FREE SHIPPING over $40
OVER 10000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Current topics in microbiology and immunology2012; 359; 11-23; doi: 10.1007/82_2012_214

Ecological aspects of hendra virus.

Abstract: Hendra virus, a novel and fatally zoonotic member of the family Paramyxoviridae, was first described in Australia in 1994. Periodic spillover from its natural host (fruit bats) results in catastrophic disease in horses and occasionally the subsequent infection of humans. Prior to 2011, 14 equine incidents involving seven human cases (four fatal) were recorded. The year 2011 saw a dramatic departure from the sporadic incidents of the previous 16 years, with a cluster of 18 incidents in a single 3-month period. The fundamental difference in 2011 was the total number of incidents, the geographic clustering, and the expanded geographic range. The 2011 cluster more than doubled the total number of incidents previously reported, and poses the possibility of a new HeV infection paradigm. Epidemiologic evidence suggests that compelling additional host and/or environmental factors were at play.
Get Full Text
Publication Date: 2012-04-06 PubMed ID: 22476530DOI: 10.1007/82_2012_214Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article
  • Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article presents a study on Hendra virus, a lethal zoonotic virus first discovered in Australia in 1994. It mainly identifies the potential changes in the patterns of HeV infection based on an increased number of recorded incidents in 2011 as compared to the previous years.

Hendra Virus

  • The study covers the Hendra virus (HeV), a deadly zoonotic virus belonging to the Paramyxoviridae family. It was first identified in 1994 in Australia.
  • HeV commonly affects fruit bats, its natural host, but sporadically spills over to horses, causing severe disease. Occasionally, humans get infected from the infected horses.

Historical Incident Data

  • Prior to 2011, there had been 14 equine incidents which led to seven human cases, out of which four were fatal.

The 2011 Cluster

  • In 2011, there was a significant increase in the occurrence of HeV incidents, with 18 incidents observed within three months. This dramatic surge was unusual compared to the sporadic incidents recorded in the preceding 16 years.
  • Notable differences during this year included the total number of incidents, geographic clustering, and the expansion of the geographic range.
  • This surge doubled the total number of HeV incidents previously reported, suggesting a possible new pattern of HeV infections.

Epidemiology and Other Factors

  • The researchers hypothesize that other host or environmental factors may have been involved, as suggested by the epidemiological evidence.
  • The study does not mention what these factors could be, implying that further research is needed to identify and understand these additional factors and their role in the spread of HeV.

Cite This Article

APA
Field H, Crameri G, Kung NY, Wang LF. (2012). Ecological aspects of hendra virus. Curr Top Microbiol Immunol, 359, 11-23. https://doi.org/10.1007/82_2012_214

Publication

Current topics in microbiology and immunology
ISSN: 0070-217X
NlmUniqueID: 0110513
Country: Germany
Language: English
Volume: 359
Pages: 11-23

Researcher Affiliations

Field, Hume
  • Biosecurity Queensland, Department of Employment, Economic Development and Innovation, Brisbane, QLD, Australia. hume.field@qld.gov.au
Crameri, Gary
    Kung, Nina Yu-Hsin
      Wang, Lin-Fa

        MeSH Terms

        • Animals
        • Australia / epidemiology
        • Chiroptera / virology
        • Disease Outbreaks
        • Ecosystem
        • Hendra Virus / isolation & purification
        • Hendra Virus / pathogenicity
        • Henipavirus Infections / epidemiology
        • Henipavirus Infections / veterinary
        • Henipavirus Infections / virology
        • Horse Diseases / epidemiology
        • Horse Diseases / virology
        • Horses / virology
        • Humans
        • Phylogeography
        • Zoonoses / epidemiology
        • Zoonoses / virology

