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Home / Equine Research Bank / Vet J / Determination of ivermectin efficacy against cyathostomins a...
Veterinary journal (London, England : 1997)2010; 188(1); 44-47; doi: 10.1016/j.tvjl.2010.03.009

Determination of ivermectin efficacy against cyathostomins and Parascaris equorum on horse farms using selective therapy.

Abstract: Ivermectin resistance has recently been described in Parascaris equorum and there have been reports from several countries of a shortened egg reappearance period (ERP) following ivermectin treatment for cyathostomins. This study was aimed at determining the efficacy of ivermectin in treating cyathostomins and P. equorum in Danish horses. A total of 196 animals were selected from 52 farms, all of which were using a selective anthelmintic treatment strategy. ERP was investigated with weekly samples from 96 horses from nine farms. Horses were treated with ivermectin oral paste by their owners at an estimated dose rate of 0.2mg/kg. Overall, faecal egg counts were reduced 10-14 days after treatment by 96.9% and 100% for P. equorum and cyathostomins, respectively. Mean faecal egg count reductions at 4 and 6 weeks post treatment were 99.5% and 96.9%, respectively. No signs of developing ivermectin resistance were found in either cyathostomins or P. equorum in the studied horses.
Copyright © 2010 Elsevier Ltd. All rights reserved.
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Publication Date: 2010-04-10 PubMed ID: 20385508DOI: 10.1016/j.tvjl.2010.03.009Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article investigates how effective ivermectin medication is for treating two types of parasitic worms, cyathostomins and Parascaris equorum, in Danish horses. The study discovered that there were no signs of developing resistance to the medication in the worms of the horses studied.

Research Purpose

  • The main aim of this study was to determine the effectiveness of ivermectin, an anthelmintic (purchased by the horse’s owner), in treating two main types of gastrointestinal parasites, cyathostomins and Parascaris equorum which are common in horses.
  • The study was triggered by recent discoveries of ivermectin resistance in the latter and reports of a shorter egg reappearance period (ERP) post the ivermectin treatment in several countries for cyathostomins worms.

Study Methodology

  • A total of 196 horses were taken for the study from 52 farms, all of which were implementing a selective anthelmintic treatment strategy to control worm infections.
  • Every week, 96 horses from nine farms had samples taken for a stipulated period to observe the effect of the treatment.
  • All horses involved were treated using an ivermectin oral paste. The owners administered it at an estimated dose rate of 0.2mg/kg.

Research Findings

  • The research observed that the fecal egg counts of the parasites reduced by 96.9% for P. equorum and a solid 100% for cyathostomins between 10-14 days after the horses were treated with ivermectin.
  • By 4 and 6 weeks after the ivermectin treatment, mean faecal egg count reduced further, being 99.5% and 96.9%, respectively.
  • The important takeaway from the study is that no signs of developing ivermectin resistance were found for either cyathostomins or P. equorum in the sampled horses suggesting that the drug remains effective against these two types of parasites.

Cite This Article

APA
Larsen ML, Ritz C, Petersen SL, Nielsen MK. (2010). Determination of ivermectin efficacy against cyathostomins and Parascaris equorum on horse farms using selective therapy. Vet J, 188(1), 44-47. https://doi.org/10.1016/j.tvjl.2010.03.009

Publication

Veterinary journal (London, England : 1997)
ISSN: 1532-2971
NlmUniqueID: 9706281
Country: England
Language: English
Volume: 188
Issue: 1
Pages: 44-47

Researcher Affiliations

Larsen, Mette L
  • Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, DK-2630 Taastrup, Denmark.
Ritz, Christian
    Petersen, Stig L
      Nielsen, Martin K

        MeSH Terms

        • Animals
        • Anthelmintics / therapeutic use
        • Ascaridida Infections / drug therapy
        • Ascaridida Infections / veterinary
        • Ascaridoidea / drug effects
        • Ascaridoidea / growth & development
        • Drug Resistance
        • Female
        • Horse Diseases / drug therapy
        • Horse Diseases / parasitology
        • Horses
        • Ivermectin / therapeutic use
        • Male
        • Parasite Egg Count / veterinary
        • Strongylida Infections / drug therapy
        • Strongylida Infections / parasitology
        • Strongylida Infections / veterinary
        • Strongylus / drug effects
        • Strongylus / growth & development
        • Treatment Outcome

