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Equine veterinary journal2011; 44(3); 297-303; doi: 10.1111/j.2042-3306.2011.00440.x

Cross-sectional study of antimicrobial-resistant bacteria in horses. Part 2: Risk factors for faecal carriage of antimicrobial-resistant Escherichia coli in horses.

Abstract: The increasing prevalence of antimicrobial resistant bacteria such as antimicrobial-resistant and extended spectrum β-lactamase (ESBL)-producing Escherichia coli represents a significant problem for human and veterinary medicine. Despite this, the risk factors for faecal carriage of such bacteria by horses in the UK, particularly those in the wider community, have not been well described. Objective: To characterise the risk factors for faecal carriage of antimicrobial-resistant E. coli amongst horses in the mainland UK. Methods: A cross-sectional study of horses recruited by 65 randomly selected equine veterinary practices was conducted, with a faecal sample collected and self-administered questionnaire completed by the horse owner. Faecal samples were cultured for antimicrobial-resistant E. coli, with isolates confirmed as E. coli having their antimicrobial resistance profile determined. Multilevel, multivariable logistic regression models were used to investigate risk factors for the carriage of antimicrobial-resistant E. coli in the sample population. Results: Faecal samples and completed questionnaires were obtained for 627 horses located on 475 premises. Recent hospitalisation, contact with specific types of nonequid animals, the type of premises, the surrounding land use, the reason for veterinary treatment received in the last 6 months and antimicrobial treatment in the previous 10 days were identified as risk factors for many of the antimicrobial-resistance outcomes considered. Being stabled on the same yard as a recently hospitalised horse was identified as a risk factor for increased risk of carriage of ESBL-producing E. coli. Conclusions: Increasing antimicrobial resistance may have significant health implications for the horse population of Great Britain. This form of epidemiological investigation highlights potential risk factors that may be controlled to limit the extent of the problem.
© 2011 EVJ Ltd.
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Publication Date: 2011-08-18 PubMed ID: 21848536DOI: 10.1111/j.2042-3306.2011.00440.xGoogle Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study examined the risk factors associated with the presence of antimicrobial-resistant E. coli in horse feces in the UK. The researchers collected samples from horses across various locations, identifying several risk factors, including recent hospital visits and contact with certain animals, which can contribute to the carriage of these resistant bacteria.

Methodology

  • The researchers conducted a cross-sectional study which involved collecting fecal samples from horses.
  • The sampling population for the study was obtained from 65 randomly chosen equine veterinary practices.
  • Horse owners were also asked to complete a self-administered questionnaire.
  • The fecal samples were cultured for antimicrobial-resistant E. coli, and the bacterial isolates were confirmed as E. coli. Their antimicrobial resistance profile was later determined.
  • Using multilevel, multivariable logistic regression models, the researchers evaluated different risk factors for the carriage of antimicrobial-resistant E. coli within the sampled population.

Findings

  • Fecal samples and questionnaires were collected from 627 horses across 475 different premises.
  • The study identified several risk factors that increase the likelihood of horses carrying these resistant bacteria. These included recent hospitalization, interaction with certain non-equine animals, the nature of the premises and surrounding land use, and the reason for recent veterinary treatments.
  • Antimicrobial treatment received by the horses within the last 10 days also emerged as a significant risk factor.
  • The study also found that horses stabled in the same yard as a recently hospitalized horse were at an increased risk of carrying ESBL-producing E. coli.

Implications

  • The study suggests that the rise in antimicrobial resistance might pose serious health issues for the horse population in Great Britain.
  • This epidemiological investigation helps identify potential controllable risk factors to limit the spread of antimicrobial-resistant bacteria among horses.

Cite This Article

APA
Maddox TW, Pinchbeck GL, Clegg PD, Wedley AL, Dawson S, Williams NJ. (2011). Cross-sectional study of antimicrobial-resistant bacteria in horses. Part 2: Risk factors for faecal carriage of antimicrobial-resistant Escherichia coli in horses. Equine Vet J, 44(3), 297-303. https://doi.org/10.1111/j.2042-3306.2011.00440.x

Publication

Equine veterinary journal
ISSN: 2042-3306
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 44
Issue: 3
Pages: 297-303

Researcher Affiliations

Maddox, T W
  • National Centre for Zoonosis Research, School of Veterinary Sciences, University of Liverpool, UK. thomas.maddox@liverpool.ac.uk
Pinchbeck, G L
    Clegg, P D
      Wedley, A L
        Dawson, S
          Williams, N J

            MeSH Terms

            • Animal Husbandry
            • Animals
            • Anti-Bacterial Agents / pharmacology
            • Carrier State / epidemiology
            • Carrier State / microbiology
            • Carrier State / veterinary
            • Cross-Sectional Studies
            • Data Collection
            • Drug Resistance, Multiple, Bacterial
            • Escherichia coli Infections / epidemiology
            • Escherichia coli Infections / microbiology
            • Escherichia coli Infections / veterinary
            • Feces / microbiology
            • Female
            • Horse Diseases / epidemiology
            • Horse Diseases / microbiology
            • Horses
            • Housing, Animal
            • Male
            • Risk Factors
            • Surveys and Questionnaires
            • United Kingdom / epidemiology

            Citations

            This article has been cited 14 times.
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