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Home / Equine Research Bank / Vet Rec / Effect of a combination of butorphanol and detomidine on end...
The Veterinary record2022; 190(9); e1483; doi: 10.1002/vetr.1483

Effect of a combination of butorphanol and detomidine on endoscopic assessment of laryngeal function in Thoroughbred yearlings.

Abstract: To the authors' knowledge, the effect of a combination of butorphanol tartrate and detomidine hydrochloride on the laryngeal function and symmetry of the arytenoid cartilages in young Thoroughbred horses has not been examined. Therefore, this study aimed to examine the effects of administration of butorphanol and detomidine on left-to-right rima glottidis ratio (L:R RGR), cross-sectional area of the rima glottidis (CSARG) and grade of laryngeal function of Thoroughbred yearlings examined endoscopically at rest. Forty-six Thoroughbred yearlings underwent laryngeal video endoscopy, at rest, before and after sedation with butorphanol and detomidine. Three clinicians assigned grades of laryngeal function after reviewing the video recordings. The L:R RGR and CSARG were measured at the point of arytenoid cartilages' maximal abduction. Student's t-test was used to compare the L:R RGR and CSARG. Cohen's kappa (κ) was used to compare the intra- and interobserver agreements. Spearman's rank order was used to assess agreement between CSARG and grade of laryngeal function. Sedation had no effect on L:R RGR and CSARG. Mean intraobserver agreement of grade of laryngeal function of unsedated yearlings was 93.1%, and that of sedated yearlings was 92.9%. Mean interobserver agreement of grade of laryngeal function of unsedated yearlings was 92.8%, and that of sedated yearlings was 92.7%. Correlation between CSARG and laryngeal function grade was significant for both groups (p < 0.001). Sedating Thoroughbred yearlings with detomidine and butorphanol, before endoscopically examining the larynx, did not significantly affect the grade of laryngeal function.
© 2022 British Veterinary Association.
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Publication Date: 2022-03-29 PubMed ID: 35352348DOI: 10.1002/vetr.1483Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research studied the effects of two drugs, butorphanol and detomidine, on laryngeal function in young thoroughbred horses. The findings indicated no significant change in measurements related to laryngeal function and grading after sedation using these drugs.

Objective of the Research

  • The main objective of this research study was to understand the impacts of a combination of two drugs, butorphanol tartrate and detomidine hydrochloride, on the laryngeal function and symmetry of the arytenoid cartilages in young Thoroughbred horses.
  • An additional goal was to evaluate the impact of these drugs on left-to-right rima glottidis ratio (L:R RGR), cross-sectional area of the rima glottidis (CSARG) and the grade of laryngeal function.

Research Procedure

  • A total of 46 Thoroughbred yearlings were part of this experiment. Laryngeal video endoscopy was carried out before and after sedation with the drugs butorphanol and detomidine.
  • Three clinicians reviewed the recorded video footage and graded laryngeal function post-sedation. The L:R RGR and the CSARG were measured to further assess arytenoid cartilages’ function.
  • Different statistical tests such as Cohen’s kappa (κ), Student’s t-test and Spearman’s rank order were used to analyze and compare the L:R RGR, CSARG, intra- and interobserver agreements, and the correlation between CSARG and the laryngeal function grade.

Research Findings

  • The results revealed that sedation did not have an impact on either the L:R RGR or the CSARG.
  • The intraobserver agreement was quite stable with 93.1% for unsedated yearlings and 92.9% for sedated ones.
  • Interobserver agreement was consistent as well, with figures of 92.8% for unsedated and 92.7% for sedated yearlings.
  • A significant correlation was discovered between CSARG and the laryngeal function grade for both groups.
  • The administration of drugs butorphanol and detomidine for sedation did not impact the laryngeal function grading.

Implication of the Research

  • This research is beneficial for veterinarians as it provides evidence that the administration of butorphanol and detomidine does not significantly affect grading of laryngeal function in young Thoroughbred horses, thus it can be employed without concerns about its impact on laryngeal assessment.

Cite This Article

APA
Almonte H, Schumacher J, Johnson CR, Berk JT, Bell RP. (2022). Effect of a combination of butorphanol and detomidine on endoscopic assessment of laryngeal function in Thoroughbred yearlings. Vet Rec, 190(9), e1483. https://doi.org/10.1002/vetr.1483

Publication

The Veterinary record
ISSN: 2042-7670
NlmUniqueID: 0031164
Country: England
Language: English
Volume: 190
Issue: 9
Pages: e1483

Researcher Affiliations

Almonte, Hugo
  • Park Equine Hospital, Lexington, Kentucky, USA.
Schumacher, James
  • Department of Large Animal Clinical Sciences, College of Veterinary Medicine University of Tennessee, Knoxville, Tennessee, USA.
Johnson, Christopher R
  • Park Equine Hospital, Lexington, Kentucky, USA.
Berk, Jeffrey T
  • Equine Medical Associates, Lexington, Kentucky, USA.
Bell, Rhodes P
  • Park Equine Hospital, Lexington, Kentucky, USA.

MeSH Terms

  • Animals
  • Arytenoid Cartilage
  • Butorphanol / pharmacology
  • Endoscopy / veterinary
  • Horses
  • Humans
  • Imidazoles
  • Larynx

References

This article includes 22 references
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