        Citations

        This article has been cited 11 times.
        1. Macdonald SL, Abbas G, Ghafar A, Gauci CG, Bauquier J, El-Hage C, Tennent-Brown B, Wilkes EJA, Beasley A, Jacobson C, Cudmore L, Carrigan P, Hurley J, Beveridge I, Hughes KJ, Nielsen MK, Jabbar A. Egg reappearance periods of anthelmintics against equine cyathostomins: The state of play revisited. Int J Parasitol Drugs Drug Resist 2023 Apr;21:28-39.
          doi: 10.1016/j.ijpddr.2022.12.002pubmed: 36543048google scholar: lookup
        2. Johnson ACB, Biddle AS. The Use of Molecular Profiling to Track Equine Reinfection Rates of Cyathostomin Species Following Anthelmintic Administration. Animals (Basel) 2021 May 9;11(5).
          doi: 10.3390/ani11051345pubmed: 34065099google scholar: lookup
        3. Papini RA, Orsetti C, Sgorbini M. A Controlled Study on Efficacy and Egg Reappearance Period of Ivermectin in Donkeys Naturally Infected with Small Strongyles. Helminthologia 2020 Jun 1;57(2):163-170.
          doi: 10.2478/helm-2020-0017pubmed: 32518493google scholar: lookup
        4. Sanna G, Pipia AP, Tamponi C, Manca R, Varcasia A, Traversa D, Scala A. Anthelmintics efficacy against intestinal strongyles in horses of Sardinia, Italy. Parasite Epidemiol Control 2016 Jun;1(2):15-19.
          doi: 10.1016/j.parepi.2016.01.001pubmed: 29988184google scholar: lookup
        5. Palomero AM, Hernández JA, Cazapal-Monteiro CF, Balán FA, Silva MI, Paz-Silva A, Sánchez-Andrade R, Vázquez MSA. Implementation of Biological Control to the Integrated Control of Strongyle Infection among Wild Captive Equids in a Zoological Park. Biomed Res Int 2018;2018:4267683.
          doi: 10.1155/2018/4267683pubmed: 29984232google scholar: lookup
        6. Misuno E, Clark CR, Anderson SL, Jenkins E, Wagner B, Dembek K, Petrie L. Characteristics of parasitic egg shedding over a 1-year period in foals and their dams in 2 farms in central Saskatchewan. Can Vet J 2018 Mar;59(3):284-292.
          pubmed: 29599559
        7. Molena RA, Peachey LE, Di Cesare A, Traversa D, Cantacessi C. Cyathostomine egg reappearance period following ivermectin treatment in a cohort of UK Thoroughbreds. Parasit Vectors 2018 Jan 25;11(1):61.
          doi: 10.1186/s13071-018-2638-6pubmed: 29370872google scholar: lookup
        8. Zak A, Siwinska N, Slowikowska M, Borowicz H, Kubiak K, Hildebrand J, Popiolek M, Niedzwiedz A. Searching for ivermectin resistance in a Strongylidae population of horses stabled in Poland. BMC Vet Res 2017 Jul 3;13(1):210.
          doi: 10.1186/s12917-017-1133-1pubmed: 28673347google scholar: lookup
        9. Matthews JB. Anthelmintic resistance in equine nematodes. Int J Parasitol Drugs Drug Resist 2014 Dec;4(3):310-5.
          doi: 10.1016/j.ijpddr.2014.10.003pubmed: 25516842google scholar: lookup
        10. Hamad MH, Islam SI, Jitsamai W, Chinkangsadarn T, Naraporn D, Ouisuwan S, Taweethavonsawat P. Patterns of Equine Small Strongyle Species Infection after Ivermectin Intervention in Thailand: Egg Reappearance Period and Nemabiome Metabarcoding Approach. Animals (Basel) 2024 Feb 8;14(4).
          doi: 10.3390/ani14040574pubmed: 38396542google scholar: lookup
        11. Nielsen MK. Anthelmintic resistance in equine nematodes: Current status and emerging trends. Int J Parasitol Drugs Drug Resist 2022 Dec;20:76-88.
          doi: 10.1016/j.ijpddr.2022.10.005pubmed: 36342004google scholar: lookup
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