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The Veterinary clinics of North America. Equine practice2023; 39(1); 99-113; doi: 10.1016/j.cveq.2022.11.007

Eastern, Western, and Venezuelan Equine Encephalitis and West Nile Viruses: Clinical and Public Health Considerations.

Abstract: The continued recognition and emergence of alphavirus and flavivirus diseases is a growing veterinary and public health concern. As the global environment continues to change, mosquito-borne diseases will continue to evolve and expand. Continued development of readily available vaccines for the prevention of these diseases in humans and animals is essential to controlling epizootics of these diseases. Further research into effective antiviral treatments is also sorely needed. This article describes equine encephalitis viruses with a focus on clinical and public health considerations.
Publication Date: 2023-02-01 PubMed ID: 36737290DOI: 10.1016/j.cveq.2022.11.007Google Scholar: Lookup
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Summary

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The research article discusses the increasing concern of alphavirus and flavivirus diseases in animals and humans, due to changing global conditions. It emphasizes the need for more readily available vaccines and effective antiviral treatments, focusing on equine encephalitis viruses from a clinical and public health standpoint.

Research Background

  • The research broadly concerns itself with the emerging threats of alphavirus and flavivirus diseases, particularly in the backdrop of a swiftly changing global environment.
  • These diseases are transmitted by mosquitoes and will continue to progress as the habitat and behavior of mosquitoes change with climate and habitat changes.
  • The authors underscore the double-edged sword of this situation as it impacts both veterinary medicine and public health.

Equine Encephalitis Viruses

  • The study provides a deep dive into equine encephalitis viruses, that are spread to horses and humans by infected mosquitoes.
  • Three types of horse brain inflammation (encephalitis) caused by viruses are discussed: Eastern, Western, and Venezuelan equine encephalitis.
  • The study also presents clinical considerations for these, discussing the potential symptoms, diagnosis methods, and treatment options.

Vaccines and Treatments

  • The paper signifies the importance of developing readily available vaccines to prevent these diseases in humans and animals, focusing on the need for locating and controlling these epidemics.
  • Moreover, it also highlights the necessity for further research into effective antiviral treatments.
  • The goal is to develop treatments that can not only cure these diseases but also prevent them from spreading and causing large-scale health crises.

Public Health Considerations

  • A critical aspect of the study focuses on public health considerations – contemplating how these diseases, if unchecked, could impact human populations around the world.
  • Such diseases pose significant challenges for public health systems, both in terms of prevention and treatment.
  • It thus emphasizes the importance of a comprehensive public health strategy to address such emerging threats effectively.

Cite This Article

APA
Luethy D. (2023). Eastern, Western, and Venezuelan Equine Encephalitis and West Nile Viruses: Clinical and Public Health Considerations. Vet Clin North Am Equine Pract, 39(1), 99-113. https://doi.org/10.1016/j.cveq.2022.11.007

Publication

ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 39
Issue: 1
Pages: 99-113
PII: S0749-0739(22)00071-2

Researcher Affiliations

Luethy, Daniela
  • Large Animal Internal Medicine, Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, PO Box 100136, Gainesville, FL 32610, USA. Electronic address: dluethy@ufl.edu.

MeSH Terms

  • Animals
  • Horses
  • Humans
  • West Nile virus
  • Encephalomyelitis, Venezuelan Equine / veterinary
  • Public Health
  • Horse Diseases
  • Alphavirus

Citations

This article has been cited 6 times.
  1. Irekeola AA, Alshehri AA. Human West Nile virus infection: a meta-analysis of recent global data (2019-24). J Glob Health 2025 Oct 17;15:04278.
    doi: 10.7189/jogh.15.04278pubmed: 41105829google scholar: lookup
  2. Yin L, VanderGiessen M, Kumar V, Conacher B, Chao PH, Theus M, Johnson E, Kehn-Hall K, Wu X, Xie H. Machine learning identifies genes linked to neurological disorders induced by equine encephalitis viruses, traumatic brain injuries, and organophosphorus nerve agents. Front Comput Neurosci 2025;19:1529902.
    doi: 10.3389/fncom.2025.1529902pubmed: 40433315google scholar: lookup
  3. Aranda-Coello JM, Machain-Williams C, Weber M, Dzul Rosado AR, Simpkins TR, Blitvich BJ. Serologic Surveillance for Orthoflaviviruses and Chikungunya Virus in Bats and Opossums in Chiapas, Mexico. Viruses 2025 Apr 22;17(5).
    doi: 10.3390/v17050590pubmed: 40431603google scholar: lookup
  4. Padda H, Huang CY, Grimm K, Biggerstaff BJ, Ledermann JP, Raetz J, Boroughs K, Mossel EC, Martin SW, Lehman JA, Townsend RL, Krysztof D, Saá P, Dinh ETN, Stobierski MG, Esponda-Morrison B, Wolujewicz KAA, Osborne M, Brown CM, Hopkins B, Schiffman EK, Garvin A, Lee X, Osborn RA, Wozniak RJ, Brault AC, Basavaraju SV, Stramer SL, Staples JE, Gould CV. Powassan and Eastern Equine Encephalitis Virus Seroprevalence in Endemic Areas, United States, 2019-2020. Emerg Infect Dis 2025 May;31(5):929-936.
    doi: 10.3201/eid3105.240893pubmed: 40305306google scholar: lookup
  5. VanderGiessen M, de Jager C, Leighton J, Xie H, Theus M, Johnson E, Kehn-Hall K. Neurological manifestations of encephalitic alphaviruses, traumatic brain injuries, and organophosphorus nerve agent exposure. Front Neurosci 2024;18:1514940.
    doi: 10.3389/fnins.2024.1514940pubmed: 39734493google scholar: lookup
  6. Thannickal SA, Spector SN, Stapleford KA. The La Crosse virus class II fusion glycoprotein ij loop contributes to infectivity and replication in vitro and in vivo. J Virol 2023 Aug 31;97(8):e0081923.
    doi: 10.1128/jvi.00819-23pubmed: 37578236google scholar: lookup