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Home / Equine Research Bank / Parasit Vectors / Cyathostomin resistance to moxidectin and combinations of an...
Parasites & vectors2021; 14(1); 597; doi: 10.1186/s13071-021-05103-8

Cyathostomin resistance to moxidectin and combinations of anthelmintics in Australian horses.

Abstract: Cyathostomins are the most important and common parasitic nematodes of horses, with > 50 species known to occur worldwide. The frequent and indiscriminate use of anthelmintics has resulted in the development of anthelmintic resistance (AR) in horse nematodes. In this study we assessed the efficacy of commonly used anthelmintics against cyathostomins in Australian thoroughbred horses. Methods: Two drug efficacy trials per farm were conducted on two thoroughbred horse farms in the state of Victoria, Australia. In the first trial, the horses on Farm A were treated with single and combinations of anthelmintics, including oxfendazole (OFZ), abamectin (ABM), abamectin and morantel (ABM + MOR), moxidectin (MOX) and oxfendazole and pyrantel (OFZ + PYR), at the recommended doses, whereas the horses on Farm B only received MOX, at the recommended dose. The faecal egg count reduction test (FECRT) was used to determine the efficacy and egg reappearance period (ERP) of anthelmintics. Based on the results of the first trial, the efficacies of MOX and a combination of ABM + MOR were reassessed to confirm their activities against cyathostomins. Results: Of the five anthelmintic products tested on Farm A, resistance against OFZ, ABM and OFZ + PYR was found, with efficacies of - 41% (- 195% lower confidence limit [LCL]), 73% (60% LCL) and 82% (66% LCL) at 2 weeks post-treatment, respectively. The FECRT showed high efficacies of MOX and ABM + MOR (100%) at 2 week post-treatment and shortened ERPs for these anthelmintics (ABM + MOR: 4 weeks; MOX: 5 weeks). Resistance to MOX was found on Farm B, with a reduced efficacy of 90% (70% LCL) and 89% (82% LCL) at 2 weeks post-treatment in trials one and two, respectively. Conclusions: This study provides the first evidence of MOX- and multidrug-resistant (ABM and combinations of anthelmintics) cyathostomins in Australia and indicates the need for continuous surveillance of the efficacy of currently effective anthelmintics and large-scale investigations to assess the ERP for various anthelmintics.
© 2021. The Author(s).
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Publication Date: 2021-12-04 PubMed ID: 34863271PubMed Central: PMC8645149DOI: 10.1186/s13071-021-05103-8Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research study investigates the resistance of a common horse parasite (Cyathostomins) to various anti-parasitic drugs in Australian horses and finds initial evidence of multidrug resistance, suggesting the need for continued surveillance and study.

Introduction

  • Cyathostomins are noted as being the most prevalent and damaging parasitic nematodes affecting horses, having over 50 species that occur globally.
  • The frequent and unchecked use of anti-parasitic or anthelmintic drugs has led to a growing resistance in horse nematodes.
  • This study was undertaken to analyze the effectiveness of commonly used anthelmintics against cyathostomins in Australian thoroughbred horses.

Methodology

  • The research took place on two horse farms in Victoria, Australia with two drug efficacy trials performed per farm.
  • Horses on Farm A were treated with both single and combination therapies of anthelmintics, including oxfendazole (OFZ), abamectin (ABM), moxidectin (MOX), and combinations of molupectrenone and pyrantel.
  • Contrarily, horses on Farm B were only treated with MOX.
  • The faecal egg count reduction test (FECRT) was employed to determine the efficacy and egg reappearance period (ERP) of the anthelmintics.

Results

  • Of the five anthelmintic treatments trialed on Farm A, resistance was detected against OFZ, ABM, and the OFZ + PYR combination therapies, yielding efficacy levels of -41%, 73%, and 82% respectively after 2 weeks of treatment.
  • On the other hand, MOX, as well as the ABM + MOR combination treatment, showed high efficacy (100%) within a 2-week post-treatment window.
  • Resistance to MOX was identified on Farm B, showing a diminished efficacy at 90% and 89% in the two respective trials.

Conclusions

  • This study is the first to showcase evidence of MOX- and multi-drug-resistant cyathostomins in Australia.
  • The findings underscore the urgency for continued monitoring of the performance of current anthelmintics and more extensive investigations to determine the egg reappearance period for various anthelmintics.

