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Animals : an open access journal from MDPI2021; 11(9); doi: 10.3390/ani11092549

Data Collection for the Fourth Multicentre Confidential Enquiry into Perioperative Equine Fatalities (CEPEF4) Study: New Technology and Preliminary Results.

Abstract: It is almost 20 years since the largest observational, multicentre study evaluating the risks of mortality associated with general anaesthesia in horses. We proposed an internet-based method to collect data (cleaned and analysed with R) in a multicentre, cohort, observational, analytical, longitudinal and prospective study to evaluate peri-operative equine mortality. The objective was to report the usefulness of the method, illustrated with the preliminary data, including outcomes for horses seven days after undergoing general anaesthesia and certain procedures using standing sedation. Within six months, data from 6701 procedures under general anaesthesia and 1955 standing sedations from 69 centres were collected. The results showed (i) the utility of the method; also, that (ii) the overall mortality rate for general anaesthesia within the seven-day outcome period was 1.0%. In horses undergoing procedures other than exploratory laparotomy for colic ("noncolics"), the rate was lower, 0.6%, and in "colics" it was higher, at 3.4%. For standing sedations, the overall mortality rate was 0.2%. Finally, (iii) we present some descriptive data that demonstrate new developments since the previous CEPEF2. In conclusion, horses clearly still die unexpectedly when undergoing procedures under general anaesthesia or standing sedation. Our method is suitable for case collection for future studies.
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Publication Date: 2021-08-30 PubMed ID: 34573515PubMed Central: PMC8472153DOI: 10.3390/ani11092549Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper details an online data collection method for a study reviewing the risk of mortality in horses under general anesthesia. It presents preliminary findings from data encompassing around 6701 general anesthesia procedures and 1955 standing sedations, gathered over six months from 69 centers.

Objectives and Research Methodology

  • The research aims to assess the rate of per-operative equine mortality and to report the effectiveness of the newly proposed internet-based data collection method.
  • The data was gathered using digital means from centers across the globe which contributes to a multicenter, longitudinal, and prospective study.
  • The data was cleansed, standardized, and analyzed with R, a language and environment for statistical computing and graphics.

Data Collection and Preliminary Findings

  • In a period of six months, the researchers managed to collect data from various procedures, including 6701 general anesthesia and 1955 standing sedations from 69 centers around the world.
  • The preliminary results highlighted the utility of the online data collection method and served to illustrate the rates of mortality across different types of procedures.

Analysis and Results

  • The overall mortality rate for general anesthesia within the seven-day outcome period was found to be 1.0%.
  • For horses undergoing procedures other than exploratory laparotomy for colic, the mortality rate was lower at 0.6%.
  • On the other hand, the mortality rate was higher at 3.4% for horses undergoing laparotomy for colic.
  • In cases of standing sedations, the overall mortality rate was as low as 0.2%.

Conclusion

  • The research concludes that horses still face significant risks when undergoing procedures under general anesthesia or standing sedation. This implies an area that requires further research and improvements in medical procedures.
  • Furthermore, the research validates the use of the digital data collection method for future studies in similar fields.

Cite This Article

APA
Gozalo-Marcilla M, Bettschart-Wolfensberger R, Johnston M, Taylor PM, Redondo JI. (2021). Data Collection for the Fourth Multicentre Confidential Enquiry into Perioperative Equine Fatalities (CEPEF4) Study: New Technology and Preliminary Results. Animals (Basel), 11(9). https://doi.org/10.3390/ani11092549

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 11
Issue: 9

Researcher Affiliations

Gozalo-Marcilla, Miguel
  • Veterinary Clinical Sciences, The Royal (Dick) School of Veterinary Studies and The Roslin Institute, Easter Bush Campus, The University of Edinburgh, Edinburgh EH25 9RG, UK.
Bettschart-Wolfensberger, Regula
  • Department of Clinical Diagnostics and Services, Vetsuisse Faculty, University of Zürich, 8057 Zürich, Switzerland.
Johnston, Mark
  • Vetstream Ltd., Three Hills Farm, Bartlow, Cambridge CB21 EN, UK.
Taylor, Polly M
  • Taylor Monroe, Little Downham, Cambridge CB6 2TY, UK.
Redondo, Jose I
  • Departamento de Medicina y Cirugía Animal, Facultad de Veterinaria, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain.

Grant Funding

  • Kate Borer-Weir Fund / Association of Veterinary Anaesthetists

Conflict of Interest Statement

The authors declare no conflict of interest.

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