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Journal of veterinary pharmacology and therapeutics2008; 31(5); 466-471; doi: 10.1111/j.1365-2885.2008.00978.x

Drug contamination of the equine racetrack environment: a preliminary examination.

Abstract: Advances in analytical technology now make it feasible to detect and confirm exceptionally low concentrations (pg to fg/mL) of drugs and their metabolites in equine biological fluids. These new capabilities complicate the regulatory interpretation of drug positives and bring into question the fair application of medication rules. Such approaches and policies are further complicated by the possibility that drug positives may arise from contamination of the equine environment on the backstretch of the race track. This manuscript provides data demonstrating that the general environment of the backstretch in which horses live is contaminated with therapeutic drugs and drugs of human origin. The major contaminants are nonsteroidal anti-inflammatory drugs, such as flunixin, phenylbutazone and naproxen, present in the soil in stalls, on stall surfaces, in the dust that circulates and in the lagoon waters that accumulate on the backstretch. The presence of caffeine and cotinine suggest other possible vectors for contamination by humans. Concentrations of these compounds as well as their frequency of occurrence are provided.
Publication Date: 2008-11-13 PubMed ID: 19000266DOI: 10.1111/j.1365-2885.2008.00978.xGoogle Scholar: Lookup
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  • Journal Article

Summary

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This research study investigated the contamination of equine racetracks with therapeutic drugs and human-originated substances, proposing that this may lead to false-positive drug tests for racehorses.

Context and Objectives of the Study

  • The study was motivated by the advances in analytical technology that can detect very low concentrations of drugs and their metabolites in equine biological fluids.
  • While these new capabilities enhance the accuracy of drug testing, they also complicate the regulatory interpretation of ‘positive’ results as they may be tied to drug contamination of the equine environment rather than actual drug use by the horses.
  • The main objective of this study was to examine the presence of drug contaminants in the equine racetrack environment and raise questions regarding the validity of drug tests and the fair application of medication rules.

Contamination Examination and Main Findings

  • The researchers provided data that signified the presence of drug contaminants in the general environment of the equine racetrack backstretch.
  • They found that the major contaminants are nonsteroidal anti-inflammatory drugs (NSAIDs) like flunixin, phenylbutazone, and naproxen. These were detected in stall soils, on stall surfaces, in circulating dust, and lagoon waters at the backstretch.
  • In addition to these drugs, they also discovered the presence of caffeine and cotinine, signaling potential human contamination.
  • The study provides specific concentrations and frequency of occurrence of these compounds in the investigated environments.

Implications of the Study

  • This research brings attention to the need for reconsideration of medication rules and regulations in the context of horseracing.
  • The possible environmental contamination may lead to false-positive results in drug tests which can mislead the regulatory authorities and impact the fairness of decisions regarding equine athletes.

Cite This Article

APA
Barker SA. (2008). Drug contamination of the equine racetrack environment: a preliminary examination. J Vet Pharmacol Ther, 31(5), 466-471. https://doi.org/10.1111/j.1365-2885.2008.00978.x

Publication

ISSN: 1365-2885
NlmUniqueID: 7910920
Country: England
Language: English
Volume: 31
Issue: 5
Pages: 466-471

Researcher Affiliations

Barker, S A
  • Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA. sbarker@vetmed.lsu.edu

MeSH Terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / analysis
  • Caffeine / analysis
  • Clonixin / analogs & derivatives
  • Clonixin / analysis
  • Dust / analysis
  • Environmental Pollutants / analysis
  • Fresh Water / analysis
  • Gas Chromatography-Mass Spectrometry
  • Horses
  • Housing, Animal
  • Naproxen / analysis
  • Pharmaceutical Preparations / analysis
  • Phenylbutazone / analysis
  • Soil / analysis

Citations

This article has been cited 1 times.
  1. Hairgrove TB, Mask JW, Mays TP, Fajt VR, Bentke AL, Warner JL, Baynes RE. Detection of flunixin in the urine of untreated pigs housed with pigs treated with flunixin meglumine at labeled doses. Transl Anim Sci 2019 Jul;3(4):1399-1404.
    doi: 10.1093/tas/txz099pubmed: 32704903google scholar: lookup