Cite This Article

APA
Abbas G, Ghafar A, Hurley J, Bauquier J, Beasley A, Wilkes EJA, Jacobson C, El-Hage C, Cudmore L, Carrigan P, Tennent-Brown B, Gauci CG, Nielsen MK, Hughes KJ, Beveridge I, Jabbar A. (2021). Cyathostomin resistance to moxidectin and combinations of anthelmintics in Australian horses. Parasit Vectors, 14(1), 597. https://doi.org/10.1186/s13071-021-05103-8

Publication

Parasites & vectors
ISSN: 1756-3305
NlmUniqueID: 101462774
Country: England
Language: English
Volume: 14
Issue: 1
Pages: 597
PII: 597

Researcher Affiliations

Abbas, Ghazanfar
  • Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Werribee, VIC, Australia.
Ghafar, Abdul
  • Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Werribee, VIC, Australia.
Hurley, John
  • Swettenham Stud, Nagambie, VIC, Australia.
Bauquier, Jenni
  • Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Werribee, VIC, Australia.
Beasley, Anne
  • School of Agriculture and Food Sciences, University of Queensland, Gatton, QLD, Australia.
Wilkes, Edwina J A
  • School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, NSW, Australia.
Jacobson, Caroline
  • Centre for Animal Production and Health, Murdoch University, Murdoch, WA, Australia.
El-Hage, Charles
  • Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Werribee, VIC, Australia.
Cudmore, Lucy
  • Scone Equine Hospital, Scone, NSW, Australia.
Carrigan, Peter
  • Scone Equine Hospital, Scone, NSW, Australia.
Tennent-Brown, Brett
  • Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Werribee, VIC, Australia.
Gauci, Charles G
  • Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Werribee, VIC, Australia.
Nielsen, Martin K
  • Department of Veterinary Science, M.H. Gluck Equine Research Center, University of Kentucky, Lexington, KY, USA.
Hughes, Kristopher J
  • School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, NSW, Australia.
Beveridge, Ian
  • Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Werribee, VIC, Australia.
Jabbar, Abdul
  • Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Werribee, VIC, Australia. jabbara@unimelb.edu.au.

MeSH Terms

  • Animals
  • Anthelmintics / pharmacology
  • Benzimidazoles / pharmacology
  • Drug Resistance, Multiple
  • Epidemiological Monitoring
  • Face / parasitology
  • Farms
  • Female
  • Horse Diseases / drug therapy
  • Horse Diseases / epidemiology
  • Horse Diseases / parasitology
  • Horses
  • Ivermectin / analogs & derivatives
  • Ivermectin / pharmacology
  • Macrolides / pharmacology
  • Male
  • Morantel / pharmacology
  • Nematoda / drug effects
  • Nematode Infections / drug therapy
  • Nematode Infections / epidemiology
  • Nematode Infections / parasitology
  • Nematode Infections / veterinary
  • Parasite Egg Count / veterinary

Conflict of Interest Statement

The authors are members of the Australian Equine Parasitology Advisory Panel (AEPAP) supported by AgriFutures Australia and Boehringer Ingelheim Animal Health Australia. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

