Early embryonic death in equines and camelids.
Abstract: This paper includes the study of early embryonic death (EED), predisposing factors of EED and treatment. EED refers to the fetal mortality which varies in mare and camelids but most probably not later than 50 days of gestation. This duration may be divided into very early mortality, early mortality and late embryonic mortality. This also varies in mare and camelids. There are different embryonic, maternal, environmental/external, and infectious and noninfectious factors which lead to early embryonic loss. Diagnosis is very difficult as in most of the cases resorption of fetus occurs but it is done by the use of ultrasound. Unfortunately, there is no treatment to avoid early embryonic mortality. However, new reproductive technologies have increased the service rate in a herd, and efforts are still being made to determine the rate and frequency of camel embryonic loss.
Publication Date: 2022-12-01 PubMed ID: 36777062PubMed Central: PMC9805778DOI: 10.5455/OVJ.2022.v12.i6.16Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Review
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article explores early embryonic death (EED) in both equines and camelids, focusing on the factors leading to EED and potential treatments.
About EED
- The research addresses early embryonic death (EED), a term for fetal death that generally happens within 50 days of gestation for both mares and camelids.
- EED period can be divided into three categories: very early mortality, early mortality, and late embryonic mortality. The precise period for each category varies between mares and camelids.
Factors leading to EED
- Researchers identified multiple aspects that might induce EED. These factors are generally divided into four categories: embryonic, maternal, environmental/external, and infectious and noninfectious.
- The embryonic factors pertain to the condition and development of the embryo itself, while maternal factors concern the mother’s health condition.
- Environmental or external factors involve surrounding conditions like ambient temperature, pollution, and diet which can affect pregnancy.
- Infectious and noninfectious factors consist of diseases or disorders either from an outside source (infectious) or within the mother’s body (noninfectious).
Diagnosis and treatment for EED
- Diagnosing EED is challenging as the fetus is often reabsorbed into the body. Ultrasound is the primary method used to detect the condition.
- Regrettably, no definitive treatment or preventive measure for EED has yet been discovered according to the research.
Advancements and future research
- New reproductive technologies have helped increase pregnancy rates in herds, which is a promising development.
- However, there is an ongoing need to understand the rate and frequency of embryonic loss in camels, highlighting a key area for future research.
Cite This Article
APA
Ashraf R, Rashid S, Rasheed I, Asif S.
(2022).
Early embryonic death in equines and camelids.
Open Vet J, 12(6), 903-909.
https://doi.org/10.5455/OVJ.2022.v12.i6.16 Publication
Researcher Affiliations
- Faculty of Veterinary Sciences, University of Agriculture, Faisalabad, Pakistan.
- Faculty of Veterinary Sciences, University of Agriculture, Faisalabad, Pakistan.
- Faculty of Veterinary Sciences, University of Agriculture, Faisalabad, Pakistan.
- Faculty of Veterinary Sciences, University of Agriculture, Faisalabad, Pakistan.
MeSH Terms
- Animals
- Female
- Horses
- Camelidae
- Abortion, Veterinary
References
This article includes 82 references
- Ababneh MM, Troedsson MH, Michelson JR, Seguin BE. Partial characterization of an equine conceptus prostaglandin inhibitory factor.. J Reprod Fertil Suppl 2000;(56):607-13.
- Abdelnour SA, Yang CY, Swelum AA, Abd El-Hack ME, Khafaga AF, Abdo M, Shang JH, Lu YQ. Molecular, functional, and cellular alterations of oocytes and cumulus cells induced by heat stress and shock in animals.. Environ Sci Pollut Res Int 2020 Nov;27(31):38472-38490.
- Abdoon AS, Giraud-Delville C, Kandil OM, Kerboeuf-Giraud A, Eozénou C, Carvalho AV, Julian S, Sandra O. Maternal recognition of pregnancy and implantation are not associated with an interferon response of the endometrium to the presence of the conceptus in dromedary camel.. Theriogenology 2017 Mar 1;90:301-308.
- Abo-Aziza F.A., Ashry H.M., Nassar S.A.. Haematological and biochemical alterations in subclinically affected dromedary camels with Trypanosoma evansi during breeding season in Egypt. J. Chem. Pharma. Sci. 2017;10(3):1326–1334.
