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Home / Equine Research Bank / Front Vet Sci / Effectiveness of Platelet-Rich Plasma and Bone Marrow Aspira...
Frontiers in veterinary science2021; 8; 678453; doi: 10.3389/fvets.2021.678453

Effectiveness of Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate as Treatments for Chronic Hindlimb Proximal Suspensory Desmopathy.

Abstract: This retrospective study aimed to evaluate the clinical effect of bone marrow aspirate concentrate (BMAC) and leukocyte rich PRP (LR-PRP) compared to horses undergoing controlled exercise alone in horses with >3 months proximal suspensory desmopathy in hindlimbs (HPSD). Nighty-three horses were divided into three groups according to the treatment: a control (n = 22), LR-PRP (n = 46), and BMAC (n = 25) group. Lameness and ultrasound scores were recorded before treatment (T0) and at 6 months (T1) post-treatment. Records horses considered sound at evaluation and level of performance were additionally registered at 12 months (T2) and 18 months (T3) after treatment. The BMAC cytology profiles from 22 horses were also analysed and compared to clinical outcomes. The results at T1 showed that 9% (2/22) of the horses in the control group were sound compared to 59% (25/46) and 84% (21/25) in the LR-PRP and BMAC groups, respectively. Additionally, ultrasound scores at T1 in the BMAC and LR-PRP groups were improved in comparison with the control group (p = 0.02). At T2, 68% of the horses in the BMAC group and 39% of the horses in the LR-PRP group had returned to the previous performance level. At T3, a significantly higher percentage of horses in the LR-PRP (43%) and BMAC (72%) group were sound when compared to the control (4.6%) group (p = 0.02). Similarly, at T3, significantly more horses of the BMAC (16/25) and of the LR-PRP (15/46) group had returned to the previous or a higher performance level compared to the control (1/22) group (p = 0.01). No correlation was found between long-term clinical outcome and cytology profiles in the BMAC group. In conclusion, long-term outcomes of treatment with LR-PRP or BMAC are significantly better than conventional treatment of the hindlimb chronic PSD in horses. Additionally, BMAC yielded better lameness scores than LR-PRP at short- and long-term follow-up.
Copyright © 2021 Maleas and Mageed.
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Publication Date: 2021-06-18 PubMed ID: 34222402PubMed Central: PMC8253571DOI: 10.3389/fvets.2021.678453Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The article focuses on the comparison of bone marrow aspirate concentrate (BMAC) and leukocyte rich platelet-rich plasma (LR-PRP) as treatments for chronic proximal suspensory desmopathy in horse hindlimbs, over a duration of more than three months.

Study Design and Participants

  • The retrospective study involves ninety-three horses categorized into three different groups. These groups were based on the treatment method – control, LR-PRP, and BMAC.
  • Researchers observed and assessed lameness and ultrasound scores of these horses prior to treatment (T0) and six months following treatment (T1).
  • Additional records were maintained for horses that showed no signs of lameness and their performance levels were registered at 12 months (T2) and 18 months (T3) following treatment.
  • The BMAC cytology profiles from 22 horses were cross-analyzed with clinical outcomes.

Findings

  • At T1, 9% of the horses in the control group were found sound compared to 59% and 84% in the LR-PRP and BMAC groups, respectively.
  • Ultrasound scores were significantly improved in the BMAC and LR-PRP groups in comparison with the control group at T1.
  • At T2 post-treatment, 68% of BMAC horses and 39% of LR-PRP horses had returned to their previous performance levels.
  • At T3, significantly more horses in the LR-PRP (43%) and BMAC (72%) groups showed no lameness when compared to the control group (4.6%).
  • At T3, 16 out of 25 horses in the BMAC group and 15 out of 46 horses in the LR-PRP group had returned to their previous or higher performance levels, as compared to just 1 out of 22 horses in the control group.
  • No correlation was found between long-term clinical outcome and cytology profiles in the BMAC group.

Conclusion

  • The study confirms that treatment outcomes with LR-PRP or BMAC were significantly better for chronic hindlimb PSD in horses when compared to traditional treatment methods.
  • Additionally, BMAC resulted in better lameness scores than LR-PRP at both short- and long-term follow-ups.

