Effect of isometamidium on infections by Trypanosoma vivax and T. evansi in experimentally-infected animals.
Abstract: Assays dealing with the therapeutic and prophylactic activity of isometamidium on experimental infections by Trypanosoma vivax and T. evansi were carried out. The drug was found to be highly effective against T. vivax infection in sheep and cattle in which periods of protection ranging from 118 to 195 days were achieved. No complete effects against infection by T. evansi were observed. The drug was well tolerated in sheep and cattle while side-effects were noted in treated mares. It was concluded that isometamidium could be used to prevent damage and economical losses caused by T. vivax in Venezuela.
Publication Date: 1983-08-01 PubMed ID: 6414154DOI: 10.1016/0304-4017(83)90018-3Google Scholar: Lookup
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- Journal Article
Summary
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This research investigates the effects of a drug called isometamidium on infections caused by two types of parasites, Trypanosoma vivax and T. evansi, in experimentally-infected animals. It found that the drug effectively protected sheep and cattle from T. vivax infection up to nearly 200 days, but did not show complete effects on T. evansi infections. Some side effects were observed in treated mares.
Objective of Research
- The primary objective of this research was to analyze the therapeutic and prophylactic (preventative) capabilities of a drug named isometamidium on infections caused by two species of parasites, Trypanosoma vivax and T. evansi. These infections were induced in animals under experimental conditions.
Methodology and Findings
- The researchers carried out detailed assays (tests) to discern the effect of the drug on both types of infections in animals.
- It was found that isometamidium had potent curative and preventive effects against T. vivax in sheep and cattle, with protective periods spanning from 118 to 195 days.
- However, the drug did not have full-fledged effects against T. evansi induced infections.
- In regards to the drug’s safety profile, it was well tolerated in sheep and cattle. However, some adverse side effects were noted in treated mares (female horses).
Conclusions drawn
- The study concluded that the drug isometamidium could be effectively used to prevent the damage and accompanying economic losses caused by T. vivax in the livestock population in Venezuela.
- Despite its potent protection against T. vivax, it did not offer complete protection against T. evansi infections, and care must be taken in its application in mares due to potential side effects.
Cite This Article
APA
Toro M, León E, López R, Pallota F, Garcia JA, Ruíz A.
(1983).
Effect of isometamidium on infections by Trypanosoma vivax and T. evansi in experimentally-infected animals.
Vet Parasitol, 13(1), 35-43.
https://doi.org/10.1016/0304-4017(83)90018-3 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Cattle
- Chagas Disease / parasitology
- Chagas Disease / prevention & control
- Chagas Disease / veterinary
- Female
- Goats
- Horse Diseases / parasitology
- Horse Diseases / prevention & control
- Horses
- Male
- Phenanthridines / therapeutic use
- Rats
- Rats, Inbred Strains
- Rodent Diseases / parasitology
- Rodent Diseases / prevention & control
- Species Specificity
- Trypanocidal Agents / therapeutic use
- Trypanosoma / drug effects
- Trypanosomiasis, Bovine / parasitology
- Trypanosomiasis, Bovine / prevention & control
Citations
This article has been cited 6 times.- More S, Bøtner A, Butterworth A, Calistri P, Depner K, Edwards S, Garin-Bastuji B, Good M, Gortázar Schmidt C, Michel V, Miranda MA, Nielsen SS, Raj M, Sihvonen L, Spoolder H, Stegeman JA, Thulke HH, Velarde A, Willeberg P, Winckler C, Baldinelli F, Broglia A, Candiani D, Beltrán Beck B, Kohnle L, Morgado J, Bicout D. Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): Trypanosoma evansi infections (including Surra). EFSA J 2017 Jul;15(7):e04892.
- Mekonnen G, Mohammed EF, Kidane W, Nesibu A, Yohannes H, Van Reet N, Büscher P, Birhanu H. Isometamidium chloride and homidium chloride fail to cure mice infected with Ethiopian Trypanosoma evansi type A and B. PLoS Negl Trop Dis 2018 Sep;12(9):e0006790.
- Giordani F, Morrison LJ, Rowan TG, DE Koning HP, Barrett MP. The animal trypanosomiases and their chemotherapy: a review. Parasitology 2016 Dec;143(14):1862-1889.
- Desquesnes M, Dargantes A, Lai DH, Lun ZR, Holzmuller P, Jittapalapong S. Trypanosoma evansi and surra: a review and perspectives on transmission, epidemiology and control, impact, and zoonotic aspects. Biomed Res Int 2013;2013:321237.
- Kumar U, Jas R, Ghosh JD. Effect of isometamidium hydrochloride on Trypanosoma evansi infections in rats. J Parasit Dis 2009 Dec;33(1-2):36-41.
- Ali BH. A survey of some drugs commonly used in the camel. Vet Res Commun 1988;12(1):67-75.
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