Distribution of substance P-like immunoreactivity in the enteric neurons of the large colon of normal and amitraz-treated ponies: an immunocytochemical study.
Abstract: The distribution of the putative motor excitatory neurotransmitter, substance P, was studied immunocytochemically in the left dorsal colon of four normal control ponies and three ponies with amitraz-induced impaction colic. Substance P-like immunoreactivity in the control ponies was observed in nerve fibres in all layers of the bowel wall and in the nerve cell bodies of the enteric ganglia. The substance P-like immunoreactivity was clearly more intense in the cell bodies of submucosal ganglia than in those of the myenteric ganglia. The internodal nerve strands of the myenteric plexus were very rich in substance P-like immunoreactivity and within the ganglia they formed dense varicose networks around the neuronal cell bodies. Nerve bundles rich in substance P-like immunoreactivity diverged inward from the myenteric plexus to contribute an abundance of varicose immunoreactive fibres to the circular muscle of the tunica muscularis. Nerve fascicles with substance P-like immunoreactivity were sparse in the longitudinal muscle except in the thickened taenial band. In the submucosa many of the nerve fibres with substance P-like immunoreactivity appeared to arise from ganglionic cell bodies. Immunoreactive fibres commonly condensed around arterial vessels in the submucosa. Fine immunoreactive nerve fascicles from the submucosal plexus also projected internally to supply the muscularis mucosae and form periglandular arrays in the lamina propria. The distribution of substance P-like immunoreactivity in the normal equine colon differed in some respects from patterns observed in large intestines of other mammals. When the colons of normal and amitraz-treated ponies were compared no differences were discerned in the distribution or intensity of substance P-like reactivity.
Publication Date: 1985-01-01 PubMed ID: 2579808DOI: 10.1111/j.2042-3306.1985.tb02032.xGoogle Scholar: Lookup
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- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research examines the distribution of a neurotransmitter called substance P in the large colon of normal ponies and those suffering from impaction colic triggered by amitraz. No changes in distribution or intensity of substance P were noticed when the colons of normal and amitraz-treated ponies were compared.
Substance P and its Role
- The study focuses on the neurotransmitter, substance P, which is believed to stimulate motor activity.
- It was observed in nerve fibres spread across all layers of bowel wall and nerve cell bodies in the enteric ganglia of a pony’s left dorsal colon.
- The substance P was noticeably more present in the cell bodies of the submucosal ganglia as compared to the myenteric ganglia.
Observations in Normal Ponies
- In normal ponies, internodal nerve strands of the myenteric plexus had an abundance of substance P.
- These strands formed networks around the neuronal cell bodies inside the ganglia.
- Nerve bundles rich in the substance diverged from the myenteric plexus towards the circular muscle of the tunica muscularis.
- However, in the longitudinal muscle, the presence of substance P was sparse, barring the thickened taenial band.
- In the submucosa, nerve fibres with substance P appeared to originate from ganglionic cell bodies.
- These immunoreactive fibres often condensed around arterial vessels in the submucosa.
- Fine nerve fascicles with substance P from the submucosal plexus also projected towards the muscularis mucosae and surrounded gland structures in the lamina propria.
Comparative Analysis
- Contact of substance P in the colon of a normal horse differs in some way from patterns found in large intestines of other mammals.
- There were no substantial differences in the distribution pattern or intensity of substance P reactivity when the colons of normal and amitraz-treated ponies were compared.
Cite This Article
APA
Cummings JF, Sellers AF, Lowe JE.
(1985).
Distribution of substance P-like immunoreactivity in the enteric neurons of the large colon of normal and amitraz-treated ponies: an immunocytochemical study.
Equine Vet J, 17(1), 23-29.
https://doi.org/10.1111/j.2042-3306.1985.tb02032.x Publication
Researcher Affiliations
MeSH Terms
- Animals
- Colon / drug effects
- Colon / immunology
- Colon / metabolism
- Histocytochemistry
- Horses / immunology
- Insecticides / pharmacology
- Neurons / drug effects
- Neurons / immunology
- Neurons / metabolism
- Substance P / immunology
- Substance P / metabolism
- Toluidines / pharmacology
Citations
This article has been cited 2 times.- Hudson NP, Pearson GT, Mayhew IG. Tissue culture of the enteric nervous system from equine ileum.. Vet Res Commun 2000 Jul;24(5):299-307.
- Pearson GT. Structural organization and neuropeptide distributions in the equine enteric nervous system: an immunohistochemical study using whole-mount preparations from the small intestine.. Cell Tissue Res 1994 Jun;276(3):523-34.
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