Cite This Article

APA
Maleas G, Mageed M. (2021). Effectiveness of Platelet-Rich Plasma and Bone Marrow Aspirate Concentrate as Treatments for Chronic Hindlimb Proximal Suspensory Desmopathy. Front Vet Sci, 8, 678453. https://doi.org/10.3389/fvets.2021.678453

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 8
Pages: 678453

Researcher Affiliations

Maleas, Grigorios
  • Tierklinik in Lüsche GmbH, Bakum, Germany.
Mageed, Mahmoud
  • Tierklinik in Lüsche GmbH, Bakum, Germany.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

This article includes 56 references
  1. Dyson S. Proximal suspensory desmitis in the hindlimb: 42 cases.. Br Vet J (1994) 3:279–91.
    doi: 10.1016/S0007-1935(05)80008-9pubmed: 8044668google scholar: lookup
  2. Murray RC, Dyson SJ, Tranquille C, Adams V. Anatomical site of orthopaedic injury diagnosis.. Equine Vet J (2006) 36:411–6.
    doi: 10.1111/j.2042-3306.2006.tb05578.xpubmed: 17402457google scholar: lookup
  3. Dyson S. Proximal suspensory desmitis: clinical, ultrasonographic, and radiographic features.. Equine Vet. J. (1991) 23:25–31.
    doi: 10.1111/j.2042-3306.1991.tb02708.xpubmed: 2015804google scholar: lookup
  4. Lischer CJ, Ringer SK, Schnewlin M, Imboden I, Fürst A, Stöckli M. Treatment of chronic proximal suspensory desmitis in horses using focused electrohydraulic shockwave therapy.. Schweiz Arch Tierheilkd (2006) 10:561–8.
    doi: 10.1024/0036-7281.148.10.561pubmed: 17076464google scholar: lookup
  5. Dyson SJ, Genovese RL. The suspensory apparatus.. In: Ross M, Dyson S, editors. Diagnosis and Management of Lameness in the Horse, 2nd Edn. Philadelphia, PA: Saunders; (2010). p. 738–60..
  6. Crowe OM, Dyson SJ, Wright IM, Schramme MC, Smith RKW. Treatment of chronic or recurrent proximal suspensory desmitis using radial pressure wave therapy in the horse.. Equine Vet J (2004) 36:313–6.
    doi: 10.2746/0425164044890562pubmed: 15163037google scholar: lookup
  7. Waselau M, Sutter WW, Genovese RL, Bertone AL. Intralesional injection of platelet-rich plasma followed by controlled exercise for treatment midbody suspensory ligament desmitis in Standardbred racehorses.. J Am Vet Med Assoc (2008) 232:1515–20.
    doi: 10.2460/javma.232.10.1515pubmed: 18479242google scholar: lookup
  8. Geburek F, Gaus M, Van Schie HTM, Rohn K, Stadler PM. Effect of intralesional platelet-rich plasma (PRP) treatment on clinical and ultrasonographic parameters in equine naturally occurring superficial digital flexor tendinopathies-a randomized prospective controlled clinical trial.. BMC Vet Res (2016) 12:191.
    doi: 10.1186/s12917-016-0826-1pmc: PMC5015224pubmed: 27604193google scholar: lookup
  9. Giunta K, Donnell JR, Donnell AD, Frisbie DD. Prospective randomized comparison of platelet rich plasma to extracorporeal shockwave therapy for treatment of proximal suspensory pain in western performance horses.. Res Vet Sci (2019) 126:38–44.
    doi: 10.1016/j.rvsc.2019.07.020pubmed: 31430578google scholar: lookup
  10. Scala M, Lenarduzzi S, Spagnolo F, Trapasso M, Ottonello C, Muraglia A. Regenerative medicine for the treatment of teno-desmic injuries of the equine. A series of 150 horses treated with platelet-derived growth factors.. In Vivo (2014) 28:1119–23.
    pubmed: 25398809
  11. Smith RKW. Mesenchymal stem cell therapy for equine tendinopathy.. Disabil Rehabil (2008) 30:1752–8.
    doi: 10.1080/09638280701788241pubmed: 18608378google scholar: lookup
  12. Brossi PM, Moreira JJ, Machado TS, Baccarin RY. Platelet-rich plasma in orthopedic therapy: a comparative systematic review of clinical and experimental data in equine and human musculoskeletal lesions.. BMC Vet Res (2015) 11:98.
    doi: 10.1186/s12917-015-0403-zpmc: PMC4449579pubmed: 25896610google scholar: lookup
  13. Bosch G, Moleman M, Barneveld A, van Weeren PR, van Schie HTM. The effect of platelet-rich plasma on the neovascularization of surgically created equine superficial digital flexor tendon lesions.. Scand J Med Sci Sports (2011) 21:554–61.
