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Frontiers in veterinary science2021; 8; 678453; doi: 10.3389/fvets.2021.678453

Effectiveness of Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate as Treatments for Chronic Hindlimb Proximal Suspensory Desmopathy.

Abstract: This retrospective study aimed to evaluate the clinical effect of bone marrow aspirate concentrate (BMAC) and leukocyte rich PRP (LR-PRP) compared to horses undergoing controlled exercise alone in horses with >3 months proximal suspensory desmopathy in hindlimbs (HPSD). Nighty-three horses were divided into three groups according to the treatment: a control (n = 22), LR-PRP (n = 46), and BMAC (n = 25) group. Lameness and ultrasound scores were recorded before treatment (T0) and at 6 months (T1) post-treatment. Records horses considered sound at evaluation and level of performance were additionally registered at 12 months (T2) and 18 months (T3) after treatment. The BMAC cytology profiles from 22 horses were also analysed and compared to clinical outcomes. The results at T1 showed that 9% (2/22) of the horses in the control group were sound compared to 59% (25/46) and 84% (21/25) in the LR-PRP and BMAC groups, respectively. Additionally, ultrasound scores at T1 in the BMAC and LR-PRP groups were improved in comparison with the control group (p = 0.02). At T2, 68% of the horses in the BMAC group and 39% of the horses in the LR-PRP group had returned to the previous performance level. At T3, a significantly higher percentage of horses in the LR-PRP (43%) and BMAC (72%) group were sound when compared to the control (4.6%) group (p = 0.02). Similarly, at T3, significantly more horses of the BMAC (16/25) and of the LR-PRP (15/46) group had returned to the previous or a higher performance level compared to the control (1/22) group (p = 0.01). No correlation was found between long-term clinical outcome and cytology profiles in the BMAC group. In conclusion, long-term outcomes of treatment with LR-PRP or BMAC are significantly better than conventional treatment of the hindlimb chronic PSD in horses. Additionally, BMAC yielded better lameness scores than LR-PRP at short- and long-term follow-up.
Copyright © 2021 Maleas and Mageed.
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Publication Date: 2021-06-18 PubMed ID: 34222402PubMed Central: PMC8253571DOI: 10.3389/fvets.2021.678453Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The article focuses on the comparison of bone marrow aspirate concentrate (BMAC) and leukocyte rich platelet-rich plasma (LR-PRP) as treatments for chronic proximal suspensory desmopathy in horse hindlimbs, over a duration of more than three months.

Study Design and Participants

  • The retrospective study involves ninety-three horses categorized into three different groups. These groups were based on the treatment method – control, LR-PRP, and BMAC.
  • Researchers observed and assessed lameness and ultrasound scores of these horses prior to treatment (T0) and six months following treatment (T1).
  • Additional records were maintained for horses that showed no signs of lameness and their performance levels were registered at 12 months (T2) and 18 months (T3) following treatment.
  • The BMAC cytology profiles from 22 horses were cross-analyzed with clinical outcomes.

Findings

  • At T1, 9% of the horses in the control group were found sound compared to 59% and 84% in the LR-PRP and BMAC groups, respectively.
  • Ultrasound scores were significantly improved in the BMAC and LR-PRP groups in comparison with the control group at T1.
  • At T2 post-treatment, 68% of BMAC horses and 39% of LR-PRP horses had returned to their previous performance levels.
  • At T3, significantly more horses in the LR-PRP (43%) and BMAC (72%) groups showed no lameness when compared to the control group (4.6%).
  • At T3, 16 out of 25 horses in the BMAC group and 15 out of 46 horses in the LR-PRP group had returned to their previous or higher performance levels, as compared to just 1 out of 22 horses in the control group.
  • No correlation was found between long-term clinical outcome and cytology profiles in the BMAC group.

Conclusion

  • The study confirms that treatment outcomes with LR-PRP or BMAC were significantly better for chronic hindlimb PSD in horses when compared to traditional treatment methods.
  • Additionally, BMAC resulted in better lameness scores than LR-PRP at both short- and long-term follow-ups.

Cite This Article

APA
Maleas G, Mageed M. (2021). Effectiveness of Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate as Treatments for Chronic Hindlimb Proximal Suspensory Desmopathy. Front Vet Sci, 8, 678453. https://doi.org/10.3389/fvets.2021.678453

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 8
Pages: 678453

Researcher Affiliations

Maleas, Grigorios
  • Tierklinik in Lüsche GmbH, Bakum, Germany.
Mageed, Mahmoud
  • Tierklinik in Lüsche GmbH, Bakum, Germany.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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