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Home / Equine Research Bank / J Virol / Course and extent of variation of equine infectious anemia v...
Journal of virology1987; 61(4); 1266-1270; doi: 10.1128/JVI.61.4.1266-1270.1987

Course and extent of variation of equine infectious anemia virus during parallel persistent infections.

Abstract: Comparisons of peptide and oligonucleotide maps of glycoproteins and RNA from nine isolates of equine infectious anemia virus (EIAV) that were generated during parallel infections of two Shetland ponies revealed that each isolate was structurally unique. Each EIAV isolate contained a unique subset of variant peptides, oligonucleotides, or both, indicating that structural variation in EIAV is a random and noncumulative process and that a large spectrum of possible EIAV variants can be generated in infected animals.
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Publication Date: 1987-04-01 PubMed ID: 3029423PubMed Central: PMC254092DOI: 10.1128/JVI.61.4.1266-1270.1987Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't
  • Research Support
  • U.S. Gov't
  • P.H.S.

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article examines how the equine infectious anemia virus (EIAV) varies in structure during different, simultaneous infections in two Shetland ponies.

Research Objective

  • The purpose of this research was to investigate how the Equine Infectious Anemia Virus (EIAV) evolves in structure during parallel infections. To understand this, researchers took samples from nine different EIAV cases.

Methodology

  • The team analyzed samples using peptide and oligonucleotide maps. Peptides (chains of amino acids) and oligonucleotides (short sequences of nucleotides) were compared through mapping to identify evolutionary changes in the virus structure.
  • These samples were drawn from two Shetland ponies. The two subjects provided a controlled environment for the investigation, enabling researchers to observe structural changes in similar situations.

Findings

  • The research found that each of the analysed EIAV samples was structurally unique. This structural difference was seen at the level of distinct variants of peptides and oligonucleotides present in each isolate.
  • The findings suggest that the structural variation in EIAV is random and noncumulative. This indicates that the changes seen in the virus do not build upon previous versions and each variation is unique and independent.
  • This observation further alludes to the possibility that a wide variety of EIAV variants can be produced in infected animals.

Implications

  • The results from this study contribute to the overall understanding of the equine infectious anemia virus. The discovery that each virus isolate is structurally unique could have implications for the development of treatments or vaccines. This could potentially mean that a single treatment or vaccine may not be effective for all variants of the virus.
  • The noncumulative nature of the virus and the potential for a large number of variants may pose challenges in combating the disease and prevent a straightforward solution.

Cite This Article

APA
Payne SL, Salinovich O, Nauman SM, Issel CJ, Montelaro RC. (1987). Course and extent of variation of equine infectious anemia virus during parallel persistent infections. J Virol, 61(4), 1266-1270. https://doi.org/10.1128/JVI.61.4.1266-1270.1987

Publication

Journal of virology
ISSN: 0022-538X
NlmUniqueID: 0113724
Country: United States
Language: English
Volume: 61
Issue: 4
Pages: 1266-1270

Researcher Affiliations

Payne, S L
    Salinovich, O
      Nauman, S M
        Issel, C J
          Montelaro, R C

            MeSH Terms

            • Animals
            • Equine Infectious Anemia / microbiology
            • Genetic Variation
            • Horses
            • Infectious Anemia Virus, Equine / genetics
            • Peptide Fragments / analysis
            • Trypsin
            • Viral Envelope Proteins / genetics
            • Viral Envelope Proteins / isolation & purification

            Grant Funding

            • CA-38851 / NCI NIH HHS

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