    doi: 10.1111/j.1600-0838.2009.01070.xpubmed: 20459479google scholar: lookup
  14. Rich FR. Single-center study of 83 horses with suspensory injuries treated with adipose-derived stem and regenerative cells.. Stem Cell Discov (2014) 4:44–53.
    doi: 10.4236/scd.2014.42005google scholar: lookup
  15. Burk J, Brehm W. Stammzellentherapie von Sehnenverletzungen - klinische Ergebnisse von 98 Fällen.. Pferdeheilkunde (2011) 27:153–61.
    doi: 10.21836/PEM20110207google scholar: lookup
  16. Faltus T, Brehm W. Cell-based veterinary pharmaceuticals - basic legal parameters set by the veterinary pharmaceutical law and the genetic engineering law of the European Union.. Front Vet Sci (2016) 3:101.
    doi: 10.3389/fvets.2016.00101pmc: PMC5127790pubmed: 27965965google scholar: lookup
  17. Fortier LA, Potter HG, Rickey EJ, Schnabel LV, Foo LF, Chong LR. Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in the equine model.. J Bone Jt Surg (2010) 92:1927–37.
    doi: 10.2106/JBJS.I.01284pubmed: 20720135google scholar: lookup
  18. Imam MA, Holton J, Horriat S, Negida AS, Grubhofer F, Gupta R. A systematic review of the concept and clinical applications of bone marrow aspirate concentrate in tendon pathology.. SICOT (2017) 3:1–9.
    doi: 10.1051/sicotj/2017039pmc: PMC5632955pubmed: 28990575google scholar: lookup
  19. Smith JJ, Ross MW, Smith RKW. Anabolic effects of acellular bone marrow, platelet rich plasma, and serum on equine suspensory ligament fibroblasts in vitro.. Vet Comp Orthop Traumatol (2006) 19:43–7.
    doi: 10.1055/s-0038-1632972pubmed: 16594543google scholar: lookup
  20. Herthel DJ. Enhanced suspensory ligament healing in 100 horses by stem cells and other bone marrow components.. Proc Annu Conv Am Assoc Equine Pract (2001) 47:319–21.
  21. Swanson TD. Guide for Veterinary Service and Judging of Equestrian Events, 3rd Edn.. Golden, CO: American Association Equine Practitiners; (1984). 24 p..
  22. Denoix JM, Farres D. Ultrasonographic imagingof the proximal third interosseus muscle in the pelvic limb using a plantaromedial approach.. J Equine Vet Sci (1995) 15:346–50.
    doi: 10.1016/S0737-0806(07)80544-2google scholar: lookup
  23. Hessel LN, Bosch G, van Weeren PR, Ionita J-C. Equine autologous platelet concentrates: a comparative study between different available systems.. Equine Vet J (2015) 47:319–25.
    doi: 10.1111/evj.12288pubmed: 24773596google scholar: lookup
  24. Delling U, Lindner K, Ribitsch I, Jülke H, Brehm W. Comparison of bone marrow aspiration at the sternum and the tuber coxae in middle-aged horses.. Can J Vet Res (2012) 76:52–6.
    pmc: PMC3244288pubmed: 22754095
  25. Broyles JE, O'Brien MA, Patrick SM. Microdrilling surgery augmented with intra-articular bone marrow aspirate concentrate, platelet-rich plasma, and hyaluronic acid: a technique for cartilage repair in the knee.. Arthrosc Tech (2017) 6:201–6.
    doi: 10.1016/j.eats.2016.09.024pmc: PMC5382283pubmed: 28409101google scholar: lookup
  26. Carrozzo U, Toniato M, Harrison A. Assessment of noninvasive low-frequency ultrasound as a means of treating injuries to suspensory ligaments in horses : a research paper.. J Equine Vet Sci (2019) 80:80–9.
    doi: 10.1016/j.jevs.2019.07.007pubmed: 31443840google scholar: lookup
  27. Pluim M, Martens A, Vanderperren K, Sarrazin S, Koene M, Luciani A. Short- and long term follow-up of 150 sports horses diagnosed with tendinopathy or desmopathy by ultrasonographic examination and treated with high-power laser therapy.. Res Vet Sci (2018) 119:232–8.
    doi: 10.1016/j.rvsc.2018.06.003pubmed: 30005398google scholar: lookup
  28. Ntege EH, Sunami H, Shimizu Y. Advances in regenerative therapy: a review of the literature and future directions.. Regen Ther (2020) 14:136–53.
    doi: 10.1016/j.reth.2020.01.004pmc: PMC7033303pubmed: 32110683google scholar: lookup
