Analyze Diet
Animals : an open access journal from MDPI2024; 14(24); 3654; doi: 10.3390/ani14243654

Effect of Bio-Electro-Magnetic-Energy-Regulation (BEMER) Horse Therapy on Cardiopulmonary Function and Recovery Quality After Isoflurane Anesthesia in 100 Horses Subjected to Pars-Plana Vitrectomy: An Investigator-Blinded Clinical Study.

Abstract: The use of Bio-Electro-Magnetic-Energy-Regulation (BEMER) therapy during general anesthesia has not previously been reported in horses. This randomized, investigator-blinded, placebo-controlled trial evaluates equine cardiopulmonary function and recovery quality after BEMER therapy application for 15 min in 100 horses during general anesthesia using isoflurane for pars-plana vitrectomy surgery as treatment for recurrent uveitis. Visually identical blankets were used in the two groups (1:1 ratio), one with a functional BEMER module and the other with a placebo module. Arterial blood pressure, blood gas, lactate, and creatine kinase (CK) values were measured at different timepoints, and each timepoint was compared between the groups using paired t-tests. The quality of recovery from anesthesia was assessed by one blinded veterinary surgeon using a 10-category scoring system with scores ranging from 10 (best) to 72 (worst) and compared by an ordinary least squares regression analysis. The placebo group had a significantly better recovery (mean 16.1, standard deviation 7.15) than the BEMER-therapy group (mean 22.4, SD 13.0). Arterial blood pressure and blood lactate were lower in the BEMER-therapy group without reaching statistical significance, while CK and blood gas values were comparable. BEMER-horse therapy showed an effect on the recovery quality of horses undergoing general anesthesia.
Publication Date: 2024-12-18 PubMed ID: 39765558PubMed Central: PMC11672451DOI: 10.3390/ani14243654Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

Effect of Bio-Electro-Magnetic-Energy-Regulation (BEMER) horse therapy on heart and lung function and recovery quality after anesthesia was studied in horses undergoing eye surgery.

Study Background and Objective

  • This study investigated the impact of BEMER therapy, a bio-electro-magnetic energy treatment, during general anesthesia in horses.
  • The focus was on cardiopulmonary function and recovery quality after anesthesia with isoflurane for pars-plana vitrectomy, a surgery to treat recurrent uveitis in horses.
  • No prior research had examined BEMER therapy use in anesthetized horses.

Study Design

  • This was a randomized, investigator-blinded, placebo-controlled clinical trial involving 100 horses.
  • Horses were randomly assigned to two equal groups (1:1 ratio): one group received 15 minutes of BEMER therapy during anesthesia, and the other group received a placebo treatment with a visually identical blanket without active BEMER therapy.
  • The surgeon assessing recovery was blinded to group assignment to prevent bias.

Measurements and Data Collection

  • Key parameters measured at different time points during and after anesthesia included:
    • Arterial blood pressure
    • Blood gases (oxygen and carbon dioxide levels)
    • Blood lactate levels (indicator of tissue oxygenation and metabolic stress)
    • Creatine kinase (CK) levels (indicator of muscle damage)
  • A recovery quality score was recorded post-anesthesia using a detailed 10-category scale, ranging from 10 (best recovery) to 72 (worst recovery).
  • Statistical analysis was performed using paired t-tests for physiological parameters and ordinary least squares regression for recovery scores.

Results

  • The placebo group showed significantly better recovery scores than the BEMER therapy group:
    • Placebo mean recovery score: 16.1 (SD 7.15)
    • BEMER therapy mean recovery score: 22.4 (SD 13.0)
  • Arterial blood pressure and blood lactate levels were lower in the BEMER group, but these differences did not reach statistical significance.
  • CK and blood gas values were similar across both groups, indicating no significant muscle damage or changes in oxygen/carbon dioxide levels attributable to BEMER therapy.

Interpretation and Conclusions

  • BEMER therapy applied during general anesthesia had a noticeable effect on recovery quality, but unexpectedly, horses in the placebo group recovered better than those receiving BEMER therapy.
  • The therapy did not demonstrate significant benefits in key cardiopulmonary parameters (blood pressure, blood lactate, blood gases) or muscle damage markers compared to placebo.
  • The findings suggest that BEMER therapy may influence recovery quality negatively or that further research is required to clarify its effects and mechanisms in anesthetized horses.
  • Given no prior studies in this area, these results provide an initial evaluation but also call for caution in the clinical application of BEMER during equine anesthesia until more evidence is available.

