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Home / Equine Research Bank / Vet Med Sci / Concurrent thoracic mesothelioma and thyroid C-cell adenoma ...
Veterinary medicine and science2017; 4(1); 63-70; doi: 10.1002/vms3.87

Concurrent thoracic mesothelioma and thyroid C-cell adenoma with amyloid deposition in an aged horse.

Abstract: A 21-year-old American Saddlebred mare died with a history of weight loss and breathing difficulties of 1 month duration. Post-mortem examination revealed a copious pleural effusion with multifocal to coalescing numerous white to grey nodular masses on the serosal surface of the pericardium, lungs and thoracic cavity. In addition, the left thyroid gland was markedly enlarged. A thoracic mesothelioma and C-cell adenoma with amyloid deposits of the left thyroid gland were diagnosed by histopathology and confirmed by immunohistochemistry employing antibodies against cytokeratin (CK), vimentin and calcitonin. Amyloid deposits in the thyroid tumour were confirmed by Congo red staining with apple-green birefringence under polarized light. Mesothelioma remains an uncommon neoplasm encountered in aged horses. Discussion includes the diagnostic challenge of differentiating carcinomatosis from mesothelioma by histology and differentiating reactive and neoplastic mesothelial cells by cytology.
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Publication Date: 2017-12-14 PubMed ID: 29468082PubMed Central: PMC5813108DOI: 10.1002/vms3.87Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article is about a case study of a mare that had both a lung cancer type called thoracic mesothelioma and a thyroid C-cell adenoma with a certain kind of protein deposit. The diagnosis was confirmed through microscopic examination of tissues and chemical staining techniques.

Case Overview

  • The study involves a 21-year-old mare that was suffering from weight loss and respiratory difficulties.
  • Post-mortem examination revealed abnormal masses on various internal surfaces, including the pleural effusion (fluid around the lungs), the pericardium (outer covering of the heart), and the left thyroid gland.
  • The ailments that were connected to these masses were identified as thoracic mesothelioma and a C-cell adenoma with amyloid deposits in the left thyroid gland.

Diagnostic Techniques

  • The researchers confirmed these diagnoses through histopathology, a study which involves the microscopic examination of biological tissues to observe the appearance of diseased cells and tissues in very fine detail.
  • Immunohistochemistry was another technique employed in this case, which involves the process of selectively imaging antigens (proteins) in cells of a tissue section by exploiting the principle of antibodies binding specifically to antigens in biological tissues.
  • The researchers used antibodies against cytokeratin (CK), vimentin and calcitonin to help identify the diseases.
  • The titan protein deposit, is called an amyloid deposit, and was confirmed with Congo red staining, which when observed under polarized light, exhibited an apple-green birefringence – a characteristic feature of amyloid deposits.

Discussion and Challenges

  • Being an uncommon in aged horses, mesothelioma presents a unique diagnostic challenge.
  • The study discusses the difficulty in differentiating mesothelioma from carcinomatosis (widespread cancer in the body) by histology, due to their similar histological appearance.
  • It also highlights the challenges in differentiating between reactive (non-harmful, regular physiological response) and neoplastic (abnormal, often harmful) mesothelial cells using cytology (the study of cells).

Cite This Article

APA
Fortin JS, Royal AB, Kuroki K. (2017). Concurrent thoracic mesothelioma and thyroid C-cell adenoma with amyloid deposition in an aged horse. Vet Med Sci, 4(1), 63-70. https://doi.org/10.1002/vms3.87

Publication

Veterinary medicine and science
ISSN: 2053-1095
NlmUniqueID: 101678837
Country: England
Language: English
Volume: 4
Issue: 1
Pages: 63-70

Researcher Affiliations

Fortin, Jessica S
  • Veterinary Medical Diagnostic LaboratoryUniversity of MissouriColumbiaMissouriUSA.
Royal, Angela B
  • Veterinary Medical Diagnostic LaboratoryUniversity of MissouriColumbiaMissouriUSA.
Kuroki, Keiichi
  • Veterinary Medical Diagnostic LaboratoryUniversity of MissouriColumbiaMissouriUSA.

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Citations

This article has been cited 1 times.
  1. Passantino G, Sassi E, Filippi I, Serata V, Tinelli A, Zizzo N. Thoracic and Abdominal Mesothelioma in an Older Horse in Lazio Region.. Animals (Basel) 2022 Sep 25;12(19).
    doi: 10.3390/ani12192560pubmed: 36230301google scholar: lookup
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