  29. Jiang G, Wu Y, Meng J, Wu F, Li S, Lin M. Comparison of leukocyte-rich platelet-rich plasma and leukocyte-poor platelet-rich plasma on achilles tendinopathy at an early stage in a rabbit model.. Am J Sports Med (2020) 48:1189–99.
    doi: 10.1177/0363546520906142pubmed: 32134682google scholar: lookup
  30. Lana JF, Huber SC, Purita J, Tambeli CH, Santos GS, Paulus C. Leukocyte-rich PRP versus leukocyte-poor PRP - The role of monocyte/macrophage function in the healing cascade.. J Clin Orthop Trauma (2019) 10:7–12.
    doi: 10.1016/j.jcot.2019.05.008pmc: PMC6823808pubmed: 31700202google scholar: lookup
  31. Parrish WR, Roides B, Hwang J, Mafilios M, Story B, Bhattacharyya S. Normal platelet function in platelet concentrates requires non-platelet cells: a comparative in vitro evaluation of leucocyte-rich (type 1a) and leucocyte-poor (type 3b) platelet concentrates.. BMJ Open Sport Exerc Med (2016) 2:e000071.
    doi: 10.1136/bmjsem-2015-000071pmc: PMC5117029pubmed: 27900155google scholar: lookup
  32. Moojen DJF, Everts PAM, Schure R, Overdevest EP, van Zundert A, Knape JTA. Antimicrobial activity of platelet-leukocyte gel against Staphylococcus aureus.. J Orthop Res (2008) 26:404–10.
    doi: 10.1002/jor.20519pubmed: 17960651google scholar: lookup
  33. Seabaugh KA, Thoresen M, Giguère S. Extracorporeal shockwave therapy increases growth factor release from equine platelet-rich plasma in vitro.. Front Vet Sci (2017) 4:205.
    doi: 10.3389/fvets.2017.00205pmc: PMC5726030pubmed: 29270410google scholar: lookup
  34. Kaux J, Libertiaux V, Dupont L, Colige A, Lecut C, Hego A. Platelet-rich plasma (PRP) and tendon healing : comparison between fresh and frozen-thawed PRP.. Platelets (2019) 30:221–5.
    doi: 10.1080/09537104.2019.1595563pubmed: 30915890google scholar: lookup
  35. Chahla J, Kennedy MI, Aman ZS, Laprade RF. Ortho-biologics for ligament repair and reconstruction.. Clin Sports Med (2019) 38:97–107.
    doi: 10.1016/j.csm.2018.08.003pubmed: 30466725google scholar: lookup
  36. Liu XN, Yang C-J, Kim JE, Du ZW, Ren M, Zhang W. Enhanced tendon-to-bone healing of chronic rotator cuff tears by bone marrow aspirate concentrate in a rabbit model.. Clin Orthop Surg (2018) 10:99–110.
    doi: 10.4055/cios.2018.10.1.99pmc: PMC5851862pubmed: 29564054google scholar: lookup
  37. Schnabel LV, Mohammed HO, Jacobson MS, Fortier LA. Effects of platelet rich plasma and acellular bone marrow on gene expression patterns and DNA content of equine suspensory ligament explant cultures.. Equine Vet J (2008) 40:260–5.
    doi: 10.2746/042516408X278030pubmed: 18267879google scholar: lookup
  38. Lacitignola L, Crovace A, Rossi G, Francioso E. Cell therapy for tendinitis, experimental and clinical report.. Vet Res Commun (2008) 32:33–8.
    doi: 10.1007/s11259-008-9085-3pubmed: 18686004google scholar: lookup
  39. Hou L, Kim JJ, Woo YJ, Huang NF. Stem cell-based therapies to promote angiogenesis in ischemic cardiovascular disease.. Am J Physiol Circ Physiol (2016) 310:455–65.
    doi: 10.1152/ajpheart.00726.2015pmc: PMC4796616pubmed: 26683902google scholar: lookup
  40. Du F, Wang Q, Ouyang L, Wu H, Yang Z, Fu X. Comparison of concentrated fresh mononuclear cells and cultured mesenchymal stem cells from bone marrow for bone regeneration.. Stem Cells Transl Med (2020) 10:598–609.
    doi: 10.1002/sctm.20-0234pmc: PMC7980203pubmed: 33341102google scholar: lookup
  41. Rouwkema J, Khademhosseini A. Vascularization and angiogenesis in tissue engineering: beyond creating static networks.. Trends Biotechnol (2016) 34:733–45.
    doi: 10.1016/j.tibtech.2016.03.002pubmed: 27032730google scholar: lookup
  42. Yanishi K, Shoji K, Fujioka A, Hori Y, Yukawa A, Matoba S. Impact of therapeutic angiogenesis using autologous bone marrow-derived mononuclear cell implantation in patients with no-option critical limb ischemia.. Ann Vasc Dis (2020) 13:13–22.
    doi: 10.3400/avd.ra.20-00002pmc: PMC7140169pubmed: 32273917google scholar: lookup