Cite This Article

APA
Brandenberger O, Kalinovskiy A, Körner J, Genn H, Burger R, Leser S. (2024). Effect of Bio-Electro-Magnetic-Energy-Regulation (BEMER) Horse Therapy on Cardiopulmonary Function and Recovery Quality After Isoflurane Anesthesia in 100 Horses Subjected to Pars-Plana Vitrectomy: An Investigator-Blinded Clinical Study. Animals (Basel), 14(24), 3654. https://doi.org/10.3390/ani14243654

Publication

ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 14
Issue: 24
PII: 3654

Researcher Affiliations

Brandenberger, Olivier
  • Hanseklinik für Pferde, Karl-Benz-Straße 5-7, 27419 Sittensen, Germany.
Kalinovskiy, Andrey
  • Hanseklinik für Pferde, Karl-Benz-Straße 5-7, 27419 Sittensen, Germany.
Körner, Jens
  • Hanseklinik für Pferde, Karl-Benz-Straße 5-7, 27419 Sittensen, Germany.
Genn, Hermann
  • Pferdeklinik Mühlen, Münsterlandstraße 42, 49349 Steinfeld (Oldenburg), Germany.
Burger, Ralph
  • Medical Expert Center, BEMER Int. AG, Austrasse 15, 9495 Triesen, Liechtenstein.
Leser, Stephan
  • Hanseklinik für Pferde, Karl-Benz-Straße 5-7, 27419 Sittensen, Germany.

Grant Funding

  • no grant number / Bemer (Liechtenstein)

Conflict of Interest Statement

Ralph Burger is a paid consultant of BEMER Int. AG, Liechtenstein. The authors state that there are no other conflicts of interest regarding the publication of this article. Overall research funding played no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to submit the report for publication.