References

This article includes 52 references
  1. Lichtenfels JR, Kharchenko VA, Dvojnos GM. Illustrated identification keys to strongylid parasites (Strongylidae: Nematoda) of horses, zebras and asses (Equidae).. Vet Parasitol 2008 Sep 15;156(1-2):4-161.
    pubmed: 18603375doi: 10.1016/j.vetpar.2008.04.026google scholar: lookup
  2. Corning S. Equine cyathostomins: a review of biology, clinical significance and therapy.. Parasit Vectors 2009 Sep 25;2 Suppl 2(Suppl 2):S1.
    pmc: PMC2751837pubmed: 19778462doi: 10.1186/1756-3305-2-s2-s1google scholar: lookup
  3. Reid SW, Mair TS, Hillyer MH, Love S. Epidemiological risk factors associated with a diagnosis of clinical cyathostomiasis in the horse.. Equine Vet J 1995 Mar;27(2):127-30.
    pubmed: 7607145doi: 10.1111/j.2042-3306.1995.tb03048.xgoogle scholar: lookup
  4. Love S, Murphy D, Mellor D. Pathogenicity of cyathostome infection.. Vet Parasitol 1999 Aug 31;85(2-3):113-21; discussion 121-2, 215-25.
    pubmed: 10485358doi: 10.1016/s0304-4017(99)00092-8google scholar: lookup
  5. Matthews JB. Anthelmintic resistance in equine nematodes.. Int J Parasitol Drugs Drug Resist 2014 Dec;4(3):310-5.
    pmc: PMC4266799pubmed: 25516842doi: 10.1016/j.ijpddr.2014.10.003google scholar: lookup
  6. Peregrine AS, Molento MB, Kaplan RM, Nielsen MK. Anthelmintic resistance in important parasites of horses: does it really matter?. Vet Parasitol 2014 Mar 17;201(1-2):1-8.
    pubmed: 24485565doi: 10.1016/j.vetpar.2014.01.004google scholar: lookup
  7. Tzelos T, Barbeito JS, Nielsen MK, Morgan ER, Hodgkinson JE, Matthews JB. Strongyle egg reappearance period after moxidectin treatment and its relationship with management factors in UK equine populations.. Vet Parasitol 2017 Apr 15;237:70-76.
    pubmed: 28249767doi: 10.1016/j.vetpar.2017.02.018google scholar: lookup
  8. Nielsen MK, Banahan M, Kaplan RM. Importation of macrocyclic lactone resistant cyathostomins on a US thoroughbred farm.. Int J Parasitol Drugs Drug Resist 2020 Dec;14:99-104.
    pmc: PMC7548974pubmed: 33022574doi: 10.1016/j.ijpddr.2020.09.004google scholar: lookup
  9. Edward CL, Hoffmann AA. Ivermectin resistance in a horse in Australia.. Vet Rec 2008 Jan 12;162(2):56-7.
    pubmed: 18192659doi: 10.1136/vr.162.2.56google scholar: lookup
  10. Molento MB, Antunes J, Bentes RN, Coles GC. Anthelmintic resistant nematodes in Brazilian horses.. Vet Rec 2008 Mar 22;162(12):384-5.
    pubmed: 18359933doi: 10.1136/vr.162.12.384google scholar: lookup
  11. Milillo P, Boeckh A, Cobb R, Otranto D, Lia RP, Perrucci S, di Regalbono AF, Beraldo P, von Samson-Himmelstjerna G, Demeler J, Bartolini R, Traversa D. Faecal Cyathostomin Egg Count distribution and efficacy of anthelmintics against cyathostomins in Italy: a matter of geography?. Parasit Vectors 2009 Sep 25;2 Suppl 2(Suppl 2):S4.
    pmc: PMC2751840pubmed: 19778465doi: 10.1186/1756-3305-2-s2-s4google scholar: lookup
  12. Traversa D, von Samson-Himmelstjerna G, Demeler J, Milillo P, Schürmann S, Barnes H, Otranto D, Perrucci S, di Regalbono AF, Beraldo P, Boeckh A, Cobb R. Anthelmintic resistance in cyathostomin populations from horse yards in Italy, United Kingdom and Germany.. Parasit Vectors 2009 Sep 25;2 Suppl 2(Suppl 2):S2.
    pmc: PMC2751838pubmed: 19778463doi: 10.1186/1756-3305-2-s2-s2google scholar: lookup
  13. Näreaho A, Vainio K, Oksanen A. Impaired efficacy of ivermectin against Parascaris equorum, and both ivermectin and pyrantel against strongyle infections in trotter foals in Finland.. Vet Parasitol 2011 Dec 15;182(2-4):372-7.
