Effective priming of foals born to immune dams against influenza by a canarypox-vectored recombinant influenza H3N8 vaccine.
Abstract: A classical limitation of early life immunization is the interference by maternally derived antibodies, which are known to inhibit the immune response to modified-live and killed vaccines. Several studies have convincingly shown that even minute amounts of maternally derived antibodies against equine influenza can strongly interfere with successful vaccination of foals born to immune mares. In this study we evaluated the response of foals born to vaccinated mares to immunization with a canarypox-vectored recombinant vaccine against equine influenza virus H3N8. The recombinant vaccine was able to efficiently prime foals in the presence of maternally derived immunity against influenza as was evidenced by a clear anamnestic antibody response when a secondary vaccination with the same vaccine was performed. The canarypox-vectored recombinant influenza vaccine therefore offers a unique opportunity to overcome the limitations of early life vaccination in the face of maternally derived immunity in foals.
Publication Date: 2007-06-07 PubMed ID: 17559865DOI: 10.1016/j.jcpa.2007.04.016Google Scholar: Lookup
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- Journal Article
Summary
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This research article explores the effective use of a canarypox-vectored recombinant vaccine to prime foals, born to already immune mares, against equine influenza virus H3N8 despite the presence of maternally-derived antibodies that typically hinder early life immunization.
Introduction and Background
- The research builds on the problematic nature of early life immunization of foals, particularly those that inherit antibodies from immune mothers.
- Maternally derived antibodies are known to inhibit the immune response to vaccines, posing a significant challenge to successful vaccination.
- Particularly, even tiny amounts of these maternally derived antibodies against equine influenza can greatly interfere with the successful vaccination of foals born to immune mares.
Investigative Approach
- In this study, the research team studied the response of foals born to vaccinated mares when immunized with a canarypox-vectored recombinant vaccine against the equine influenza virus H3N8.
Results
- The recombinant vaccine was found to be effective in priming the foals against influenza, in spite of the presence of maternally-derived immunity.
- This was proven by a clear anamnestic (memory-aiding) antibody response observed when a secondary vaccination with the same vaccine was performed.
Conclusion
- The results suggest that the canarypox-vectored recombinant influenza vaccine provides an efficient solution to overcome the limitations of early life immunization, specifically in the presence of maternally-derived immunity in foals.
- This could dramatically enhance the success rate of later vaccination for equine influenza, posing a great opportunity for improving immunization protocols in horse breeding and veterinary practices.
Cite This Article
APA
Minke JM, Toulemonde CE, Dinic S, Cozette V, Cullinane A, Audonnet JC.
(2007).
Effective priming of foals born to immune dams against influenza by a canarypox-vectored recombinant influenza H3N8 vaccine.
J Comp Pathol, 137 Suppl 1, S76-S80.
https://doi.org/10.1016/j.jcpa.2007.04.016 Publication
Researcher Affiliations
- Merial SAS Research and Development, 254 rue Marcel Mérieux, 69007 Lyon, France. Jules.Minke@merial.com
MeSH Terms
- Animals
- Antibodies, Viral / immunology
- Antibodies, Viral / metabolism
- Canarypox virus / genetics
- Canarypox virus / immunology
- Cross-Priming / immunology
- Female
- Horse Diseases / immunology
- Horse Diseases / prevention & control
- Horse Diseases / virology
- Horses
- Immunity, Maternally-Acquired / immunology
- Influenza A Virus, H3N8 Subtype / immunology
- Influenza Vaccines / immunology
- Influenza Vaccines / therapeutic use
- Male
- Orthomyxoviridae / genetics
- Orthomyxoviridae / immunology
- Orthomyxoviridae Infections / immunology
- Orthomyxoviridae Infections / prevention & control
- Orthomyxoviridae Infections / veterinary
- Vaccination / methods
- Vaccination / veterinary
- Vaccines, Synthetic / immunology
- Vaccines, Synthetic / therapeutic use
Citations
This article has been cited 9 times.- Oladunni FS, Oseni SO, Martinez-Sobrido L, Chambers TM. Equine Influenza Virus and Vaccines.. Viruses 2021 Aug 20;13(8).
- Tallmadge RL, Miller SC, Parry SA, Felippe MJB. Antigen-specific immunoglobulin variable region sequencing measures humoral immune response to vaccination in the equine neonate.. PLoS One 2017;12(5):e0177831.
- Na W, Yeom M, Yuk H, Moon H, Kang B, Song D. Influenza virus vaccine for neglected hosts: horses and dogs.. Clin Exp Vaccine Res 2016 Jul;5(2):117-24.
- de Vries RD, Rimmelzwaan GF. Viral vector-based influenza vaccines.. Hum Vaccin Immunother 2016 Nov;12(11):2881-2901.
- Paillot R, El-Hage CM. The Use of a Recombinant Canarypox-Based Equine Influenza Vaccine during the 2007 Australian Outbreak: A Systematic Review and Summary.. Pathogens 2016 Jun 10;5(2).
- Paillot R. A Systematic Review of Recent Advances in Equine Influenza Vaccination.. Vaccines (Basel) 2014 Nov 14;2(4):797-831.
- Gildea S, Arkins S, Cullinane A. A comparative antibody study of the potential susceptibility of Thoroughbred and non-Thoroughbred horse populations in Ireland to equine influenza virus.. Influenza Other Respir Viruses 2010 Nov;4(6):363-72.
- Brun A, Albina E, Barret T, Chapman DA, Czub M, Dixon LK, Keil GM, Klonjkowski B, Le Potier MF, Libeau G, Ortego J, Richardson J, Takamatsu HH. Antigen delivery systems for veterinary vaccine development. Viral-vector based delivery systems.. Vaccine 2008 Dec 2;26(51):6508-28.
- Rosas C, Van de Walle GR, Metzger SM, Hoelzer K, Dubovi EJ, Kim SG, Parrish CR, Osterrieder N. Evaluation of a vectored equine herpesvirus type 1 (EHV-1) vaccine expressing H3 haemagglutinin in the protection of dogs against canine influenza.. Vaccine 2008 May 2;26(19):2335-43.
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