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Home / Equine Research Bank / Vet Clin North Am Equine Pract / Disorders of calcium and phosphate metabolism in horses.
The Veterinary clinics of North America. Equine practice2011; 27(1); 129-147; doi: 10.1016/j.cveq.2010.12.010

Disorders of calcium and phosphate metabolism in horses.

Abstract: Calcium and phosphate have structural and nonstructural functions, and their concentrations in the extracellular compartment are affected by the physiologic status of the animal as well as diseases. Important progress in understanding calcium and phosphorus metabolism in healthy and diseased horses and foals has been made in recent years. For example, several studies have confirmed that hypocalcemia is frequent in horses with gastrointestinal disease and that calcium endocrine dysregulation is associated with survival in foals. One critical point in the homeostasis of these minerals is their interaction and interdependence with other ions, including potassium and magnesium. In this review, the author provides a clinical overview on disorders of calcium and phosphate in the horse.
Copyright © 2011 Elsevier Inc. All rights reserved.
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Publication Date: 2011-03-12 PubMed ID: 21392658DOI: 10.1016/j.cveq.2010.12.010Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study discusses the factors affecting calcium and phosphate regulation in horses and recent discoveries concerning calcium and phosphorus metabolism in both healthy and unwell horses. The focus is set on their interaction with other significant ions, providing a clinical view on disorders of these essential elements.

Introduction

The research article begins by emphasizing the fundamental roles that calcium and phosphate play in the physiological functioning of horses. They carry out both structural (e.g., bone formation) and non-structural functions (e.g., cellular signaling). Their extracellular concentrations are influenced by various factors like the general physiological status of the animal and specific diseases.

Findings on Calcium and Phosphate Metabolism

  • The research paper elaborates on the significant advancements in the understanding of calcium and phosphorus metabolism in horses. These advancements have resulted from several studies conducted on both healthy and sick horses and foals.
  • A key finding noted is the frequent occurrence of hypocalcemia, or low calcium levels, in horses with gastrointestinal disease. This demonstrates the link and impact that certain diseases can have on calcium metabolism.

Role of Endocrine Dysregulation

  • Another critical observation from the studies was that endocrine regulation of calcium played a significant role in the survival rates of foals. Essentially, imbalances in the horse’s endocrine system, which regulates hormone distribution, can gravely affect calcium levels and subsequently the health and survival of young horses.

Interactions with Other Ions

  • The research also examines the interactions between calcium and phosphate with other ions. This interdependence is considered key to the homeostasis (stable equilibrium) of these minerals in the horse’s body. The ions mentioned specifically in this regard include potassium and magnesium, implying that any metabolic disturbances of these could impact calcium and phosphorus metabolism.

Clinical Overview

The author concludes the research article by providing a clinical overview of disorders related to calcium and phosphate in horses. This provides an important practical angle, linking the underlying biochemistry and metabolism to observable clinical manifestations.

Cite This Article

APA
Toribio RE. (2011). Disorders of calcium and phosphate metabolism in horses. Vet Clin North Am Equine Pract, 27(1), 129-147. https://doi.org/10.1016/j.cveq.2010.12.010

Publication

The Veterinary clinics of North America. Equine practice
ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 27
Issue: 1
Pages: 129-147

Researcher Affiliations

Toribio, Ramiro E
  • Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon Tharp Street, Columbus, OH 43210, USA. toribio.1@osu.edu

MeSH Terms

  • Animals
  • Animals, Newborn
  • Calcium / administration & dosage
  • Calcium / deficiency
  • Calcium / metabolism
  • Female
  • Homeostasis / physiology
  • Horse Diseases / metabolism
  • Horses
  • Male
  • Nutritional Requirements
  • Phosphates / administration & dosage
  • Phosphates / deficiency
  • Phosphates / metabolism