        Citations

        This article has been cited 30 times.
        1. Epstein JH, Anthony SJ, Islam A, Kilpatrick AM, Ali Khan S, Balkey MD, Ross N, Smith I, Zambrana-Torrelio C, Tao Y, Islam A, Quan PL, Olival KJ, Khan MSU, Gurley ES, Hossein MJ, Field HE, Fielder MD, Briese T, Rahman M, Broder CC, Crameri G, Wang LF, Luby SP, Lipkin WI, Daszak P. Nipah virus dynamics in bats and implications for spillover to humans. Proc Natl Acad Sci U S A 2020 Nov 17;117(46):29190-29201.
          doi: 10.1073/pnas.2000429117pubmed: 33139552google scholar: lookup
        2. Edson D, Peel AJ, Huth L, Mayer DG, Vidgen ME, McMichael L, Broos A, Melville D, Kristoffersen J, de Jong C, McLaughlin A, Field HE. Time of year, age class and body condition predict Hendra virus infection in Australian black flying foxes (Pteropus alecto). Epidemiol Infect 2019 Jan;147:e240.
          doi: 10.1017/S0950268819001237pubmed: 31364577google scholar: lookup
        3. Dawes BE, Freiberg AN. Henipavirus infection of the central nervous system. Pathog Dis 2019 Mar 1;77(2).
          doi: 10.1093/femspd/ftz023pubmed: 30985897google scholar: lookup
        4. Johnson RI, Tachedjian M, Rowe B, Clayton BA, Layton R, Bergfeld J, Wang LF, Marsh GA. Alston Virus, a Novel Paramyxovirus Isolated from Bats Causes Upper Respiratory Tract Infection in Experimentally Challenged Ferrets. Viruses 2018 Nov 28;10(12).
          doi: 10.3390/v10120675pubmed: 30487438google scholar: lookup
        5. Saha N, Robev D, Mason EO, Himanen JP, Nikolov DB. Therapeutic potential of targeting the Eph/ephrin signaling complex. Int J Biochem Cell Biol 2018 Dec;105:123-133.
          doi: 10.1016/j.biocel.2018.10.006pubmed: 30343150google scholar: lookup
        6. Mwangi W, de Figueiredo P, Criscitiello MF. One Health: Addressing Global Challenges at the Nexus of Human, Animal, and Environmental Health. PLoS Pathog 2016 Sep;12(9):e1005731.
          doi: 10.1371/journal.ppat.1005731pubmed: 27631500google scholar: lookup
        7. Pickering BS, Hardham JM, Smith G, Weingartl ET, Dominowski PJ, Foss DL, Mwangi D, Broder CC, Roth JA, Weingartl HM. Protection against henipaviruses in swine requires both, cell-mediated and humoral immune response. Vaccine 2016 Sep 14;34(40):4777-86.
          doi: 10.1016/j.vaccine.2016.08.028pubmed: 27544586google scholar: lookup
        8. Plowright RK, Peel AJ, Streicker DG, Gilbert AT, McCallum H, Wood J, Baker ML, Restif O. Transmission or Within-Host Dynamics Driving Pulses of Zoonotic Viruses in Reservoir-Host Populations. PLoS Negl Trop Dis 2016 Aug;10(8):e0004796.
          doi: 10.1371/journal.pntd.0004796pubmed: 27489944google scholar: lookup
        9. Smith CS, McLAUGHLIN A, Field HE, Edson D, Mayer D, Ossedryver S, Barrett J, Waltisbuhl D. Twenty years of Hendra virus: laboratory submission trends and risk factors for infection in horses. Epidemiol Infect 2016 Nov;144(15):3176-3183.
          doi: 10.1017/S0950268816001400pubmed: 27357144google scholar: lookup
        10. Burroughs AL, Durr PA, Boyd V, Graham K, White JR, Todd S, Barr J, Smith I, Baverstock G, Meers J, Crameri G, Wang LF. Hendra Virus Infection Dynamics in the Grey-Headed Flying Fox (Pteropus poliocephalus) at the Southern-Most Extent of Its Range: Further Evidence This Species Does Not Readily Transmit the Virus to Horses. PLoS One 2016;11(6):e0155252.