- Al Khalifa I., Alshaikh M.A., Aljumaah R.S., Jarelnabi A., Hussein M.F.. Serological prevalence of abortifacient agents in female Mijaheem camels (Camelus dromedarius) in Saudi Arabia. Anim. Res. 2018;8(3):335–343.
- Ali A, Baby B, Vijayan R. From Desert to Medicine: A Review of Camel Genomics and Therapeutic Products.. Front Genet 2019;10:17.
- Ali A, Derar D, Alsharari A, Alsharari A, Khalil R, Almundarij TI, Alboti Y, Al-Sobayil F. Factors affecting reproductive performance in dromedary camel herds in Saudi Arabia.. Trop Anim Health Prod 2018 Jun;50(5):1155-1160.
- Allen WR. Luteal deficiency and embryo mortality in the mare.. Reprod Domest Anim 2001 Aug;36(3-4):121-31.
- Allen WR, Wilsher S. A review of implantation and early placentation in the mare.. Placenta 2009 Dec;30(12):1005-15.
- Al-Suhaimi E.A., Khan F.A.. The pituitary gland: functional relationship with the hypothalamus, structure, and physiology. In Emerging concepts in endocrine structure and functions. Singapore, Springer: 2022.
- Ball BA, Little TV, Hillman RB, Woods GL. Pregnancy rates at Days 2 and 14 and estimated embryonic loss rates prior to day 14 in normal and subfertile mares.. Theriogenology 1986 Nov;26(5):611-9.
- Barnea E.R.. Signaling between embryo and mother in early pregnancy: basis for development of tolerance. In: Recurrent pregnancy loss— causes, controversies, and treatment. 2014. pp. 17–28.
- Bergfelt DR, Woods JA, Ginther OJ. Role of the embryonic vesicle and progesterone in embryonic loss in mares.. J Reprod Fertil 1992 Jul;95(2):339-47.
- Beyer T, Rink BE, Scarlet D, Walter I, Kunert S, Aurich C. Early luteal phase progestin concentration influences endometrial function in pregnant mares.. Theriogenology 2019 Feb;125:236-241.
- Brinsko SP, Ball BA, Ellington JE. In vitro maturation of equine oocytes obtained from different age groups of sexually mature mares.. Theriogenology 1995 Sep;44(4):461-9.
- Brinsko SP, Ball BA, Miller PG, Thomas PG, Ellington JE. In vitro development of day 2 embryos obtained from young, fertile mares and aged, subfertile mares.. J Reprod Fertil 1994 Nov;102(2):371-8.
- Butler WR, Smith RD. Interrelationships between energy balance and postpartum reproductive function in dairy cattle.. J Dairy Sci 1989 Mar;72(3):767-83.
- Canisso IF, Segabinazzi LGTM, Fedorka CE. Persistent Breeding-Induced Endometritis in Mares - a Multifaceted Challenge: From Clinical Aspects to Immunopathogenesis and Pathobiology.. Int J Mol Sci 2020 Feb 20;21(4).
- Carnevale E.M., Bergfelt D.R., Ginther O.J.. Follicular activity and concentrations of FSH and LH associated with senescence in mares. Anim. Reprod. Sci. 1994;35(3–4):231–246.
- Carnevale E.M., Ginther O.J.. Defective oocytes as a cause of subfertility in old mares. Biol. Reprod. 1995;52:209–214.
- Daels PF, Stabenfeldt GH, Hughes JP, Odensvik K, Kindahl H. Effects of flunixin meglumine on endotoxin-induced prostaglandin F2 alpha secretion during early pregnancy in mares.. Am J Vet Res 1991 Feb;52(2):276-81.
- Darwish WS, Ikenaka Y, Nakayama SM, Ishizuka M. An overview on mycotoxin contamination of foods in Africa.. J Vet Med Sci 2014 Jun;76(6):789-97.
- Dholpuria S, Vyas S, Purohit GN, Pathak KM. Sonographic monitoring of early follicle growth induced by melatonin implants in camels and the subsequent fertility.. J Ultrasound 2012 Jun;15(2):135-41.