Citations

This article has been cited 18 times.
  1. Dosi MCM, Riggs CM, May J, Lee A, Cillan-Garcia E, Pagan J, McGorum BC. Thoroughbred Racehorses in Hong Kong Require Vitamin D Supplementation to Mitigate the Risk of Low Vitamin D Status. Animals (Basel) 2023 Jun 29;13(13).
    doi: 10.3390/ani13132145pubmed: 37443942google scholar: lookup
  2. Li W, Wang J, Wang Y, Guan R, Zhao F, Zhang R. Additional hemoperfusion for patients receiving maintenance hemodialysis: a retrospective analysis. Am J Transl Res 2023;15(6):4045-4054.
    pubmed: 37434811
  3. Drozdzewska K, Gehlen H. Markers for internal neoplasia in the horse. Vet Med Sci 2023 Jan;9(1):132-143.
    doi: 10.1002/vms3.1042pubmed: 36495211google scholar: lookup
  4. Sponseller BT, Wong DM, Ruby R, Ware WA, Wilson S, Haynes JS. Systemic calcinosis in a Quarter Horse gelding homozygous for a myosin heavy chain 1 mutation. J Vet Intern Med 2022 Jul;36(4):1543-1549.
    doi: 10.1111/jvim.16481pubmed: 35801821google scholar: lookup
  5. Sanmartí J, Armengou L, Troya-Portillo L, Robles-Guirado JÁ, Bassols A, Ríos J, Jose-Cunilleras E. Plasma-Ionized Magnesium in Hospitalized Horses with Gastrointestinal Disorders and Systemic Inflammatory Response Syndrome. Animals (Basel) 2022 Jun 7;12(12).
    doi: 10.3390/ani12121479pubmed: 35739816google scholar: lookup
  6. Sykes CA, Uzal FA, Mete A, Ochoa J, Filigenzi M, Poppenga RH, Asin J. Renal Lesions in Horses with Oleander (Nerium oleander) Poisoning. Animals (Basel) 2022 Jun 3;12(11).
    doi: 10.3390/ani12111443pubmed: 35681907google scholar: lookup
  7. Farrell A, Kersh K, Liepman R, Dembek KA. Development of a Colic Scoring System to Predict Outcome in Horses. Front Vet Sci 2021;8:697589.
    doi: 10.3389/fvets.2021.697589pubmed: 34692803google scholar: lookup
  8. Schumacher SA, Kamr AM, Lakritz J, Burns TA, Bertone AL, Toribio RE. Effects of intravenous magnesium sulfate on serum calcium-regulating hormones and plasma and urinary electrolytes in healthy horses. PLoS One 2021;16(6):e0247542.
    doi: 10.1371/journal.pone.0247542pubmed: 34181644google scholar: lookup
  9. Asin J, Murphy BG, Samol MA, Polanco J, Moore JD, Uzal FA. Rickets in a Thoroughbred-cross foal: case report and review of the literature. J Vet Diagn Invest 2021 Sep;33(5):987-992.
    doi: 10.1177/10406387211025232pubmed: 34160312google scholar: lookup
  10. Corley KTT. Metabolic disorders in foals. Equine Vet Educ 2012 Aug;24(8):392-395.
    doi: 10.1111/j.2042-3292.2011.00376.xpubmed: 32313388google scholar: lookup
  11. Fradinho MJ, Mateus L, Bernardes N, Bessa RJB, Caldeira RM, Ferreira-Dias G. Growth patterns, metabolic indicators and osteoarticular status in the Lusitano horse: A longitudinal study. PLoS One 2019;14(7):e0219900.
    doi: 10.1371/journal.pone.0219900pubmed: 31314780google scholar: lookup
  12. Kamr AM, Dembek KA, Reed SM, Slovis NM, Zaghawa AA, Rosol TJ, Toribio RE. Vitamin D Metabolites and Their Association with Calcium, Phosphorus, and PTH Concentrations, Severity of Illness, and Mortality in Hospitalized Equine Neonates. PLoS One 2015;10(6):e0127684.
    doi: 10.1371/journal.pone.0127684pubmed: 26046642google scholar: lookup
  13. Duaso J, Perez-Ecija A, Navarro A, Martínez E, De Las Heras A, Mendoza FJ. Evaluation of Blood Biochemical Parameters and Ratios in Piroplasmosis-Infected Horses in an Endemic Region. Vet Sci 2025 Jul 5;12(7).
    doi: 10.3390/vetsci12070643pubmed: 40711303google scholar: lookup
  14. Conrad MB, Leatherwood JL, Paris BL, George JM, Martinez RE, Vergara-Hernandez FB, Nielsen BD, Colbath AC, Arnold CE, Glass KG, Welsh TH Jr, Bradbery AN. Effects of clodronate disodium on endocrine regulators of calcium in yearling horses. J Anim Sci 2025 Jan 4;103.
    doi: 10.1093/jas/skaf132pubmed: 40259552google scholar: lookup
  15. Kamr AM, Bartish C, Summers J, Horton J, Hostnik LD, Orr K, Browne N, Dembek KA, Saliba C, Gomez DE, Toribio RE. Longitudinal Evaluation of Vitamin D, Parathyroid Hormone, Antimicrobial Peptides, and Immunomodulatory Genes in Hospitalized Foals. J Vet Intern Med 2025 Mar-Apr;39(2):e70012.
    doi: 10.1111/jvim.70012pubmed: 40008921google scholar: lookup
  16. Monteiro LC, Costa CM, Ermita PAN, Júnior SJPG, Mattos FS, Mansur FC, Dos Santos MO, Alves SR, Mafort EG, Fidélis CF, Avanza MFB, Teixeira RBC, Viana RB, Filho JDR. Treatment of experimental hyperchloremic metabolic acidosis in horses with enteral electrolyte solution containing sodium acetate. Front Vet Sci 2024;11:1376578.
    doi: 10.3389/fvets.2024.1376578pubmed: 39323875google scholar: lookup
  17. Giraldo AF, Carballo R, Serrenho RC, Tran V, Valverde A, Renaud DL, Gomez DE. Association of the type of metabolic acidosis and non-survival of horses with colitis. Can Vet J 2023 Nov;64(11):1044-1050.
    pubmed: 37915775
  18. Flood J, Byrne D, Bauquier J, Agne GF, Wise JC, Medina-Torres CE, Wood K, Sullivan O, Stewart AJ. Right dorsal colitis in horses: A multicenter retrospective study of 35 cases. J Vet Intern Med 2023 Nov-Dec;37(6):2535-2543.
    doi: 10.1111/jvim.16884pubmed: 37800408google scholar: lookup
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