    pubmed: 21689886doi: 10.1016/j.vetpar.2011.05.045google scholar: lookup
  14. Canever RJ, Braga PR, Boeckh A, Grycajuck M, Bier D, Molento MB. Lack of Cyathostomin sp. reduction after anthelmintic treatment in horses in Brazil.. Vet Parasitol 2013 May 1;194(1):35-9.
    pubmed: 23318166doi: 10.1016/j.vetpar.2012.12.020google scholar: lookup
  15. Molena RA, Peachey LE, Di Cesare A, Traversa D, Cantacessi C. Cyathostomine egg reappearance period following ivermectin treatment in a cohort of UK Thoroughbreds.. Parasit Vectors 2018 Jan 25;11(1):61.
    pmc: PMC5785887pubmed: 29370872doi: 10.1186/s13071-018-2638-6google scholar: lookup
  16. von Samson-Himmelstjerna G, Fritzen B, Demeler J, Schürmann S, Rohn K, Schnieder T, Epe C. Cases of reduced cyathostomin egg-reappearance period and failure of Parascaris equorum egg count reduction following ivermectin treatment as well as survey on pyrantel efficacy on German horse farms.. Vet Parasitol 2007 Mar 15;144(1-2):74-80.
    pubmed: 17112667doi: 10.1016/j.vetpar.2006.09.036google scholar: lookup
  17. Ionita M, Howe DK, Lyons ET, Tolliver SC, Kaplan RM, Mitrea IL, Yeargan M. Use of a reverse line blot assay to survey small strongyle (Strongylida: Cyathostominae) populations in horses before and after treatment with ivermectin.. Vet Parasitol 2010 Mar 25;168(3-4):332-7.
    pubmed: 20045254doi: 10.1016/j.vetpar.2009.11.021google scholar: lookup
  18. Rossano MG, Smith AR, Lyons ET. Shortened strongyle-type egg reappearance periods in naturally infected horses treated with moxidectin and failure of a larvicidal dose of fenbendazole to reduce fecal egg counts.. Vet Parasitol 2010 Oct 29;173(3-4):349-52.
    pubmed: 20675055doi: 10.1016/j.vetpar.2010.07.001google scholar: lookup
  19. Geurden T, van Doorn D, Claerebout E, Kooyman F, De Keersmaecker S, Vercruysse J, Besognet B, Vanimisetti B, di Regalbono AF, Beraldo P, Di Cesare A, Traversa D. Decreased strongyle egg re-appearance period after treatment with ivermectin and moxidectin in horses in Belgium, Italy and The Netherlands.. Vet Parasitol 2014 Aug 29;204(3-4):291-6.
    pubmed: 24880643doi: 10.1016/j.vetpar.2014.04.013google scholar: lookup
  20. Relf VE, Lester HE, Morgan ER, Hodgkinson JE, Matthews JB. Anthelmintic efficacy on UK Thoroughbred stud farms.. Int J Parasitol 2014 Jul;44(8):507-14.
    pubmed: 24746779doi: 10.1016/j.ijpara.2014.03.006google scholar: lookup
  21. Fischer JK, Hinney B, Denwood MJ, Traversa D, von Samson-Himmelstjerna G, Clausen PH. Efficacy of selected anthelmintic drugs against cyathostomins in horses in the federal state of Brandenburg, Germany.. Parasitol Res 2015 Dec;114(12):4441-50.
    pubmed: 26337266doi: 10.1007/s00436-015-4685-7google scholar: lookup
  22. Beasley AM, Kotze AC, Allen K, Coleman GT. A survey of macrocyclic lactone efficacy in Australian cyathostomin populations.. Vet Parasitol Reg Stud Reports 2017 May;8:127-132.
    pubmed: 31014629doi: 10.1016/j.vprsr.2017.03.009google scholar: lookup
  23. Barnes EH, Dobson RJ, Barger IA. Worm control and anthelmintic resistance: adventures with a model.. Parasitol Today 1995 Feb;11(2):56-63.
    pubmed: 15275374doi: 10.1016/0169-4758(95)80117-0google scholar: lookup
  24. Leathwick DM. Modelling the benefits of a new class of anthelmintic in combination.. Vet Parasitol 2012 May 4;186(1-2):93-100.
    pubmed: 22169403doi: 10.1016/j.vetpar.2011.11.050google scholar: lookup