- Di Renzo GC, Giardina I, Clerici G, Brillo E, Gerli S. Progesterone in normal and pathological pregnancy.. Horm Mol Biol Clin Investig 2016 Jul 1;27(1):35-48.
- Donovan C., Brunsden S., Purdy S.R.. Ovarian, uterine, and embryonic dynamics in early pregnancy in Alpacas. In: ICAR 2012 Satellite Meeting on Camelid Reproduction. 2012. p. 78.
- Dubey JP. Recent advances in Neospora and neosporosis.. Vet Parasitol 1999 Aug 1;84(3-4):349-67.
- Fernandes CB, Ball BA, Loux SC, Boakari YL, Scoggin KE, El-Sheikh Ali H, Cogliati B, Esteller-Vico A. Uterine cervix as a fundamental part of the pathogenesis of pregnancy loss associated with ascending placentitis in mares.. Theriogenology 2020 Mar 15;145:167-175.
- Fowler M.. Medicine and surgery of camelids. Hoboken, NJ: John Wiley and Sons; 2011.
- Foxcroft GR. Mechanisms mediating nutritional effects on embryonic survival in pigs.. J Reprod Fertil Suppl 1997;52:47-61.
- Gherissi D.E., Bouzebda Z., Afri F.B., Lamraoui R., Chacha F.. Cross-sectional survey of congenital and acquired genital disorders in sahraoui female camels (Camelus dromedarius) at El Oued abattoir, south-east Algeria. Anim. Res. Int. 2019;16(3):3450–3462.
- Graham TW, Giri SN, Daels PF, Cullor JS, Keen CL, Thurmond MC, Dellinger JD, Stabenfeldt GH, Osburn BI. Associations among prostaglandin F2alpha, plasma zinc, copper and iron concentrations and fetal loss in cows and mares.. Theriogenology 1995 Aug;44(3):379-90.
- Griffin PG, Ginther OJ. Research applications of ultrasonic imaging in reproductive biology.. J Anim Sci 1992 Mar;70(3):953-72.
- Gupta U., Solanki H.. Boron: impact on seed germination and growth of Solanum melongena L. plant nutrient relation. LAP LAMBERT Academic Publishing; 2012.
- Hogan J.P., Phillips C.J.C.. Starvation of ruminant livestock. Anim. Nutr. 2016;16:29–57.
- Jarrar B., Faye B.. Normal pattern of camel histology. Riyadh, Saudi Arabia: FAO publications; 2013.
- Jauchem JR. Exposure to extremely-low-frequency electromagnetic fields and radiofrequency radiation: cardiovascular effects in humans.. Int Arch Occup Environ Health 1997;70(1):9-21.
- Kallings P. Nonsteroidal anti-inflammatory drugs.. Vet Clin North Am Equine Pract 1993 Dec;9(3):523-41.
- Khalafalla AI, Al Eknah MM, Abdelaziz M, Ghoneim IM. A study on some reproductive disorders in dromedary camel herds in Saudi Arabia with special references to uterine infections and abortion.. Trop Anim Health Prod 2017 Jun;49(5):967-974.
- Khan B.B., Arshad I., Riaz M.. Production and management of camels. Faisalabad, Pakistan: University of Agriculture; 2003.
- King S.S., Nequin L.G., Alexander T., Drake S., Griffin R., Hebner T.. Alterations in the equine estrous cycle following estradiol or antiestradiol administration. J. Equine Vet. Sci. 1990;10(3):198–203.
- Krakowski L, Krawczyk CH, Wrona Z, Dabrowski R, Jarosz Ł. Levels of selected T lymphocyte subpopulations in peripheral blood of mares which experienced early embryonic death.. Anim Reprod Sci 2010 Jul;120(1-4):71-7.
- Lefebvre RC. Fetal mummification in the major domestic species: current perspectives on causes and management.. Vet Med (Auckl) 2015;6:233-244.
- Lesser MP, Kruse VA. Seasonal temperature compensation in the horse mussel, Modiolus modiolus: metabolic enzymes, oxidative stress and heat shock proteins.. Comp Biochem Physiol A Mol Integr Physiol 2004 Mar;137(3):495-504.