  43. Schnabel LV, Mohammed HO, Miller BJ, Mcdermott WG, Jacobson MS, Santangelo KS. Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons.. J Orthop Res (2007) 25:230–40.
    doi: 10.1002/jor.20278pubmed: 17106885google scholar: lookup
  44. Radcliffe CH, Flaminio MJBF, Fortier LA. Temporal analysis of equine bone marrow aspirate during establishment of putative mesenchymal progenitor cell populations.. Stem Cells Dev (2010) 19:269–81.
    doi: 10.1089/scd.2009.0091pmc: PMC3138180pubmed: 19604071google scholar: lookup
  45. Wise JK, Alford AI, Goldstein SA, Stegemann JP. Comparison of uncultured marrow mononuclear cells and culture-expanded mesenchymal stem cells in 3d collagen-chitosan microbeads for orthopedic tissue engineering.. Tissue Eng Part A (2014) 20:210–24.
    doi: 10.1089/ten.tea.2013.0151pmc: PMC3875201pubmed: 23879621google scholar: lookup
  46. Qian Y, Han Q, Chen W, Song J, Zhao X. Platelet-rich plasma derived growth factors contribute to stem cell differentiation in musculoskeletal regeneration.. Front Chem (2017) 5:89.
    doi: 10.3389/fchem.2017.00089pmc: PMC5671651pubmed: 29164105google scholar: lookup
  47. Dyson S. Diagnosis and management of common suspensory lesions in the forelimbs and hindlimbs of sport horses.. Clin Tech Equine Pract (2007) 3:179–88.
    doi: 10.1053/j.ctep.2007.08.004google scholar: lookup
  48. Dyson S, Murray R. Management of hindlimb proximal suspensory desmopathy by neurectomy of the deep branch of the lateral plantar nerve and plantar fasciotomy: 155 horses (2003-2008).. Equine Vet J (2012) 44:361–7.
    doi: 10.1111/j.2042-3306.2011.00445.xpubmed: 21883416google scholar: lookup
  49. Dyson S, Murray R, Pinilla M-J. Proximal suspensory desmopathy in hindlimbs: a correlative clinical, ultrasonographic, gross post mortem and histological study.. Equine Vet J (2017) 49:65–72.
    doi: 10.1111/evj.12563pubmed: 26713512google scholar: lookup
  50. Tóth F, Schumacher J, Schramme M, Holder T, Adair HS, Donnell RL. Compressive damage to the deep branch of the lateral plantar nerve associated with lameness caused by proximal suspensory desmitis.. Vet Surg (2008) 37:328–35.
    doi: 10.1111/j.1532-950X.2008.00385.xpubmed: 18564256google scholar: lookup
  51. Labens R, Schramme MC, Robertson ID, Thrall DE, Redding WR. Clinical, magnetic resonance, and sonographic imaging findings in horses with proximal plantar metatarsal pain.. Vet Radiol Ultrasound (2010) 51:11–8.
    doi: 10.1111/j.1740-8261.2009.01614.xpubmed: 20166387google scholar: lookup
  52. Bischofberger AS, Konar M, Ohlerth S, Geyer H, Lang J, Ueltschi G. Magnetic resonance imaging, ultrasonography and histology of the suspensory ligament origin: a comparative study of normal anatomy of Warmblood horses.. Equine Vet J (2006) 38:508–16.
    doi: 10.2746/042516406X156109pubmed: 17124840google scholar: lookup
  53. Brokken MT, Schneider RK, Sampson SN, Tucker RL, Gavin PR, Ho CP. Use of magnetic resonance imaging to diagnose injuries in the proximal metacarpus and metatarsus in horses.. Proc Annu Conv Am Assoc Equine Pract (2007) 53:40–5.
  54. Werpy NM, Denoix JM, McllWraith CW, Frisbie DD. Comparison between standard ultrasonography, angle contrast ultrasonography, and magnetic resonance imaging characteristics of the normal equine proximal suspensory ligament.. Vet Radiol Ultrasound (2013) 54:536–47.
    doi: 10.1111/vru.12051pubmed: 23718137google scholar: lookup
  55. Schramme M, Josson A, Linder K. Characterization of the origin and body of the normal equine rear suspensory ligament using ultrasonography, magnetic resonance imaging, and histology.. Vet Radiol Ultrasound (2013) 53:318–28.
    doi: 10.1111/j.1740-8261.2011.01922.xpubmed: 22332890google scholar: lookup
  56. Routh J, Gilligan S, Strang C, Dyson S. Is there any association between strainght tarsus (hock) conformation and hindlimb proximal suspensory desmopathy?. Equine Vet J (2017) 49:17.
    doi: 10.1111/evj.28_12732google scholar: lookup