  25. Entrocasso C, Alvarez L, Manazza J, Lifschitz A, Borda B, Virkel G, Mottier L, Lanusse C. Clinical efficacy assessment of the albendazole-ivermectin combination in lambs parasitized with resistant nematodes.. Vet Parasitol 2008 Aug 17;155(3-4):249-56.
    pubmed: 18571329doi: 10.1016/j.vetpar.2008.04.015google scholar: lookup
  26. Le Jambre L, Martin P, Johnston A. Efficacy of combination anthelmintics against multiple resistant strains of sheep nematodes.. Anim Prod Sci 2010;50:946–952.
  27. Kaplan R, West E, Norat-Collazo L, Vargas J. A combination treatment strategy using pyrantel pamoate and oxibendazole demonstrates additive effects for controlling equine cyathostomins.. Equine Vet Educ 2014;26:485–491.
  28. Scare JA, Lyons ET, Wielgus KM, Nielsen MK. Combination deworming for the control of double-resistant cyathostomin parasites - short and long term consequences.. Vet Parasitol 2018 Feb 15;251:112-118.
    pubmed: 29426466doi: 10.1016/j.vetpar.2018.01.010google scholar: lookup
  29. Scare JA, Leathwick DM, Sauermann CW, Lyons ET, Steuer AE, Jones BA, Clark M, Nielsen MK. Dealing with double trouble: Combination deworming against double-drug resistant cyathostomins.. Int J Parasitol Drugs Drug Resist 2020 Apr;12:28-34.
    pmc: PMC7139983pubmed: 31883485doi: 10.1016/j.ijpddr.2019.12.002google scholar: lookup
  30. Gordon HM, Whitlock HV. A new technique for counting nematode eggs in sheep faeces.. J Counc Sci Ind Res 1939;12:50–52.
  31. Nielsen MK, Mittel L, Grice A, Erskine M, Graves E, Vaala W. AAEP parasite control guidelines.. Lexington: American Association of Equine Practitioners. 2019.
  32. Torgerson PR, Paul M, Furrer R. Evaluating faecal egg count reduction using a specifically designed package "eggCounts" in R and a user friendly web interface.. Int J Parasitol 2014 Apr;44(5):299-303.
    pubmed: 24556564doi: 10.1016/j.ijpara.2014.01.005google scholar: lookup
  33. Coles GC, Bauer C, Borgsteede FH, Geerts S, Klei TR, Taylor MA, Waller PJ. World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) methods for the detection of anthelmintic resistance in nematodes of veterinary importance.. Vet Parasitol 1992 Sep;44(1-2):35-44.
    pubmed: 1441190doi: 10.1016/0304-4017(92)90141-ugoogle scholar: lookup
  34. Levecke B, Kaplan RM, Thamsborg SM, Torgerson PR, Vercruysse J, Dobson RJ. How to improve the standardization and the diagnostic performance of the fecal egg count reduction test?. Vet Parasitol 2018 Apr 15;253:71-78.
    pubmed: 29605007doi: 10.1016/j.vetpar.2018.02.004google scholar: lookup
  35. Campbell AJ, Gasser RB, Chilton NB. Differences in a ribosomal DNA sequence of Strongylus species allows identification of single eggs.. Int J Parasitol 1995 Mar;25(3):359-65.
    pubmed: 7601594doi: 10.1016/0020-7519(94)00116-6google scholar: lookup
  36. Anonymous. Equest®plustape, overview.. 2020.
  37. Trawford AF, Burden F, Hodgkinson J. Suspected moxidectin resistance in cyathostomes in two donkeys herds at The Donkey Sanctuary, UK.. Proceedings of the 20th international conference of the World Association for the Advancement of Veterinary Parasitology 2005;20(196).
  38. Buono F, Roncoroni C, Pacifico L, Piantedosi D, Neola B, Barile VL. Cyathostominae egg reappearance period after treatment with major horse anthelmintics in donkeys.. J Equine Vet Sci 2018;65:6–11.
  39. Flores AG, Osmari V, Ramos F, Marques CB, Ramos DJ, Botton SA, Vogel FSF, Sangioni LA. Multiple resistance in equine cyathostomins: a case study from military establishments in Rio Grande do Sul, Brazil.. Rev Bras Parasitol Vet 2020;29(3):e003820.
