Demonstration of continuously seropositive population against Borna disease virus in Misaki feral horses, a Japanese strain: a four-year follow-up study from 1998 to 2001.
Abstract: Borna disease virus (BDV)-specific antibodies were monitored in Misaki feral horses annually for 4 years using an electrochemiluminescence immunoassay (ECLIA). Among 130 horses examined, 35 (26.9%) with an ECLIA count above 1000 once or more were judged as BDV seropositive. Throughout the study period, p24 antibodies were more frequent than p40 antibodies in almost all positive animals. Among the 35 seropositive horses, the ECLIA count was consistently high in 12 cases. Eleven horses seroconverted from negative to positive and 7 underwent reversal. The count in the remaining 95 horses (73.1%) remained low for 4 years and these animals were judged as seronegative.
Publication Date: 2002-06-19 PubMed ID: 12069079DOI: 10.1292/jvms.64.445Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research study aims to monitor the presence of Borna disease virus (BDV) specific antibodies in the Misaki feral horses, a Japanese strain, over a period of 4 years, using an instrument called electrochemiluminescence immunoassay (ECLIA). The results established a consistently seropositive population, with 26.9% being BDV seropositive and the presence of p24 antibodies being frequently dominant than the p40 antibodies.
Methodology
- The research was conducted through an annual inspection over a period of 4 years to monitor the BDV-specific antibodies in Misaki feral horses.
- The method of monitoring was through the usage of an electrochemiluminescence immunoassay (ECLIA).
- There were altogether 130 horses that were examined for both p24 and p40 antibodies.
Findings
- Out of the 130 horses studied, 35 horses (26.9%) showed an ECLIA count exceeding 1000 at least once or more during the study, which led them to be judged as BDV seropositive.
- The p24 antibodies were found to be more frequent than p40 antibodies in nearly all the BDV-positive horses. This indicates that p24 antibodies may be more significant in the immune response to the BDV among these horses.
- Among the seropositive horses, the ECLIA count was observed to be consistently high over the course of the study in 12 cases. This suggests a persistent immune response to the BDV in these animals.
- In the study, 11 horses showed seroconversion from negative to positive, indicating that these animals were likely newly infected during the study period.
- Furthermore, 7 horses showed a reversal, going from seropositive to seronegative. This could be indicative of the individual animal’s immune system defeating the virus or the limitations in the sensitivity of the diagnostic test.
- The remaining 95 horses accounted for 73.1% of the sample, and their ECLIA-counts remained low for the duration of the 4-year study, suggesting they were seronegative for BDV.
Conclusion
- The study concluded with the detection of a consistently seropositive population against BDV among Misaki feral horses over the span of 4 years.
- This research contributes to understanding the prevalence and dynamics of BDV infection in these specific horse populations and helps in planning effective disease management strategies.
Cite This Article
APA
Inoue Y, Yamaguchi K, Sawada T, Rivero JC, Horii Y.
(2002).
Demonstration of continuously seropositive population against Borna disease virus in Misaki feral horses, a Japanese strain: a four-year follow-up study from 1998 to 2001.
J Vet Med Sci, 64(5), 445-448.
https://doi.org/10.1292/jvms.64.445 Publication
Researcher Affiliations
- Department of Veterinary Teaching Hospital and Internal Medicine, Faculty of Agriculture, Miyazaki University, Gakuen-kibanadai, Japan.
MeSH Terms
- Aging
- Animals
- Antibodies, Viral / analysis
- Antibodies, Viral / blood
- Borna Disease / immunology
- Borna disease virus / immunology
- Electrochemistry / methods
- Female
- Horse Diseases / immunology
- Horse Diseases / virology
- Horses / classification
- Horses / immunology
- Horses / virology
- Immunoassay / methods
- Japan
- Luminescent Measurements
- Male
- Serologic Tests
- Time Factors
Citations
This article has been cited 4 times.- Barba M, Fairbanks EL, Daly JM. Equine viral encephalitis: prevalence, impact, and management strategies.. Vet Med (Auckl) 2019;10:99-110.
- Song JW, Na KS, Tae SH, Kim YK. Borna disease virus antibody and RNA from peripheral blood mononuclear cells of race horses and jockeys in Korea.. Psychiatry Investig 2011 Mar;8(1):58-60.
- Na KS, Tae SH, Song JW, Kim YK. Failure to detect borna disease virus antibody and RNA from peripheral blood mononuclear cells of psychiatric patients.. Psychiatry Investig 2009 Dec;6(4):306-12.
- Pisoni G, Nativi D, Bronzo V, Codazza D. Sero-epidemiological study of Borna disease virus infection in the Italian equine population.. Vet Res Commun 2007 Aug;31 Suppl 1:245-8.
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