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Acta veterinaria Scandinavica1995; 36(2); 255-272; doi: 10.1186/BF03547694

D-dimer improves the prognostic value of combined clinical and laboratory data in equine gastrointestinal colic.

Abstract: The discriminating ability of 15 parameters alone or in combinations, including results from analysis of plasma endotoxin, the Nycomed plasma D-Dimer test and phospholipase A2, were analyzed to predict morbidity and mortality in equine gastrointestinal colic. Endotoxaemia was a characteristic feature of the colic horses. The problem of adequately predicting nonsurvivors among colic horses required several parameters to be included in the logistic model: if the "classical parameters", (heart rate, respiratory rate, PCV, anion gap) were included in the model, addition of plasma D-dimer, phospholipase A2, and Cl- significantly improved the predictive value of the logistic model. Increasing heart rate and D-dimer together with decreasing chloride was a risk factor for nonsurvival. The sensitivity of this three-parameter logistic model to predict nonsurvival was 78% and specificity 77%. The Nycomed D-Dimer test is recommended as a horse-site test to predict disseminated intravascular coagulation and nonsurvival in equine colic.
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Publication Date: 1995-01-01 PubMed ID: 7484552PubMed Central: PMC8095414DOI: 10.1186/BF03547694Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article explores how the use of a specific test (the Nycomed D-Dimer test) along with monitoring certain health parameters can help predict the severity and possible fatal outcomes of gastrointestinal colic in horses.

Study Overview

  • The researchers investigated the prognostic ability of 15 different parameters individually and in combination, to foresee the severity and potential mortality in horses suffering from gastrointestinal colic. These parameters included results from the analysis of plasma endotoxin, the Nycomed plasma D-Dimer test, and levels of phospholipase A2.
  • The presence of endotoxemia, a condition where endotoxins are present in the blood, was a notable feature among the studied horses afflicted with colic.
  • The goal of the study was to adequately predict the horses that may not survive the colic condition. To do this, several parameters were integrated into a specific logistic model.

Key Findings

  • Four ‘classical parameters’ (heart rate, respiratory rate, packed cell volume, anion gap) were initially included in the logistic model.
  • The addition of plasma D-Dimer, phospholipase A2, and Chloride significantly improved the predictive value of the logistic model.
  • Heart rate and D-dimer levels increasing, together with decreased chloride levels, were identified as risk factors for non-survival among these horses.
  • This three-parameter logistic model had a sensitivity (ability to correctly identify actual positive cases) of 78% and specificity (ability to correctly identify actual negative cases) of 77% for predicting non-survival.

Conclusions and Recommendation

  • The Nycomed D-Dimer test was recommended for onsite testing to predict cases of disseminated intravascular coagulation (abnormal clotting of blood) and non-survival in equine colic.

In conclusion, the research made advancements in predicting the outcome of horses diagnosed with gastrointestinal colic. Their model, which includes the use of the Nycomed D-Dimer test and consideration of changing health parameters, enhances the ability of veterinarians to foresee possible fatal results.

Cite This Article

APA
Sandholm M, Vidovic A, Puotunen-Reinert A, Sankari S, Nyholm K, Rita H. (1995). D-dimer improves the prognostic value of combined clinical and laboratory data in equine gastrointestinal colic. Acta Vet Scand, 36(2), 255-272. https://doi.org/10.1186/BF03547694

Publication

Acta veterinaria Scandinavica
ISSN: 0044-605X
NlmUniqueID: 0370400
Country: England
Language: English
Volume: 36
Issue: 2
Pages: 255-272

Researcher Affiliations

Sandholm, M
  • Department of Clinical Sciences, College of Veterinary Medicine, Helsinki, Finland.
Vidovic, A
    Puotunen-Reinert, A
      Sankari, S
        Nyholm, K
          Rita, H

            MeSH Terms

            • Animals
            • Biomarkers
            • Colic / blood
            • Colic / diagnosis
            • Colic / mortality
            • Colic / veterinary
            • Endotoxins / blood
            • Fibrin Fibrinogen Degradation Products / analysis
            • Fibrinogen / analysis
            • Gastrointestinal Diseases / blood
            • Gastrointestinal Diseases / diagnosis
            • Gastrointestinal Diseases / mortality
            • Gastrointestinal Diseases / veterinary
            • Heart Rate
            • Horse Diseases / blood
            • Horse Diseases / diagnosis
            • Horse Diseases / mortality
            • Horses
            • Multivariate Analysis
            • Oxidoreductases / blood
            • Phospholipases A / blood
            • Phospholipases A2
            • Prognosis
            • Respiration
            • Retrospective Studies

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            Citations

            This article has been cited 3 times.
            1. Blangy-Letheule A, Vergnaud A, Dupas T, Rozec B, Lauzier B, Leroux AA. Spontaneous Sepsis in Adult Horses: From Veterinary to Human Medicine Perspectives. Cells 2023 Mar 30;12(7).
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            2. Cummings CO, Krucik DDR, Price E. Clinical predictive models in equine medicine: A systematic review. Equine Vet J 2023 Jul;55(4):573-583.
              doi: 10.1111/evj.13880pubmed: 36199162google scholar: lookup
            3. Ihler CF, Venger JL, Skjerve E. Evaluation of clinical and laboratory variables as prognostic indicators in hospitalised gastrointestinal colic horses. Acta Vet Scand 2004;45(1-2):109-18.
              doi: 10.1186/1751-0147-45-109pubmed: 15535091google scholar: lookup
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