    pubmed: 33027421doi: 10.1590/s1984-29612020086google scholar: lookup
  40. Gilleard JS, Beech RN. Population genetics of anthelmintic resistance in parasitic nematodes.. Parasitology 2007;134(Pt 8):1133-47.
    pubmed: 17608973doi: 10.1017/s0031182007000066google scholar: lookup
  41. Shalaby HA. Anthelmintics Resistance; How to Overcome it?. Iran J Parasitol 2013 Jan;8(1):18-32.
    pmc: PMC3655236pubmed: 23682256
  42. Nielsen MK, Sauermann CW, Leathwick DM. The effect of climate, season, and treatment intensity on anthelmintic resistance in cyathostomins: A modelling exercise.. Vet Parasitol 2019 May;269:7-12.
    pubmed: 31079830doi: 10.1016/j.vetpar.2019.04.003google scholar: lookup
  43. Bairden K, Brown SR, McGoldrick J, Parker LD, Talty PJ. Efficacy of moxidectin 2 per cent gel against naturally acquired strongyle infections in horses, with particular reference to larval cyathostomes.. Vet Rec 2001 Feb 3;148(5):138-41.
    pubmed: 11271915doi: 10.1136/vr.148.5.138google scholar: lookup
  44. Coles GC. Sustainable use of anthelmintics in grazing animals.. Vet Rec 2002 Aug 10;151(6):165-9.
    pubmed: 12201258doi: 10.1136/vr.151.6.165google scholar: lookup
  45. Bairden K, Davies HS, Gibson NR, Hood AJ, Parker LD. Efficacy of moxidectin 2 per cent oral gel against cyathostomins, particularly third-stage inhibited larvae, in horses.. Vet Rec 2006 Jun 3;158(22):766-7.
    pubmed: 16751314doi: 10.1136/vr.158.22.766google scholar: lookup
  46. Rolfe PF, Dawson KL. The efficacy of a combination anthelmintic against oxibendazole resistant small strongyles, large strongyles and ascarids in horses.. Aust Vet J 1994 Sep;71(9):304-6.
    pubmed: 7818443doi: 10.1111/j.1751-0813.1994.tb03453.xgoogle scholar: lookup
  47. Pook JF, Power ML, Sangster NC, Hodgson JL, Hodgson DR. Evaluation of tests for anthelmintic resistance in cyathostomes.. Vet Parasitol 2002 Jul 2;106(4):331-43.
    pubmed: 12079739doi: 10.1016/s0304-4017(02)00093-6google scholar: lookup
  48. Kaplan RM, Klei TR, Lyons ET, Lester G, Courtney CH, French DD, Tolliver SC, Vidyashankar AN, Zhao Y. Prevalence of anthelmintic resistant cyathostomes on horse farms.. J Am Vet Med Assoc 2004 Sep 15;225(6):903-10.
    pubmed: 15485051doi: 10.2460/javma.2004.225.903google scholar: lookup
  49. Kuzmina TA, Kharchenko VO. Anthelmintic resistance in cyathostomins of brood horses in Ukraine and influence of anthelmintic treatments on strongylid community structure.. Vet Parasitol 2008 Jul 4;154(3-4):277-88.
    pubmed: 18485600doi: 10.1016/j.vetpar.2008.03.024google scholar: lookup
  50. Bellaw JL, Krebs K, Reinemeyer CR, Norris JK, Scare JA, Pagano S, Nielsen MK. Anthelmintic therapy of equine cyathostomin nematodes - larvicidal efficacy, egg reappearance period, and drug resistance.. Int J Parasitol 2018 Feb;48(2):97-105.
    pubmed: 29050919doi: 10.1016/j.ijpara.2017.08.009google scholar: lookup
  51. van Doorn DC, Ploeger HW, Eysker M, Geurden T, Wagenaar JA, Kooyman FN. Cylicocyclus species predominate during shortened egg reappearance period in horses after treatment with ivermectin and moxidectin.. Vet Parasitol 2014 Dec 15;206(3-4):246-52.
    pubmed: 25458565doi: 10.1016/j.vetpar.2014.10.004google scholar: lookup
  52. Conder GA, Thompson DP, Johnson SS. Demonstration of co-resistance of Haemonchus contortus to ivermectin and moxidectin.. Vet Rec 1993 Jun 26;132(26):651-2.
    pubmed: 8362470doi: 10.1136/vr.132.26.651google scholar: lookup

