DNA vaccines–back in the saddle again?
Abstract: A promising new horse vaccine may reignite enthusiasm for DNA vaccine technology in designing prophylactics against infectious disease. Kendall Powell reports.
Publication Date: 2004-07-02 PubMed ID: 15229530PubMed Central: PMC7097118DOI: 10.1038/nbt0704-799Google Scholar: Lookup
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Summary
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The research article discusses the potential revival of DNA vaccine technology for the prevention of infectious diseases, supported by the success of a new horse vaccine.
Introduction
- The article begins by setting the context for the overall discussion, indicating that DNA vaccine technology might be getting a new lease on life due to the development of a promising new horse vaccine.
The Relevance of DNA Vaccines
- DNA vaccines have been under the scientific spotlight due to their potential applications in combating a range of infectious diseases.
- Despite initial interest, progress in this field has been slow due to various technical challenges and the limited success in clinical trials.
The New Horse Vaccine
- The new horse vaccine, as reported by the article, appears to be a successful application of DNA vaccine technology.
- This could rekindle enthusiasm within the scientific community in further exploring the potential uses of DNA vaccines.
Implication
- The success of the new horse vaccine might trigger a renewed research focus in the field of DNA vaccine technology.
- This might herald a new era of breakthroughs in designing prophylactics against a range of infectious diseases.
Conclusion
- The article concludes on a note of cautious optimism hoping that the success of the horse vaccine can be replicated in future DNA vaccine research pursuits.
Cite This Article
APA
Powell K.
(2004).
DNA vaccines–back in the saddle again?
Nat Biotechnol, 22(7), 799-801.
https://doi.org/10.1038/nbt0704-799 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Cancer Vaccines / therapeutic use
- Horse Diseases / prevention & control
- Horse Diseases / virology
- Horses
- Humans
- Vaccines, DNA / therapeutic use
- Viral Vaccines / therapeutic use
- West Nile Fever / prevention & control
- West Nile Fever / veterinary
- West Nile virus / immunology
References
This article includes 7 references
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Citations
This article has been cited 11 times.- Morse MA, Gwin WR 3rd, Mitchell DA. Vaccine Therapies for Cancer: Then and Now. Target Oncol 2021 Mar;16(2):121-152.
- Afrough B, Dowall S, Hewson R. Emerging viruses and current strategies for vaccine intervention. Clin Exp Immunol 2019 May;196(2):157-166.
- Jeong H, Seong BL. Exploiting virus-like particles as innovative vaccines against emerging viral infections. J Microbiol 2017 Mar;55(3):220-230.
- Dalmia N, Klimstra WB, Mason C, Ramsay AJ. DNA-Launched Alphavirus Replicons Encoding a Fusion of Mycobacterial Antigens Acr and Ag85B Are Immunogenic and Protective in a Murine Model of TB Infection. PLoS One 2015;10(8):e0136635.
- García-Sastre A, Mena I. Novel vaccine strategies against emerging viruses. Curr Opin Virol 2013 Apr;3(2):210-6.
- Starodubova ES, Isaguliants MG, Karpov VL. Regulation of Immunogen Processing: Signal Sequences and Their Application for the New Generation of DNA-Vaccines. Acta Naturae 2010 Apr;2(1):53-60.
- Movsesyan N, Davtyan H, Mkrtichyan M, Petrushina I, Tiraturyan T, Ross T, Agadjanyan MG, Ghochikyan A, Cribbs DH. Low concentrations of anti-Aβ antibodies generated in Tg2576 mice by DNA epitope vaccine fused with 3C3d molecular adjuvant do not affect AD pathology. Hum Gene Ther 2010 Nov;21(11):1569-76.
- Tang M, Wang H, Zhou S, Tian G. Enhancement of the immunogenicity of an infectious bronchitis virus DNA vaccine by a bicistronic plasmid encoding nucleocapsid protein and interleukin-2. J Virol Methods 2008 Apr;149(1):42-8.
- Mealey RH, Stone DM, Hines MT, Alperin DC, Littke MH, Leib SR, Leach SE, Hines SA. Experimental Rhodococcus equi and equine infectious anemia virus DNA vaccination in adult and neonatal horses: effect of IL-12, dose, and route. Vaccine 2007 Oct 23;25(43):7582-97.
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- Derrick SC, Yang AL, Morris SL. Vaccination with a Sindbis virus-based DNA vaccine expressing antigen 85B induces protective immunity against Mycobacterium tuberculosis. Infect Immun 2005 Nov;73(11):7727-35.
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