc-DTPA clearance could provide a useful indication of lung function indices in horses with COPD.
- By pointing to a correlation between 99mTc-DTPA clearance and indices derived from the CO2 single breath diagram, this study suggests that the two could potentially be used simultaneously to provide a more comprehensive view of lung function in horses with COPD.
Cite This Article
APA
Herholz C, Phillip M, Straub R, Ueltschi G, Busato A.
(2002).
Comparison of the clearance of 99mTechnetium-DTPA from the lung and lung function indices derived from the single breath diagram for carbon dioxide in horses with chronic obstructive pulmonary disease.
J Vet Med A Physiol Pathol Clin Med, 48(9), 553-561.
https://doi.org/10.1046/j.1439-0442.2001.00384.x Publication
Researcher Affiliations
- Department of Equine Internal Medicine, Berne, Switzerland. herholz@knp.unibe.ch
MeSH Terms
- Animals
- Carbon Dioxide
- Female
- Horse Diseases / diagnosis
- Horse Diseases / physiopathology
- Horses
- Kinetics
- Lung / metabolism
- Male
- Pulmonary Disease, Chronic Obstructive / diagnosis
- Pulmonary Disease, Chronic Obstructive / physiopathology
- Pulmonary Disease, Chronic Obstructive / veterinary
- Radiopharmaceuticals / pharmacokinetics
- Respiratory Function Tests / veterinary
- Technetium Tc 99m Pentetate / pharmacokinetics
Citations
This article has been cited 1 times.- Mazan MR, Lascola K, Bruns SJ, Hoffman AM. Use of a novel one-nostril mask-spacer device to evaluate airway hyperresponsiveness (AHR) in horses after chronic administration of albuterol. Can J Vet Res 2014 Jul;78(3):214-20.
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