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    doi: 10.3390/ani15243586pubmed: 41463871google scholar: lookup
  2. Jacobs C, Schnabel LV, Redding Horne C, Tufts S, Martin EGM, Love K. Postoperative management following equine orthopedic surgery: a survey of diplomates of the ACVS and ACVSMR. Front Vet Sci 2025;12:1708401.
    doi: 10.3389/fvets.2025.1708401pubmed: 41427135google scholar: lookup
  3. Freeman KD, Adams MN, Salinger AE, White NA 2nd, Barrett JG. Comparison of Two Surgical Techniques for the Treatment of Equine Hindlimb Proximal Suspensory Desmopathy. Animals (Basel) 2025 Sep 4;15(17).
    doi: 10.3390/ani15172598pubmed: 40941393google scholar: lookup
  4. Banu SA, Sharun K, Emmanuel RS, Mamachan M, Manjusha KM, Muthu S, El-Husseiny HM, Kumar R, Pawde AM, Dhama K, Amarpal. Stem Cell Exosomes for Osteoarthritis in Veterinary Medicine. Stem Cells Int 2025;2025:4888569.
    doi: 10.1155/sci/4888569pubmed: 40704321google scholar: lookup
  5. Carmona JU, López C. Efficacy of Platelet-Rich Plasma in the Treatment of Equine Tendon and Ligament Injuries: A Systematic Review of Clinical and Experimental Studies. Vet Sci 2025 Apr 18;12(4).
    doi: 10.3390/vetsci12040382pubmed: 40284884google scholar: lookup
  6. Guerra-Gomes M, Ferreira-Baptista C, Barros J, Alves-Pimenta S, Gomes P, Colaço B. Exploring the Potential of Non-Cellular Orthobiologic Products in Regenerative Therapies for Stifle Joint Diseases in Companion Animals. Animals (Basel) 2025 Feb 18;15(4).
    doi: 10.3390/ani15040589pubmed: 40003071google scholar: lookup
  7. Guest DJ, Birch HL, Thorpe CT. A review of the equine suspensory ligament: Injury prone yet understudied. Equine Vet J 2025 Sep;57(5):1167-1182.
    doi: 10.1111/evj.14447pubmed: 39604165google scholar: lookup
  8. Carmona JU, Carmona-Ramírez LH, López C. Platelet-Rich Plasma and Related Orthobiologics for the Treatment of Equine Musculoskeletal Disorders-A Bibliometric Analysis from 2000 to 2024. Vet Sci 2024 Aug 21;11(8).
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