Double blind investigation of the effects of oral supplementation of combined glucosamine hydrochloride (GHCL) and chondroitin sulphate (CS) on stride characteristics of veteran horses.

This research investigates the effects of a combined glucosamine hydrochloride (GHCL) and chondroitin sulphate (CS) supplement on the stride and joint mobility of old, athletic or arthritic horses. The findings demonstrated improvements in stride characteristics of treated horses, suggesting these supplements may contribute to better welfare by reducing symptoms of degenerative joint disease.

Methodology

• Twenty veteran horses were divided into two group – a treatment group (15 horses) and a placebo group (5 horses).
• The team initially recorded pre-treatment gait characteristics at a trot using digital video footage.
• Joint motion range, stride length, and swing and stance duration were evaluated using 2-dimensional motion analysis.
• The horses were given treatment (or placebo) daily for 12 weeks based on the recommended dosage by the manufacturer.
• Gait reassessment was conducted every four weeks following the same protocol as pre-treatment.
• A double-blind procedure, where both the researchers and the subjects did not know who received the treatment or placebo, was carried out to prevent bias.
• Relationships between variables were analysed using a General Linear Model.

Results

• Statistically significant differences were noted in treated horses by the 8th week of evaluation.
• The range of joint motion showed notable increase in the elbow, stifle, and hind fetlock.
• Stride length significantly improved with the treatment.
• An increased swing duration was noted by the 12th week, with the stance duration remaining constant.

Conclusions

• The research concluded that oral GHCL and CS supplement offered symptoms relief to old horses, which was demonstrated through improved stride characteristics.
• Based on the findings, the study suggests that GHCL and CS supplementation may enhance the welfare of the horses by alleviating symptoms of degenerative joint disease.