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    doi: 10.1016/j.ijpddr.2023.06.002pubmed: 37354849google scholar: lookup
  2. Bull KE, Allen KJ, Hodgkinson JE, Peachey LE. The first report of macrocyclic lactone resistant cyathostomins in the UK. Int J Parasitol Drugs Drug Resist 2023 Apr;21:125-130.
    doi: 10.1016/j.ijpddr.2023.03.001pubmed: 36940551google scholar: lookup
  3. Boelow H, Krücken J, von Samson-Himmelstjerna G. Epidemiological study on factors influencing the occurrence of helminth eggs in horses in Germany based on sent-in diagnostic samples. Parasitol Res 2023 Mar;122(3):749-767.
    doi: 10.1007/s00436-022-07765-4pubmed: 36627515google scholar: lookup
  4. Macdonald SL, Abbas G, Ghafar A, Gauci CG, Bauquier J, El-Hage C, Tennent-Brown B, Wilkes EJA, Beasley A, Jacobson C, Cudmore L, Carrigan P, Hurley J, Beveridge I, Hughes KJ, Nielsen MK, Jabbar A. Egg reappearance periods of anthelmintics against equine cyathostomins: The state of play revisited. Int J Parasitol Drugs Drug Resist 2023 Apr;21:28-39.
    doi: 10.1016/j.ijpddr.2022.12.002pubmed: 36543048google scholar: lookup
  5. Klass LG, Krücken J, Mbedi S, Sparmann S, Schenk T, Andreotti S, von Samson-Himmelstjerna G. Characterizing mixed strongyle infections in foals and broodmares using cytochrome c oxidase subunit I deep amplicon sequencing. Parasit Vectors 2026 Jan 3;19(1):65.
    doi: 10.1186/s13071-025-07192-1pubmed: 41484633google scholar: lookup
  6. Abbas G, Nielsen MK, E-Hage C, Ghafar A, Beveridge I, Bauquier J, Beasley A, Wilkes EJA, Carrigan P, Cudmore L, Jacobson C, Hughes KJ, Jabbar A. Recent advances in intestinal helminth parasites of horses in the Asia-Pacific region: Current trends, challenges and future directions. Int J Parasitol Drugs Drug Resist 2025 Dec;29:100622.
    doi: 10.1016/j.ijpddr.2025.100622pubmed: 41135277google scholar: lookup
  7. Šarkūnas M, Schwahn A, Suleimanova K. A pilot study on the potency of injectable vs. oral moxidectin formulation to suppress strongyle egg excretion in horses at twice lower dose. Helminthologia 2025 Jun;62(2):87-94.
    doi: 10.2478/helm-2025-0018pubmed: 41058774google scholar: lookup
  8. Cabaret J. Independent Development of Resistance to Main Classes of Anthelmintics by Gastrointestinal Nematodes of Ruminants and Horses. Pathogens 2025 Sep 5;14(9).
    doi: 10.3390/pathogens14090898pubmed: 41011797google scholar: lookup
  9. Beasley A, Abbas G, Hughes K, El-Hage C, Jacobson C, Bauquier J, Wilkes E, Carrigan P, Cudmore L, Hurley J, Beveridge I, Nielsen M, Jabbar A. Australian guidelines for equine internal parasite management. Aust Vet J 2025 Apr;103(4):151-158.
    doi: 10.1111/avj.13424pubmed: 39837536google scholar: lookup
  10. Bull KE, Hodgkinson J, Allen K, Poissant J, Peachey LE. Quantitative DNA metabarcoding reveals species composition of a macrocyclic lactone and pyrantel resistant cyathostomin population in the UK. Int J Parasitol Drugs Drug Resist 2025 Apr;27:100576.
    doi: 10.1016/j.ijpddr.2024.100576pubmed: 39778419google scholar: lookup
  11. Elghryani N, Lawlor A, McOwan T, de Waal T. Unravelling the Effectiveness of Anthelmintic Treatments on Equine Strongyles on Irish Farms. Animals (Basel) 2024 Jul 2;14(13).
    doi: 10.3390/ani14131958pubmed: 38998069google scholar: lookup
  12. Abbas G, Stevenson MA, Bauquier J, Beasley A, Jacobson C, El-Hage C, Wilkes EJA, Carrigan P, Cudmore L, Hurley J, Beveridge I, Nielsen MK, Hughes KJ, Jabbar A. Assessment of worm control practices recommended by equine veterinarians in Australia. Front Vet Sci 2023;10:1305360.
    doi: 10.3389/fvets.2023.1305360pubmed: 38026649google scholar: lookup
  13. Matthews JB, Peczak N, Lightbody KL. The Use of Innovative Diagnostics to Inform Sustainable Control of Equine Helminth Infections. Pathogens 2023 Oct 11;12(10).
    doi: 10.3390/pathogens12101233pubmed: 37887749google scholar: lookup
  14. Buono F, Veneziano V, Veronesi F, Molento MB. Horse and donkey parasitology: differences and analogies for a correct diagnostic and management of major helminth infections. Parasitology 2023 Oct;150(12):1119-1138.
    doi: 10.1017/S0031182023000525pubmed: 37221816google scholar: lookup
  15. Nielsen MK. Anthelmintic resistance in equine nematodes: Current status and emerging trends. Int J Parasitol Drugs Drug Resist 2022 Dec;20:76-88.
    doi: 10.1016/j.ijpddr.2022.10.005pubmed: 36342004google scholar: lookup
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