References

This article includes 35 references
  1. Creighton CM, Lemke KA, Lamont LA, Horney BS, Riley CB. Comparison of the Effects of Xylazine Bolus versus Medetomidine Constant Rate Infusion on Cardiopulmonary Function and Depth of Anesthesia in Horses Anesthetized with Isoflurane.. J. Am. Vet. Med. Assoc. 2012;240:991–997.
    doi: 10.2460/javma.240.8.991pubmed: 22471829google scholar: lookup
  2. Clark-Price SC. Recovery of Horses from Anesthesia.. Vet. Clin. N. Am. Equine Pract. 2013;29:223–242.
    doi: 10.1016/j.cveq.2012.11.001pubmed: 23498055google scholar: lookup
  3. Ida KK, Fantoni DT, Ibiapina BT, Souto M-TMR, Zoppa ALV, Silva LCLC, Ambrósio AM. Effect of Postoperative Xylazine Administration on Cardiopulmonary Function and Recovery Quality after Isoflurane Anesthesia in Horses.. Vet. Surg. 2013;42:877–884.
  4. Thurmon JC. General Clinical Considerations for Anesthesia of the Horse.. Vet. Clin. N. Am. Equine Pract. 1990;6:485–494.
    doi: 10.1016/S0749-0739(17)30526-6pubmed: 2282543google scholar: lookup
  5. Wagner AE. Complications in Equine Anesthesia.. Vet. Clin. N. Am. Equine Pract. 2008;24:735–752.
    doi: 10.1016/j.cveq.2008.10.002pubmed: 19203709google scholar: lookup
  6. Senior JM. Morbidity, Mortality, and Risk of General Anesthesia in Horses.. Vet. Clin. N. Am. Equine Pract. 2013;29:1–18.
    doi: 10.1016/j.cveq.2012.11.007pubmed: 23498043google scholar: lookup
  7. Dugdale AHA, Obhrai J, Cripps PJ. Twenty Years Later: A Single-Centre, Repeat Retrospective Analysis of Equine Perioperative Mortality and Investigation of Recovery Quality.. Vet. Anaesth. Analg. 2016;43:171–178.
    doi: 10.1111/vaa.12285pubmed: 26081190google scholar: lookup
  8. Dugdale AHA, Taylor PM. Equine Anaesthesia-Associated Mortality: Where Are We Now?. Vet. Anaesth. Analg. 2016;43:242–255.
    doi: 10.1111/vaa.12372pubmed: 26970940google scholar: lookup
  9. Clark-Price SC, Lascola KM, Carter JE, da Cunha AF, Donaldson LL, Doherty TJ, Martin-Flores M, Hofmeister EH, Keating SCJ, Mama KR. Assessment of Agreement among Diplomates of the American College of Veterinary Anesthesia and Analgesia for Scoring the Recovery of Horses from Anesthesia by Use of Subjective Grading Scales and Development of a System for Evaluation of the Recovery of Horses from Anesthesia by Use of Accelerometry.. Am. J. Vet. Res. 2017;78:668–676.
    doi: 10.2460/ajvr.78.6.668pubmed: 28541154google scholar: lookup
  10. Johnston GM, Eastment JK, Wood J, Taylor PM. The Confidential Enquiry into Perioperative Equine Fatalities (CEPEF): Mortality Results of Phases 1 and 2.. Vet. Anaesth. Analg. 2002;29:159–170.
  11. Krein SR, Lindsey JC, Blaze CA, Wetmore LA. Evaluation of Risk Factors, Including Fluconazole Administration, for Prolonged Anesthetic Recovery Times in Horses Undergoing General Anesthesia for Ocular Surgery: 81 Cases (2006–2013). J. Am. Vet. Med. Assoc. 2014;244:577–581.
    doi: 10.2460/javma.244.5.577pubmed: 24548232google scholar: lookup
  12. Curto EM, Griffith EH, Posner LP, Walsh KT, Balko JA, Gilger BC. Factors Associated with Postoperative Complications in Healthy Horses after General Anesthesia for Ophthalmic versus Non-Ophthalmic Procedures: 556 Cases (2012–2014). J. Am. Vet. Med. Assoc. 2018;252:1113–1119.
    doi: 10.2460/javma.252.9.1113pubmed: 29641332google scholar: lookup
  13. Voulgaris DA, Hofmeister EH. Multivariate Analysis of Factors Associated with Post-Anesthetic Times to Standing in Isoflurane-Anesthetized Horses: 381 Cases.. Vet. Anaesth. Analg. 2009;36:414–420.
  14. Wiederkehr A, Barbarossa A, Ringer SK, Jörger FB, Bryner M, Bettschart-Wolfensberger R. Clinical Randomized Comparison of Medetomidine and Xylazine for Isoflurane Balanced Anesthesia in Horses.. Front. Vet. Sci. 2021;8:603695.
    doi: 10.3389/fvets.2021.603695pmc: PMC8093396pubmed: 33959647google scholar: lookup
  15. Kälin I, Henze IS, Ringer SK, Torgerson PR, Bettschart-Wolfensberger R. Comparison of Recovery Quality Following Medetomidine versus Xylazine Balanced Isoflurane Anaesthesia in Horses: A Retrospective Analysis.. Animals 2021;11:2440.
    doi: 10.3390/ani11082440pmc: PMC8388745pubmed: 34438896google scholar: lookup
  16. Carlson BE, Arciero JC, Secomb TW. Theoretical Model of Blood Flow Autoregulation: Roles of Myogenic, Shear-Dependent, and Metabolic Responses.. Am. J. Physiol. Heart Circ. Physiol. 2008;295:H1572–H1579.
    doi: 10.1152/ajpheart.00262.2008pmc: PMC2593503pubmed: 18723769google scholar: lookup
  17. Bohn W, Hess L, Burger R. The Effects of the “Physical BEMER ® Vascular Therapy”, a Method for the Physical Stimulation of the Vasomotion of Precapillary Microvessels in Case of Impaired Microcirculation, on Sleep, Pain and Quality of Life of Patients with Different Clinical Pictures on the Basis of Three Scientifically Validated Scales.. J. Complement. Integr. Med. 2013;10:S5–S12.
    doi: 10.1515/jcim-2013-0037pubmed: 23940071google scholar: lookup
  18. Nawrot K, Soroko-Dubrovina M, Zielińska P, Dudek K, Howell K. The Application of Infrared Thermography in the Assessment of BEMER Physical Vascular Therapy on Body Surface Temperature in Racing Thoroughbreds: A Preliminary Study.. Animals 2024;14:1538.
    doi: 10.3390/ani14111538pmc: PMC11171224pubmed: 38891585google scholar: lookup
  19. Markov MS. Expanding Use of Pulsed Electromagnetic Field Therapies.. Electromagn. Biol. Med. 2007;26:257–274.
    doi: 10.1080/15368370701580806pubmed: 17886012google scholar: lookup
  20. Klopp RC, Niemer W, Schulz J. Complementary-Therapeutic Stimulation of Deficient Autorhythmic Arteriolar Vasomotion by Means of a Biorhythmically Physical Stimulus on the Microcirculation and the Immune System in 50-Year-Old Rehabilitation Patients.. J. Complement. Integr. Med. 2013;10:S29–S37.
    doi: 10.1515/jcim-2013-0034pubmed: 24021604google scholar: lookup
  21. Klopp RC, Niemer W, Schmidt W. Effects of Various Physical Treatment Methods on Arteriolar Vasomotion and Microhemodynamic Functional Characteristics in Case of Deficient Regulation of Organ Blood Flow. Results of a Placebo-Controlled, Double-Blind Study.. J. Complement. Integr. Med. 2013;10:S39–S46.
    doi: 10.1515/jcim-2013-0035pubmed: 24021606google scholar: lookup
  22. Benedetti MG, Cavazzuti L, Mosca M, Fusaro I, Zati A. Bio-Electro-Magnetic-Energy-Regulation (BEMER) for the Treatment of Type I Complex Regional Pain Syndrome: A Pilot Study.. Physiother. Theory Pract. 2020;36:498–506.
    doi: 10.1080/09593985.2018.1491661pubmed: 29985719google scholar: lookup
  23. Flatscher J, Pavez Loriè E, Mittermayr R, Meznik P, Slezak P, Redl H, Slezak C. Pulsed Electromagnetic Fields (PEMF)—Physiological Response and Its Potential in Trauma Treatment.. Int. J. Mol. Sci. 2023;24:11239.
    doi: 10.3390/ijms241411239pmc: PMC10379303pubmed: 37510998google scholar: lookup
  24. Luigi C, Tiziano P. Mechanisms of Action and Effects of Pulsed Electromagnetic Fields (PEMF) in Medicine.. .
  25. King M, Seabaugh K, Frisbie D. Effects of a Bio-Electromagnetic Energy Regulation Blanket on Thoracolumbar Epaxial Muscle Pain in Horses.. J. Equine Vet. Sci. 2022;111:103867.
    doi: 10.1016/j.jevs.2022.103867pubmed: 35081474google scholar: lookup
  26. Gaynor J, Hagberg S, Gurfein B. Veterinary Applications of Pulsed Electromagnetic Field Therapy.. Res. Vet. Sci. 2018;119:1–8.
    doi: 10.1016/j.rvsc.2018.05.005pubmed: 29775839google scholar: lookup
  27. Dai F, Costa ED, Giordano A, Heinzl EUL, Giongo P, Pagnozzi G, Cannas S, Minozzi G, Minero M. Effects of BEMER® Physical Vascular Therapy in Horses under Training. A Randomized, Controlled Double Blind Study.. Res. Vet. Sci. 2022;144:108–114.
    doi: 10.1016/j.rvsc.2022.01.017pubmed: 35114491google scholar: lookup
  28. Janotka M, Ostadal P. Biochemical Markers for Clinical Monitoring of Tissue Perfusion.. Mol. Cell. Biochem. 2021;476:1313–1326.
    doi: 10.1007/s11010-020-04019-8pmc: PMC7921020pubmed: 33387216google scholar: lookup
  29. Kafka WAPD. Vorrichtung zur Magnetfeldtherapie und zu Applizierendes Magnetfeldsignal.. EP2050481A1. 2009 April 22.
  30. Kafka WA. Bio-Elektro-Magnetische-Energie-Regulation (BEMER): Das physikalische Konzept und sein Einsatz bei Schmerz auslösenden Störungen.. In: Bernatzky G., Likar R., Wendtner F., Wenzel G., Ausserwinkler M., Sittl R., editors. Nichtmedikamentöse Schmerztherapie: Komplementäre Methoden in der Praxis. Springer; Vienna, Austria: 2007. pp. 299–317.
  31. Donaldson LL, Dunlop GS, Holland MS, Burton BA. The Recovery of Horses from Inhalant Anesthesia: A Comparison of Halothane and Isoflurane.. Vet. Surg. 2000;29:92–101.
  32. Piatkowski J, Kern S, Ziemssen T. Effect of BEMER Magnetic Field Therapy on the Level of Fatigue in Patients with Multiple Sclerosis: A Randomized, Double-Blind Controlled Trial.. J. Altern. Complement. Med. 2009;15:507–511.
    doi: 10.1089/acm.2008.0501pubmed: 19422286google scholar: lookup
  33. Farmer E, Chase-Topping M, Lawson H, Clutton RE. Factors Affecting the Perception of Recovery Quality in Horses after Anaesthesia.. Equine Vet. J. 2014;46:328–332.
    doi: 10.1111/evj.12133pubmed: 23819890google scholar: lookup
  34. Suthers JM, Christley RM, Clutton RE. Quantitative and Qualitative Comparison of Three Scoring Systems for Assessing Recovery Quality after General Anaesthesia in Horses.. Vet. Anaesth. Analg. 2011;38:352–362.
  35. Portier KG, Séna A, Senior M, Clutton RE. A Study of the Correlation between Objective and Subjective Indices of Recovery Quality after Inhalation Anaesthesia in Equids.. Vet. Anaesth. Analg. 2010;37:329–336.

Citations

This article has been cited 0 times.