- Letaief N., Bedhiaf-Romdhani S.. Camel herd management under pastoral system in southern of Tunisia. In: Addressing the challenges of agro-pastoral farming systems. Options mediterraneennes, series A. 2022. p. 129.
- MacKay E., VanHoy G., Lakritz J.. Old world camelids. Med. Sur. Cam. 2022;3:621–643.
- Mann GE, Fray MD, Lamming GE. Effects of time of progesterone supplementation on embryo development and interferon-tau production in the cow.. Vet J 2006 May;171(3):500-3.
- Mann GE, Lamming GE. Relationship between maternal endocrine environment, early embryo development and inhibition of the luteolytic mechanism in cows.. Reproduction 2001 Jan;121(1):175-80.
- McDowell K.J., Williams N.M., Donahue J.M., Poole L., Barney W.E., Coe B., Deborde S., Ennis L., Newman K.E., Lindemann M.. Deductive investigations of the role of eastern tent caterpillars in mare reproductive loss syndrome. In: Proceeding workshop on the equine placenta. 2003. pp. 99–102.
- Meyer AE, Pfeiffer CA, Brooks KE, Spate LD, Benne JA, Cecil R, Samuel MS, Murphy CN, Behura S, McLean MK, Ciernia LA, Smith MF, Whitworth KM, Wells KD, Spencer TE, Prather RS, Geisert RD. New perspective on conceptus estrogens in maternal recognition and pregnancy establishment in the pig†.. Biol Reprod 2019 Jul 1;101(1):148-161.
- Nagel C, Aurich C, Aurich J. Stress effects on the regulation of parturition in different domestic animal species.. Anim Reprod Sci 2019 Aug;207:153-161.
- Nagy P, Reiczigel J, Gupta AD, Barua R, Juhász J. Pregnancy and parturition in dromedary camels II. Incidence, timing and factors affecting early pregnancy loss (EPL) and the outcome of twin pregnancies.. Theriogenology 2021 Sep 15;172:289-299.
- Padalino B.. Effects of the different transport phases on equine health status, behavior, and welfare: a review. J. Vet. Behav. 2015;10(3):272–282.
- Padalino B., Monaco D., Lacalandra G.M.. Male camel behavior and breeding management strategies: how to handle a camel bull during the breeding season. Emir. J. Food. Agri. 2015;27(4):338–349.
- Pearson L.K., Rodriguez J.S., Tibary A.. Disorders and diseases of pregnancy. Llama. Alpaca. Care. 2014;37:256.
- Perry G.A., Smith M.F.. Management factors that impact the efficiency of applied reproductive technologies. In: Proceeding IEEE. 2015. pp. 208–232.
- Pratap N., Manjunatha B.M., Al Bulushi S.. Incidence of early pregnancy loss in dromedary camels (Camelus dromedarius). In: Proceeding of the Third Conference of International Society of Camelid Research and Development. 2012. pp. 109–110.
- Qazi IH, Angel C, Yang H, Pan B, Zoidis E, Zeng CJ, Han H, Zhou GB. Selenium, Selenoproteins, and Female Reproduction: A Review.. Molecules 2018 Nov 22;23(12).
- Radostits O.M., Gay C., Hinchcliff K.W., Constable P.D.. Veterinary medicine e-book: a textbook of the diseases of cattle, horses, sheep, pigs and goats. Else. Health. Sci. 2006;10:177–183.
- Robinson RS, Fray MD, Wathes DC, Lamming GE, Mann GE. In vivo expression of interferon tau mRNA by the embryonic trophoblast and uterine concentrations of interferon tau protein during early pregnancy in the cow.. Mol Reprod Dev 2006 Apr;73(4):470-4.
- Rose BV, Firth M, Morris B, Roach JM, Wathes DC, Verheyen KLP, de Mestre AM. Descriptive study of current therapeutic practices, clinical reproductive findings and incidence of pregnancy loss in intensively managed thoroughbred mares.. Anim Reprod Sci 2018 Jan;188:74-84.
- Runcan E.E., da Silva M.A.C.. Reproduction and the reproductive system. Med. Surg. Camelids. 2022;3:423–480.