          doi: 10.1371/journal.pone.0155252pubmed: 27304985google scholar: lookup
        11. Broder CC, Weir DL, Reid PA. Hendra virus and Nipah virus animal vaccines. Vaccine 2016 Jun 24;34(30):3525-34.
          doi: 10.1016/j.vaccine.2016.03.075pubmed: 27154393google scholar: lookup
        12. McMichael L, Edson D, Mayer D, McLaughlin A, Goldspink L, Vidgen ME, Kopp S, Meers J, Field H. Temporal Variation in Physiological Biomarkers in Black Flying-Foxes (Pteropus alecto), Australia. Ecohealth 2016 Mar;13(1):49-59.
          doi: 10.1007/s10393-016-1113-0pubmed: 27026357google scholar: lookup
        13. Degeling C, Johnson J, Kerridge I, Wilson A, Ward M, Stewart C, Gilbert G. Implementing a One Health approach to emerging infectious disease: reflections on the socio-political, ethical and legal dimensions. BMC Public Health 2015 Dec 29;15:1307.
          doi: 10.1186/s12889-015-2617-1pubmed: 26715066google scholar: lookup
        14. Field H, Jordan D, Edson D, Morris S, Melville D, Parry-Jones K, Broos A, Divljan A, McMichael L, Davis R, Kung N, Kirkland P, Smith C. Spatiotemporal Aspects of Hendra Virus Infection in Pteropid Bats (Flying-Foxes) in Eastern Australia. PLoS One 2015;10(12):e0144055.
          doi: 10.1371/journal.pone.0144055pubmed: 26625128google scholar: lookup
        15. Dietrich M, Mühldorfer K, Tortosa P, Markotter W. Leptospira and Bats: Story of an Emerging Friendship. PLoS Pathog 2015;11(11):e1005176.
          doi: 10.1371/journal.ppat.1005176pubmed: 26562435google scholar: lookup
        16. Edson D, Field H, McMichael L, Vidgen M, Goldspink L, Broos A, Melville D, Kristoffersen J, de Jong C, McLaughlin A, Davis R, Kung N, Jordan D, Kirkland P, Smith C. Routes of Hendra Virus Excretion in Naturally-Infected Flying-Foxes: Implications for Viral Transmission and Spillover Risk. PLoS One 2015;10(10):e0140670.
          doi: 10.1371/journal.pone.0140670pubmed: 26469523google scholar: lookup
        17. Field HE, Smith CS, de Jong CE, Melville D, Broos A, Kung N, Thompson J, Dechmann DK. Landscape Utilisation, Animal Behaviour and Hendra Virus Risk. Ecohealth 2016 Mar;13(1):26-38.
          doi: 10.1007/s10393-015-1066-8pubmed: 26403793google scholar: lookup
        18. Edson D, Field H, McMichael L, Jordan D, Kung N, Mayer D, Smith C. Flying-fox roost disturbance and Hendra virus spillover risk. PLoS One 2015;10(5):e0125881.
          doi: 10.1371/journal.pone.0125881pubmed: 26016629google scholar: lookup
        19. El Najjar F, Lampe L, Baker ML, Wang LF, Dutch RE. Analysis of cathepsin and furin proteolytic enzymes involved in viral fusion protein activation in cells of the bat reservoir host. PLoS One 2015;10(2):e0115736.
          doi: 10.1371/journal.pone.0115736pubmed: 25706132google scholar: lookup
        20. Plowright RK, Eby P, Hudson PJ, Smith IL, Westcott D, Bryden WL, Middleton D, Reid PA, McFarlane RA, Martin G, Tabor GM, Skerratt LF, Anderson DL, Crameri G, Quammen D, Jordan D, Freeman P, Wang LF, Epstein JH, Marsh GA, Kung NY, McCallum H. Ecological dynamics of emerging bat virus spillover. Proc Biol Sci 2015 Jan 7;282(1798):20142124.
          doi: 10.1098/rspb.2014.2124pubmed: 25392474google scholar: lookup
