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Cyclic and pathologic changes of the mare endometrium as detected by biopsy, with a note on early embryonic death.
Abstract: Normal histologic changes that occurred in concert with the ovarian cycle were evaluated. When combined with behavioral and physical findings, this evaluation enabled determination when there was synchrony between ovarian steroids (estrogen and progesterone) and their target tissues of endometrium. A system for classification as well as definitions of patterns types and degrees of severity of inflammatory and fibrotic changes was developed to facilitate a uniform system for description and communication. An attempt was made to relate the pathologic changes to their effect on fertility when fertility was defined as the ability to conceive, maintain, and deliver a live foal. This was done by dividing the types of endometrium into 3 categories, based on increasing degrees of extensiveness and severity of the various changes, and it was possible to show a high correlation of category to foaling rate. Embryonic and fetal loss from endometria with widespread periglandular fibrosis was observed. This was considered to be the major diagnosable cause of this type of reproductive failure.
Publication Date: 1978-02-01 PubMed ID: 621166 The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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The study delves into the regular histologic changes associated with the ovarian cycle and observes their connection with reproductive problems in horses, particularly early embryonic death. Using biopsy methods, the research develops a classification system to describe the variations and severity of inflammatory and fibrotic changes in the mare’s endometrium.
Understanding Normal Histologic Changes
- The study began by examining the regular histologic transformations that coincide with a mare’s ovarian cycle. These physiological changes were assessed in conjunction with behavioral and physical observations.
- The understanding of these normal changes is critical for determining when there is synchronization between ovarian steroids (i.e., estrogen and progesterone) and their target endometrium tissues. This synchrony is vital for the optimal reproductive health of the mare.
Developing a Classification System
- Crucial to this study was the development of a unified system for classifying and defining the varying types and severity levels of inflammatory and fibrotic changes identified in the mare’s endometrium.
- This systematic method of description facilitates clear, concise communication among researchers and practitioners in the field.
Linking Pathologic Changes to Fertility
- The researchers aimed to connect these pathologic changes in the endometrium to their impact on a mare’s fertility, defined in this context as the ability to conceive, carry, and deliver a live foal.
- To achieve this, they categorized the endometrium types into three groups, each representing a different level of extensiveness and severity of the identified changes. A strong correlation emerged between these categories and foaling rates.
Observations on Embryonic and Fetal Loss
- The study found that mares with widespread periglandular fibrosis of the endometrium suffered from embryonic or fetal loss.
- This condition was deemed the most predominating diagnosable cause of such reproductive failures.
Cite This Article
APA
Kenney RM.
(1978).
Cyclic and pathologic changes of the mare endometrium as detected by biopsy, with a note on early embryonic death.
J Am Vet Med Assoc, 172(3), 241-262.
Publication
Researcher Affiliations
MeSH Terms
- Abortion, Veterinary / pathology
- Animals
- Atrophy
- Bacterial Infections / pathology
- Bacterial Infections / veterinary
- Biopsy / methods
- Biopsy / veterinary
- Dilatation, Pathologic
- Embryo, Mammalian
- Endometrial Hyperplasia / pathology
- Endometrial Hyperplasia / veterinary
- Endometritis / pathology
- Endometritis / veterinary
- Endometrium / cytology
- Endometrium / pathology
- Estrus
- Female
- Fertility
- Fetal Death / pathology
- Fetal Death / veterinary
- Horse Diseases / pathology
- Horses / anatomy & histology
- Horses / physiology
- Hypertrophy
- Pregnancy
Citations
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