Effects of mosapride citrate, metoclopramide hydrochloride, lidocaine hydrochloride, and cisapride citrate on equine gastric emptying, small intestinal and caecal motility.
Abstract: Although extensive work has been done to elucidate the beneficial and unfavorable effects of gastrointestinal prokinetic agents in humans, little is known on the effects of these agents in horses. In this study, we compared the effects of mosapride, metoclopramide, cisapride, and lidocaine on equine gastric emptying, jejunal and caecal motility and evaluated these agents' adverse drug reactions (ADRs). Methods: Seven healthy adult Thoroughbreds. Methods: Mosapride 1.0mg/kg and 2.0mg/kg, metoclopramide 0.2mg/kg, and cisapride 1.0mg/kg were dissolved in 100mL distilled water for oral administration. Lidocaine 1.3mg/kg was mixed with 500 mL saline for a 30-min intravenous infusion. Oral administration of 100mL distilled water was used as control. Gastric emptying was evaluated using (13)CO(2) breath test, and jejunal and caecal motility was assessed by electrointestinography. Results: The present study demonstrates that mosapride at doses of 1.0mg/kg and 2.0mg/kg facilitates gastric emptying in horses. Improved jejunal motility was observed following administration of mosapride (1.0mg/kg and 2.0mg/kg), metoclopramide (0.2mg/kg), and cisapride (1.0mg/kg). Similarly, improved caecal motility was observed following administration of mosapride (2.0mg/kg). Conclusions: This study shows that among the prokinetic agents studied here, only mosapride (2.0mg/kg) promotes jejunal and caecal motility in horses. Considering mosapride ADRs profile, it is believed that this compound is useful in the treatment of diseases associated with decreased GI motility, including postoperative ileus.
Publication Date: 2008-08-23 PubMed ID: 18723200DOI: 10.1016/j.rvsc.2008.07.008Google Scholar: Lookup
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- Journal Article
Summary
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This research investigates how four different gastrointestinal prokinetic agents, previously mostly studied in humans, impact the gastric emptying and intestinal motility in horses. The study finds that mosapride, in particular, proves effective in facilitating gastric emptying and improving both jejunal and caecal motility.
Understanding the Study
- The purpose of this study is to analyze the effects of four prokinetic agents – mosapride citrate, metoclopramide hydrochloride, lidocaine hydrochloride, and cisapride citrate – on equine gastrointestinal functions.
- The agents are tested in different quantities, and their impacts on gastric emptying and intestinal motility are evaluated. These agents’ potential adverse drug reactions (ADRs) were also taken into account.
Methodology
- Seven healthy adult Thoroughbreds participated in the study. Various amounts of mosapride, metoclopramide, cisapride, and lidocaine were given to these horses.
- These agents were dissolved in distilled water for oral administration, with exception to lidocaine, which was mixed with saline for intravenous infusion.
- The experiment also involved a control setup where horses were only administered distilled water.
- Gastric emptying was observed using a (13)CO(2) breath test, whereas jejunal and caecal motilities were assessed through electrointestinography.
Findings
- The study found that mosapride in doses of 1.0mg/kg and 2.0mg/kg effectively facilitates gastric emptying in horses.
- Improved jejunal motility was seen after administration of 1.0mg/kg and 2.0mg/kg mosapride, 0.2mg/kg metoclopramide, and 1.0mg/kg cisapride.
- Improved caecal motility was seen after mosapride was administered at 2.0mg/kg.
- In comparison, of all the prokinetic agents involved in the study, only a 2.0mg/kg dosage of mosapride managed to promote both jejunal and caecal motilities.
Conclusion
- The study concludes that mosapride, considering its ADRs profile, is potentially beneficial in treating conditions related to decreased GI motility in horses, including postoperative ileus.
- This study therefore provides significant evidence to encourage further research into the use of mosapride for managing gastrointestinal health in horses.
Cite This Article
APA
Okamura K, Sasaki N, Yamada M, Yamada H, Inokuma H.
(2008).
Effects of mosapride citrate, metoclopramide hydrochloride, lidocaine hydrochloride, and cisapride citrate on equine gastric emptying, small intestinal and caecal motility.
Res Vet Sci, 86(2), 302-308.
https://doi.org/10.1016/j.rvsc.2008.07.008 Publication
Researcher Affiliations
- United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanago, Gifu-shi 501-1193, Japan.