- Satué K., Gardon J.C.. Pregnancy loss in Mares. In: Genital Infections and Infertility. 2016. pp. 329–354.
- Schjenken JE, Robertson SA. The Female Response to Seminal Fluid.. Physiol Rev 2020 Jul 1;100(3):1077-1117.
- Scoggin CF. Not just a number: effect of age on fertility, pregnancy and offspring vigour in thoroughbred brood-mares.. Reprod Fertil Dev 2015 Jul;27(6):872-9.
- Sharp DC, Thatcher MJ, Salute ME, Fuchs AR. Relationship between endometrial oxytocin receptors and oxytocin-induced prostaglandin F2 alpha release during the oestrous cycle and early pregnancy in pony mares.. J Reprod Fertil 1997 Jan;109(1):137-44.
- Silver M. Placental progestagens in the sheep and horse and the changes leading to parturition.. Exp Clin Endocrinol 1994;102(3):203-11.
- Snider TA. Reproductive Disorders in Horses.. Vet Clin North Am Equine Pract 2015 Aug;31(2):389-405.
- Spencer P.. Nomads in alliance: symbiosis and growth among the Rendille and Samburu of Kenya. Oxford, UK: Oxford University Press; 2012.
- Thorburn GD. A speculative review of parturition in the mare.. Equine Vet J Suppl 1993 Apr;(14):41-9.
- Tibary A, Anouassi A. Retrospective study on an unusual form of ovario-bursal pathology in the camel (Camelus dromedarius).. Theriogenology 2001 Aug 1;56(3):415-24.
- Tibary A, Fite C, Anouassi A, Sghiri A. Infectious causes of reproductive loss in camelids.. Theriogenology 2006 Aug;66(3):633-47.
- Torner H, Alm H, Kanitz W, Goellnitz K, Becker F, Poehland R, Bruessow KP, Tuchscherer A. Effect of initial cumulus morphology on meiotic dynamic and status of mitochondria in horse oocytes during IVM.. Reprod Domest Anim 2007 Apr;42(2):176-83.
- Vaala WE, Sertich PL. Management strategies for mares at risk for periparturient complications.. Vet Clin North Am Equine Pract 1994 Apr;10(1):237-65.
- Vanderwall D.K.. Early embryonic loss in the mare. J. Equine. Vet. Sci. 2008;28(11):691–702.
- Vettical BS, Hong SB, Umer MA, Wani NA. Comparison of pregnancy rates with transfer of in vivo produced embryos derived using multiple ovulation and embryo transfer (MOET) with in vitro produced embryos by somatic cell nuclear transfer (SCNT) in the dromedary camel (Camelus dromedaries).. Anim Reprod Sci 2019 Oct;209:106132.
- Volkmann D, Zent W, Little T, Riddle T, Durenberger J, Potenza K, Sibley L, Roser J. Hormone profiles of mares affected by the mare reproductive loss syndrome.. Reprod Domest Anim 2008 Oct;43(5):578-83.
- Weaver L.T., Prentice A.. Nutrition in infancy. In: Nutrition in Early Life. 2003. pp. 205–232.
- Willmann C, Schuler G, Hoffmann B, Parvizi N, Aurich C. Effects of age and altrenogest treatment on conceptus development and secretion of LH, progesterone and eCG in early-pregnant mares.. Theriogenology 2011 Feb;75(3):421-8.
- Wilmut I, Sales DI, Ashworth CJ. Maternal and embryonic factors associated with prenatal loss in mammals.. J Reprod Fertil 1986 Mar;76(2):851-64.
- Woods J, Bergfelt DR, Ginther OJ. Effects of time of insemination relative to ovulation on pregnancy rate and embryonic-loss rate in mares.. Equine Vet J 1990 Nov;22(6):410-5.
- Yagil R.. The desert camel. Comparative physiological adaptation. Karger. 1985.
- Zama AM, Uzumcu M. Epigenetic effects of endocrine-disrupting chemicals on female reproduction: an ovarian perspective.. Front Neuroendocrinol 2010 Oct;31(4):420-39.
Citations
This article has been cited 0 times.Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists