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The Canadian veterinary journal = La revue veterinaire canadienne2009; 50(8); 821-827;

Effect of furosemide and furosemide-carbazochrome combination on exercise-induced pulmonary hemorrhage in Standardbred racehorses.

Abstract: The objective was to quantify the effect of furosemide and carbazochrome on exercise-induced pulmonary hemorrhage (EIPH) in Standardbred horses using red blood cell count and hemoglobin concentration in bronchoalveolar lavage (BAL) fluid. Six healthy Standardbred horses with prior evidence of EIPH performed a standardized treadmill test 4 h after administration of placebo, furosemide, or furosemide-carbazochrome combination. Red blood cell (RBC) counts and hemoglobin concentrations were determined on the BAL fluid. The RBC count in BAL ranges were (2903-26,025 cells/microL), (45-24,060 cells/microL), and (905-3045 cells/microL) for placebo, furosemide, and furosemide-carbazochrome, respectively. Hemoglobin concentration ranges were (0.03-0.59 mg/mL), (0.01-0.55 mg/mL), and (0.007-0.16 mg/mL) for placebo, furosemide, and furosemide-carbazochrome groups, respectively. No significant differences were detected among treatments. However, there was great variability among horses, suggesting that a larger sample size or better selection of horses was needed. L’objectif était de quantifier l’effet du furosémide et du carbazochrome sur l’hémorragie pulmonaire induite par l’exercice (HPIE) chez les chevaux Standardbred en utilisant la numération des globules rouges et la concentration d’hémoglobine dans le liquide de lavage bronchoalvéolaire (LBA). Six chevaux Standardbred en santé avec des signes antérieurs d’HPIE ont effectué un test normalisé sur tapis roulant 4 heures après l’administration du placebo, du furosémide ou de la combinaison furosémide–carbazochrome. Les numérations des globules rouges (GR) et les concentrations d’hémoglobine ont été déterminées à partir du liquide du LBA. Les intervalles de numération des GR dans le LBA était de [2903–26 025 cellules/μL], [445–24 060] et [905–3045] pour les groupes placebo, furosémide et furosémide–carbazochrome, respectivement. Les intervalles de concentration de l’hémoglobine étaient de [0,03–0,59 mg/mL], [0,01–0,55] et de [0,007–0,16] pour les groupes placebo, furosémide et furosémide — carbazochrome, respectivement. Aucune différence significative n’a été détectée parmi les traitements. Cependant, la variabilité entre les chevaux était très grande, suggérant qu’une taille d’échantillon plus importante ou une meilleure sélection des chevaux était requise. (Traduit par Isabelle Vallières)
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Publication Date: 2009-11-03 PubMed ID: 19881919PubMed Central: PMC2711466
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research examined the impact of furosemide and a furosemide-carbazochrome combo on exercise-induced pulmonary hemorrhage in Standardbred racehorses, measured through red blood cell count and hemoglobin concentration. No significant difference was found among the treatments, yet substantial variability among horses indicated the need for a larger sample size or improved selection of horses.

Objective of the Study

  • The aim of the research was to assess the effect of two treatments – furosemide and a combination of furosemide and carbazochrome, on the condition of exercise-induced pulmonary hemorrhage (EIPH) in Standardbred racehorses.
  • To measure the effect, researchers used the red blood cell (RBC) count and hemoglobin concentration in bronchoalveolar lavage (BAL) fluid. This fluid is collected from the lungs of horses and analyzed to determine the severity of EIPH.

Methods and Trial Procedure

  • Six healthy Standardbred horses with previous evidence of EIPH were selected.
  • They underwent a standard treadmill test four hours after the administration of either a placebo, furosemide, or a combination of furosemide and carbazochrome.
  • RBC counts and hemoglobin concentrations were determined using the collected BAL fluid.

Results of the Study

  • Despite differing ranges recorded for both measures in placebo, furosemide, and furosemide-carbazochrome groups, no significant differences were found among treatments.
  • The variability was high among horses, which suggested a larger sample size or better selection of horses may produce more accurate results in further studies.

Implications of the Research

  • While this research didn’t conclusively endorse the use of furosemide or its combination with carbazochrome for managing EIPH in Standardbred racehorses, it shed light on the need for more comprehensive studies.
  • The significant variability among individual horses underlines that a larger sample size could help attain better statistical validity and reliability. Additionally, refining the selection criteria for horses could contribute to more valuable results.

Cite This Article

APA
Perez-Moreno CI, Couëtil LL, Pratt SM, Ochoa-Acuña HG, Raskin RE, Russell MA. (2009). Effect of furosemide and furosemide-carbazochrome combination on exercise-induced pulmonary hemorrhage in Standardbred racehorses. Can Vet J, 50(8), 821-827.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 50
Issue: 8
Pages: 821-827

Researcher Affiliations

Perez-Moreno, Cecilia I
  • Animal Science, Purdue University, West Lafayette, Indiana 47906, USA.
Couëtil, Laurent L
    Pratt, Suzanne M
      Ochoa-Acuña, Hugo G
        Raskin, Rose E
          Russell, Mark A

            MeSH Terms

            • Adrenochrome / analogs & derivatives
            • Adrenochrome / therapeutic use
            • Animals
            • Bronchoalveolar Lavage Fluid / cytology
            • Cross-Over Studies
            • Diuretics / therapeutic use
            • Drug Therapy, Combination
            • Exercise Test / veterinary
            • Female
            • Furosemide / therapeutic use
            • Hemorrhage / drug therapy
            • Hemorrhage / veterinary
            • Horse Diseases / drug therapy
            • Horses
            • Lung Diseases / drug therapy
            • Lung Diseases / veterinary
            • Male
            • Physical Conditioning, Animal / adverse effects
            • Random Allocation
            • Treatment Outcome

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