Comparison of the effects of topical application of UMF20 and UMF5 manuka honey with a generic multifloral honey on wound healing variables in an uncontaminated surgical equine distal limb wound model.
Abstract: To compare the effect of application of manuka honey with unique manuka factor (UMF) 5 or 20 with a generic multifloral honey on equine wound healing variables. Methods: Two full-thickness skin wounds (2.5 × 2.5 cm) were created on the metatarsus of both hindlimbs of eight Standardbred horses. The wounds on each horse were assigned to 1 of 4 treatments: UMF20 (UMF20) and UMF5 (UMF5) manuka honey; generic multifloral honey (GH); and a saline control. Bandages were changed daily for 12 days, after which treatment was stopped and the bandages were removed. Wound area was measured on day 1, then weekly until day 42. Overall wound healing rate (cm2 /day) and time to complete healing were recorded. Results: There was no difference in wound area for any of the treatments on any measurement day except for day 21, where the mean wound area for wounds treated with UMF20 was smaller than the mean wound area for the UMF5-treated wounds (P = 0.031). There was no difference in mean (± SE) overall healing rate (cm2 /day) among the treatment groups. There were differences in mean (± SE) days to complete healing. Wounds treated with UMF20 healed faster than wounds treated with GH (P = 0.02) and control wounds (P = 0.01). Conclusions: Treatment of wounds with UMF20 reduced overall wound healing time compared with wounds treated with GH and control wounds. However, using this model the difference in the overall time to complete healing was small.
© 2017 Australian Veterinary Association.
Publication Date: 2017-07-17 PubMed ID: 28714567DOI: 10.1111/avj.12616Google Scholar: Lookup
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- Comparative Study
- Journal Article
Summary
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This research evaluated the effectiveness of different types of Manuka honey – categorized by Unique Manuka Factor (UMF) 5 and UMF 20 – in comparison to generic multifloral honey, for the treatment and healing of wounds on horses’ legs. The study found that there was not a significant difference in the wound healing speed among the honey types, except at day 21, where UMF 20 honey-treated wounds showed smaller areas than UMF 5. UMF 20 honey-treated wounds healed faster compared to those treated with general honey and a control (saline).
Methodology
- The study was conducted on eight Standardbred horses. Two full-thickness skin wounds of 2.5 x 2.5 cm were artificially created on the metatarsus of both hindlimbs.
- The wounds were divided into four treatment categories: UMF20 and UMF5 manuka honey, generic multifloral honey, and a saline solution.
- The treatment involved daily bandage change for 12 days. Afterwards, the treatment was ceased and the bandages were taken off.
- The wound area was gauged on day 1, and then every week up until day 42. The elements noted were overall speed of wound healing (cm/day) and the total time taken for complete healing.
Results
- The study found no significant differences in wound areas across the treatment groups for any measurement day with the exception of day 21.
- On day 21, the UMF20-treated wounds were smaller on average compared to UMF5-treated wounds.
- No significant differences were identified among the treatment groups in terms of overall average healing rate (cm/day).
- Differences were noted in the average total days taken to completely heal. Wounds treated with UMF20 healed faster than those treated with generic honey and the control.
Conclusions
- UMF20 application on the wounds seemingly reduced the overall time taken for wound healing in comparison to wounds treated with generic honey and the saline control.
- However, the difference in the overall time taken for complete healing was negligible in this model of treatment.
Cite This Article
APA
Tsang AS, Dart AJ, Sole-Guitart A, Dart CM, Perkins NR, Jeffcott LB.
(2017).
Comparison of the effects of topical application of UMF20 and UMF5 manuka honey with a generic multifloral honey on wound healing variables in an uncontaminated surgical equine distal limb wound model.
Aust Vet J, 95(9), 333-337.
https://doi.org/10.1111/avj.12616 Publication
Researcher Affiliations
- Research and Clinical Trials Unit, University Veterinary Teaching Hospital Camden, University of Sydney, 410 Werombi Road, Camden, New South Wales 2570, Australia.
- Research and Clinical Trials Unit, University Veterinary Teaching Hospital Camden, University of Sydney, 410 Werombi Road, Camden, New South Wales 2570, Australia.
- Research and Clinical Trials Unit, University Veterinary Teaching Hospital Camden, University of Sydney, 410 Werombi Road, Camden, New South Wales 2570, Australia.
- Research and Clinical Trials Unit, University Veterinary Teaching Hospital Camden, University of Sydney, 410 Werombi Road, Camden, New South Wales 2570, Australia.
- School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia.
- Research and Clinical Trials Unit, University Veterinary Teaching Hospital Camden, University of Sydney, 410 Werombi Road, Camden, New South Wales 2570, Australia.
MeSH Terms
- Animals
- Bandages
- Honey
- Horses / injuries
- Wound Healing / drug effects
- Wound Healing / physiology
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