Cross-species and intraspecies morphometric analysis of the corpus callosum.
Abstract: A cross-species morphometric study of the corpus callosum was performed in the rat, rabbit, cat, dog, horse, cow and human. Across species, the results indicate a strong, although less than linear, dependency of callosal size on brain weight. This relation tends to lose significance within species. This is consistent with other morphometric studies indicating a tendency to decrease the correlations between morphometric variables in within-species analyses as compared to between-species analyses. There are species differences in the relative size of some callosal segments particularly in the posterior third, which is larger in frontally-looking species than in laterally-looking species. No sex differences in callosal size were detected in any of the species examined. These findings are discussed in the light of possible developmental and functional correlates of the variability observed.
Copyright (R) 2000 S. Karger AG, Basel
Publication Date: 2000-04-25 PubMed ID: 10773624DOI: 10.1159/000006640Google Scholar: Lookup
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- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research article conducted a thorough morphometric analysis on the corpus callosum (a dense region of nerve fibers in the brain) in various species including rat, rabbit, cat, dog, horse, cow, and human. The findings show that the size of the corpus callosum largely depends on the brain weight, and this correlation tends to weaken within the same species.
Understanding Corpus Callosum Morphometry
- The study involved a comprehensive morphometric analysis of the corpus callosum in different species. Morphometric analysis is a quantitative study of forms. In this case, it was used to measure the size of the corpus callosum.
- The corpus callosum comprises a dense bundle of nerve fibers in the brain. It facilitates communication between the left and right cerebral hemispheres, thus playing an essential role in integrating motor, sensory, and cognitive functions.
Cross-species and Intraspecies Analysis
- For cross-species comparisons, researchers found a significant, albeit not directly proportional, relationship between the size of the corpus callosum and brain weight. This means that as the brain weight increases, the size of the corpus callosum also tends to increase, but not necessarily in a direct linear fashion.
- In intraspecies comparisons, where the analysis was conducted within the same species, this strong correlation tended to lose its significance. This finding agrees with other morphometric studies, which have pointed toward decreasing correlations between morphometric variables in within-species comparisons.
Other Key Findings and Observations
- The study also discovered species differences in the relative size of some segments of the corpus callosum. This was seen particularly in the posterior third of the callosum, which was found to be larger in frontally-looking species compared to laterally-looking ones.
- Importantly, the research detected no sex differences in the size of the corpus callosum across the studied species. This implies that gender does not noticeably influence the size of the corpus callosum.
- The results of the study are discussed in connection with potential developmental and functional correlations of the observed variability. This could provide insightful information on how variations in corpus callosum size might be linked to different developmental and functional attributes in different species.
Cite This Article
APA
Olivares R, Michalland S, Aboitiz F.
(2000).
Cross-species and intraspecies morphometric analysis of the corpus callosum.
Brain Behav Evol, 55(1), 37-43.
https://doi.org/10.1159/000006640 Publication
Researcher Affiliations
- Facultad de Ciencias Veterinarias, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
MeSH Terms
- Adult
- Aged
- Animals
- Body Weight / physiology
- Cats
- Cattle
- Corpus Callosum / anatomy & histology
- Corpus Callosum / physiology
- Dogs
- Female
- Horses
- Humans
- Male
- Middle Aged
- Organ Size / physiology
- Rabbits
- Rats
- Sex Characteristics
- Species Specificity
- Tissue Fixation
Citations
This article has been cited 14 times.- Gast H, Horowitz A, Krupnik R, Barazany D, Lifshits S, Ben-Amitay S, Assaf Y. A Method for In-Vivo Mapping of Axonal Diameter Distributions in the Human Brain Using Diffusion-Based Axonal Spectrum Imaging (AxSI).. Neuroinformatics 2023 Jul;21(3):469-482.
- Kellmeyer P, Vry MS, Ball T. A transcallosal fibre system between homotopic inferior frontal regions supports complex linguistic processing.. Eur J Neurosci 2019 Nov;50(10):3544-3556.
- Wright AK, Theilmann RJ, Ridgway SH, Scadeng M. Diffusion tractography reveals pervasive asymmetry of cerebral white matter tracts in the bottlenose dolphin (Tursiops truncatus).. Brain Struct Funct 2018 May;223(4):1697-1711.
- Atkinson EG, Rogers J, Cheverud JM. Evolutionary and developmental implications of asymmetric brain folding in a large primate pedigree.. Evolution 2016 Mar;70(3):707-15.
- Pesaresi M, Soon-Shiong R, French L, Kaplan DR, Miller FD, Paus T. Axon diameter and axonal transport: In vivo and in vitro effects of androgens.. Neuroimage 2015 Jul 15;115:191-201.
- Shen K, Mišić B, Cipollini BN, Bezgin G, Buschkuehl M, Hutchison RM, Jaeggi SM, Kross E, Peltier SJ, Everling S, Jonides J, McIntosh AR, Berman MG. Stable long-range interhemispheric coordination is supported by direct anatomical projections.. Proc Natl Acad Sci U S A 2015 May 19;112(20):6473-8.
- Falangola MF, Guilfoyle DN, Tabesh A, Hui ES, Nie X, Jensen JH, Gerum SV, Hu C, LaFrancois J, Collins HR, Helpern JA. Histological correlation of diffusional kurtosis and white matter modeling metrics in cuprizone-induced corpus callosum demyelination.. NMR Biomed 2014 Aug;27(8):948-57.
- Casanova MF. Cortical organization: a description and interpretation of anatomical findings based on systems theory.. Transl Neurosci 2010;1(1):62-71.
- Casanova MF, El-Baz A, Elnakib A, Giedd J, Rumsey JM, Williams EL, Switala AE. Corpus Callosum Shape Analysis with Application to Dyslexia.. Transl Neurosci 2010 Jun;1(2):124-130.
- Paul LK. Developmental malformation of the corpus callosum: a review of typical callosal development and examples of developmental disorders with callosal involvement.. J Neurodev Disord 2011 Mar;3(1):3-27.
- Casanova MF, El-Baz A, Elnakib A, Switala AE, Williams EL, Williams DL, Minshew NJ, Conturo TE. Quantitative analysis of the shape of the corpus callosum in patients with autism and comparison individuals.. Autism 2011 Mar;15(2):223-38.
- Barazany D, Basser PJ, Assaf Y. In vivo measurement of axon diameter distribution in the corpus callosum of rat brain.. Brain 2009 May;132(Pt 5):1210-20.
- Casanova MF, El-Baz A, Mott M, Mannheim G, Hassan H, Fahmi R, Giedd J, Rumsey JM, Switala AE, Farag A. Reduced gyral window and corpus callosum size in autism: possible macroscopic correlates of a minicolumnopathy.. J Autism Dev Disord 2009 May;39(5):751-64.
- Hopkins WD, Dunham L, Cantalupo C, Taglialatela J. The Association between handedness, brain asymmetries, and corpus callosum size in chimpanzees (Pan troglodytes).. Cereb Cortex 2007 Aug;17(8):1757-65.
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