        21. Yun T, Park A, Hill TE, Pernet O, Beaty SM, Juelich TL, Smith JK, Zhang L, Wang YE, Vigant F, Gao J, Wu P, Lee B, Freiberg AN. Efficient reverse genetics reveals genetic determinants of budding and fusogenic differences between Nipah and Hendra viruses and enables real-time monitoring of viral spread in small animal models of henipavirus infection. J Virol 2015 Jan 15;89(2):1242-53.
          doi: 10.1128/JVI.02583-14pubmed: 25392218google scholar: lookup
        22. Smith C, Skelly C, Kung N, Roberts B, Field H. Flying-fox species density--a spatial risk factor for Hendra virus infection in horses in eastern Australia. PLoS One 2014;9(6):e99965.
          doi: 10.1371/journal.pone.0099965pubmed: 24936789google scholar: lookup
        23. Cox-Witton K, Reiss A, Woods R, Grillo V, Baker RT, Blyde DJ, Boardman W, Cutter S, Lacasse C, McCracken H, Pyne M, Smith I, Vitali S, Vogelnest L, Wedd D, Phillips M, Bunn C, Post L. Emerging infectious diseases in free-ranging wildlife-Australian zoo based wildlife hospitals contribute to national surveillance. PLoS One 2014;9(5):e95127.
          doi: 10.1371/journal.pone.0095127pubmed: 24787430google scholar: lookup
        24. Middleton D, Pallister J, Klein R, Feng YR, Haining J, Arkinstall R, Frazer L, Huang JA, Edwards N, Wareing M, Elhay M, Hashmi Z, Bingham J, Yamada M, Johnson D, White J, Foord A, Heine HG, Marsh GA, Broder CC, Wang LF. Hendra virus vaccine, a one health approach to protecting horse, human, and environmental health. Emerg Infect Dis 2014 Mar;20(3):372-9.
          doi: 10.3201/eid2003.131159pubmed: 24572697google scholar: lookup
        25. Sawford K, Dhand NK, Toribio JA, Taylor MR. The use of a modified Delphi approach to engage stakeholders in zoonotic disease research priority setting. BMC Public Health 2014 Feb 20;14:182.
          doi: 10.1186/1471-2458-14-182pubmed: 24552445google scholar: lookup
        26. Mire CE, Geisbert JB, Agans KN, Feng YR, Fenton KA, Bossart KN, Yan L, Chan YP, Broder CC, Geisbert TW. A recombinant Hendra virus G glycoprotein subunit vaccine protects nonhuman primates against Hendra virus challenge. J Virol 2014 May;88(9):4624-31.
          doi: 10.1128/JVI.00005-14pubmed: 24522928google scholar: lookup
        27. Baker KS, Suu-Ire R, Barr J, Hayman DT, Broder CC, Horton DL, Durrant C, Murcia PR, Cunningham AA, Wood JL. Viral antibody dynamics in a chiropteran host. J Anim Ecol 2014 Mar;83(2):415-28.
          doi: 10.1111/1365-2656.12153pubmed: 24111634google scholar: lookup
        28. Shi Z. Emerging infectious diseases associated with bat viruses. Sci China Life Sci 2013 Aug;56(8):678-82.
          doi: 10.1007/s11427-013-4517-xpubmed: 23917838google scholar: lookup
        29. Breed AC, Meers J, Sendow I, Bossart KN, Barr JA, Smith I, Wacharapluesadee S, Wang L, Field HE. The distribution of henipaviruses in Southeast Asia and Australasia: is Wallace's line a barrier to Nipah virus?. PLoS One 2013;8(4):e61316.
          doi: 10.1371/journal.pone.0061316pubmed: 23637812google scholar: lookup
        30. Degeling C, Kerridge I. Hendra in the news: public policy meets public morality in times of zoonotic uncertainty. Soc Sci Med 2013 Apr;82:156-63.
          doi: 10.1016/j.socscimed.2012.12.024pubmed: 23294874google scholar: lookup
        Subscribe to our newsletter
        Join 99,727 horse owners like you who receive our email updates on horse health and nutrition.