MeSH Terms
- Animals
- Benzamides / pharmacology
- Breath Tests
- Carbon Isotopes
- Cisapride / pharmacology
- Female
- Gastric Emptying / drug effects
- Gastrointestinal Agents / pharmacology
- Horses / metabolism
- Lidocaine / pharmacology
- Male
- Metoclopramide / pharmacology
- Morpholines / pharmacology
Citations
This article has been cited 12 times.- Marzok M, Kandeel M, Alkhodair K, Abdel-Raheem S, Ismail H, Farag A, Ibrahim H, El-Ashkar M, Shousha S, El-Khodery S. Evaluation of cardiac indices using M-mode echocardiography after administration of metoclopramide and ondansetron in donkeys (Equus asinus): an experimental study. Front Vet Sci 2023;10:1189710.
- Patton ME, Andrews FM, Bogers SH, Wong D, McKenzie HC 3rd, Werre SR, Byron CR. Effects of Bit Chewing on Gastric Emptying, Small Intestinal Transit, and Orocecal Transit Times in Clinically Normal Horses. Animals (Basel) 2023 Aug 4;13(15).
- Beder NA, Mourad AA, Aly MA. Ultrasonographic evaluation of the effects of the administration of neostigmine and metoclopramide on duodenal, cecal, and colonic contractility in Arabian horses: A comparative study. Vet World 2020 Nov;13(11):2447-2451.
- Xu H, Xiong J, Xu J, Li S, Zhou Y, Chen D, Cai X, Ping J, Deng M, Chen J. Mosapride Stabilizes Intestinal Microbiota to Reduce Bacterial Translocation and Endotoxemia in CCl(4)-Induced Cirrhotic Rats. Dig Dis Sci 2017 Oct;62(10):2801-2811.
- Zhou J, Tang X, Wang J, Chen Z, Wang X, Jiang B. Feasibility of a novel low-volume and sodium phosphate-free bowel preparation regimen for colon capsule endoscopy. Exp Ther Med 2017 Aug;14(2):1739-1743.
- Salem SE, Proudman CJ, Archer DC. Has intravenous lidocaine improved the outcome in horses following surgical management of small intestinal lesions in a UK hospital population?. BMC Vet Res 2016 Jul 27;12(1):157.
- Wang SY, Liu YP, Fan YH, Zhang L, Cai LJ, Lv B. Mechanism of aqueous fructus aurantii immaturus extracts in neuroplexus of cathartic colons. World J Gastroenterol 2015 Aug 21;21(31):9358-66.
- Ida Y, Hosoe N, Imaeda H, Bessho R, Ichikawa R, Naganuma M, Kanai T, Hibi T, Ogata H. Effects of the oral administration of mosapride citrate on capsule endoscopy completion rate. Gut Liver 2012 Jul;6(3):339-43.
- Huerta-Franco MR, Vargas-Luna M, Montes-Frausto JB, Flores-Hernández C, Morales-Mata I. Electrical bioimpedance and other techniques for gastric emptying and motility evaluation. World J Gastrointest Pathophysiol 2012 Feb 15;3(1):10-8.
- Thampongsa T, Saengsawang B, Supsamutchai C, Wilasrusmee C, Jirasiritham J, Punmeechao P, Palitnonkiat V, Poprom N, Choikrua P, Singhathas P. The efficacy of mosapride on recovery of intestinal motility after elective colorectal cancer surgery: a randomized controlled trial. Ann Coloproctol 2025 Jun;41(3):232-238.
- Munsterman AS, Dias Moreira AS, Kottwitz J. Evaluation of the Effects of Detomidine on Equine Myoelectrical Activity Using Electrointestinography. J Vet Emerg Crit Care (San Antonio) 2025 Mar-Apr;35(2):120-130.
- Sousa LN, Winter IC, Varela DD, Luvison EZ, Guzmán JFC, Machado AMV, Figueiredo RDV, Pena GT, Dos Santos ACS, Faleiros RR, Carvalho AM. Lidocaine's Ineffectiveness in Mitigating Lipopolysaccharide-Induced Pain and Peristaltic Effects in Horses. Animals (Basel) 2024 Nov 2;14(21).
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