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Russian agricultural sciences2020; 46(5); 530-533; doi: 10.3103/S1068367420050158

Developmental Results of a Vaccine against Salmonella-Induced Equine Abortion.

Abstract: An inactivated vaccine based on the BN-12 strain with the TNP-3 strain filtrate used as immunomodulator has been developed in order to prevent salmonella-induced equine abortion. Preclinical and clinical trials with the white mice and the horses, respectively, are carried out. The lack of toxicity is proven. The vaccine immunogenicity for mouse and mare models comprised 90 and 100%, respectively. The industrial vaccine tests showed that the industrial output of foals increased by 13.8% after immunization. Cost-effectiveness of the vaccine used with the TNP-3 strain filtrate comprised 14.1 rubles per 1 ruble of costs, which was 1.8-fold greater when compared to the vaccine used with a polyribonate medicine. It is ascertained that administration of the inactivated vaccine with the TNP-3 strain is an effective method to prevent infectious abortion. Scientific and technical documentation is developed based on the survey results in order to submit it for approval to the Federal Service for Veterinary and Phytosanitary Surveillance. The instruction is compliant with the approved use. The registration certificate (71-1-10.19-4495 no. PVR-1-1-.6/01631, as of June 10, 2019) has been issued.
© Allerton Press, Inc. 2020.
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Publication Date: 2020-11-04 PubMed ID: 33169058PubMed Central: PMC7641599DOI: 10.3103/S1068367420050158Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article discusses the development and testing of a vaccine to prevent salmonella-induced abortion in horses. The vaccine is found to be safe and effective in increasing foal production, providing better cost-effectiveness compared to another tested vaccine.

Development of the Vaccine

  • The researchers developed an inactive vaccine against salmonella-induced equine abortion. This vaccine was based on the BN-12 strain and incorporated the filtrate of the TNP-3 strain as an immunomodulator—a substance that helps enhance or suppress the immune response to a vaccine.

Trials and Test Results

  • The vaccine was tested in preclinical trials using white mice and clinical trials using horses. Through these tests, the researchers confirmed both the lack of toxicity and the vaccine’s high immunogenicity (ability to provoke an immune response) in both animal models.
  • The vaccine displayed a 90% immunogenicity rate in mice and a 100% rate in mares, indicating the vaccine was able to stimulate an immune response effectively in these animals, thus potentially protecting them from salmonella-induced abortion.

Industrial Application and Cost-Effectiveness

  • Upon testing the vaccine in an industrial setting, the researchers found that the number of foals produced increased by 13.8% after the mares were immunized.
  • The combined cost-effectiveness of creating the vaccine and its subsequent beneficial effects in the TNP-3 strain filtrate was 14.1 rubles per 1 ruble of costs. This ratio was 1.8 times higher than when compared to a vaccine used with a polyribonate medicine, indicating a better return on investment.

Approval

  • The researchers compiled scientific and technical documentation based on their results, showing that using the inactivated vaccine with the TNP-3 strain is effective in preventing infectious abortion caused by salmonella.
  • The research was submitted for approval to the Federal Service for Veterinary and Phytosanitary Surveillance, which subsequently granted a registration certificate for the vaccine.

Cite This Article

APA
Neustroev MP, Petrova SG. (2020). Developmental Results of a Vaccine against Salmonella-Induced Equine Abortion. Russ Agric Sci, 46(5), 530-533. https://doi.org/10.3103/S1068367420050158

Publication

Russian agricultural sciences
ISSN: 1068-3674
NlmUniqueID: 101574554
Country: United States
Language: English
Volume: 46
Issue: 5
Pages: 530-533

Researcher Affiliations

Neustroev, M P
  • Safronov Yakut Research Institute of Agriculture, 677001 Yakutsk, Sakha Republic Russia.
Petrova, S G
  • Safronov Yakut Research Institute of Agriculture, 677001 Yakutsk, Sakha Republic Russia.

Conflict of Interest Statement

Conflict of interest. The authors declare that they have no conflict of interest.

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This article includes 20 references
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Citations

This article has been cited 3 times.
  1. Wang Z, Zeng S, Wang Y, Wang T, Qu H, Zhu Y, Li J. Reproductive Disorders in Donkeys: Current Evidence and Update. Animals (Basel) 2024 Aug 28;14(17).
    doi: 10.3390/ani14172494pubmed: 39272279google scholar: lookup
  2. Li L, Li S, Ma H, Akhtar MF, Tan Y, Wang T, Liu W, Khan A, Khan MZ, Wang C. An Overview of Infectious and Non-Infectious Causes of Pregnancy Losses in Equine. Animals (Basel) 2024 Jul 2;14(13).
    doi: 10.3390/ani14131961pubmed: 38998073google scholar: lookup
  3. Guo K, Guo W, Liu D, Zhang W, Yang Y, Zhang Z, Li S, Wang J, Chu X, Wang Y, Hu Z, Wang X. Development and application of a competitive ELISA for the detection of antibodies against Salmonella Abortusequi in equids. J Clin Microbiol 2023 Nov 21;61(11):e0027323.
    doi: 10.1128/jcm.00273-23pubmed: 37874302google scholar: lookup
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