Effects of omeprazole on healing of naturally-occurring gastric ulcers in thoroughbred racehorses.
Abstract: Seventeen Thoroughbred horses with moderate to severe gastric ulceration were purchased from a race track within 10 days of racing and were treated once daily with either omeprazole (9 horses) or vehicle (8 horses) and evaluated gastroscopically for ulcer healing. Horses were administered omeprazole (1.5 mg/kg bwt/day) or vehicle by nasogastric tube once daily. Gastroscopic examination was performed on Days 0, 4, 7, 11, 14, 17, 21, 24 and 28, until lesions healed completely. Selected images of gastric lesions were captured by computer at each endoscopic examination, with a measuring caliper included in captured images. The area and perimeter of lesions were measured by computer and healing rates of specific lesions were determined by calculating the rate of linear advance of the margins toward the centre of the lesion. Additionally, the number of days to complete healing of the entire gastric squamous mucosa was compared between treatment groups. Gastric lesions healed at a significantly faster rate in horses receiving omeprazole than in vehicle-treated horses (P < 0.001). Complete healing of the entire stomach occurred in 10-21 days in omeprazole-treated horses, and 14-28 days in 3 of 8 vehicle-treated horses, with the remaining vehicle-treated horses having unhealed lesions on Day 28. In addition, 5 vehicle-treated horses developed new lesions in the squamous epithelial mucosa during the trial; no new lesions were observed in the omeprazole-treated group.
Publication Date: 1997-12-31 PubMed ID: 9413713DOI: 10.1111/j.2042-3306.1997.tb03153.xGoogle Scholar: Lookup
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- Clinical Trial
- Journal Article
- Randomized Controlled Trial
- Research Support
- Non-U.S. Gov't
Summary
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The research study focuses on observing the effects of omeprazole in the healing process of naturally-occurring gastric ulcers in racehorses. It found that omeprazole significantly accelerated the healing rate of gastric ulcers, with complete recovery taking place around 10-21 days.
Study Design and Methodology
- The study involved seventeen Thoroughbred racehorses, identified to have moderate to severe gastric ulcerations. These horses were chosen within ten days of racing and segregated into two groups, nine were given omeprazole, and the rest were given a placebo treatment.
- Omeprazole dosage was administered at 1.5 mg/kg body weight per day through a nasogastric tube.
- A thorough gastroscopic examination was carried out on the horses on various days (0, 4, 7, 11, 14, 17, 21, 24, and 28) until the gastric lesions were entirely healed.
- Computer images of the gastric lesions were secured at every endoscopic examination, and the area and perimeter of these lesions were measured.
Measurement of Healing and Results
- The healing rate of specific lesions was determined by calculating the speed at which the lesion margins moved towards the center.
- The total time taken for the healing of the gastric squamous mucosa was compared between the two groups under treatment.
- Results showed that the lesions healed a lot quicker in horses that received omeprazole than those who were given the vehicle. The statistical difference was found significant (P < 0.001).
- Complete healing of the stomach was seen in omeprazole-treated horses within 10 to 21 days.
Further Observations
- In horses treated with the vehicle, only three of eight showed full recovery between 14-28 days, while the rest still had unhealed lesions on the 28th day.
- Moreover, previously unobserved lesions appeared in the squamous epithelial mucosa in five vehicle-treated horses over the study period, while no new lesions were discovered in the omeprazole-treated ones.
Cite This Article
APA
Murray MJ, Haven ML, Eichorn ES, Zhang D, Eagleson J, Hickey GJ.
(1997).
Effects of omeprazole on healing of naturally-occurring gastric ulcers in thoroughbred racehorses.
Equine Vet J, 29(6), 425-429.
https://doi.org/10.1111/j.2042-3306.1997.tb03153.x Publication
Researcher Affiliations
- Marion duPont Scott Equine Medical Center, Leesburg, Virginia, USA.
MeSH Terms
- Animals
- Anti-Ulcer Agents / administration & dosage
- Anti-Ulcer Agents / therapeutic use
- Dose-Response Relationship, Drug
- Female
- Gastric Mucosa / pathology
- Gastroscopy / methods
- Gastroscopy / veterinary
- Horse Diseases / drug therapy
- Horse Diseases / pathology
- Horses
- Image Processing, Computer-Assisted
- Intubation, Gastrointestinal / veterinary
- Male
- Omeprazole / administration & dosage
- Omeprazole / therapeutic use
- Pharmaceutical Vehicles
- Severity of Illness Index
- Sports
- Stomach Ulcer / drug therapy
- Stomach Ulcer / pathology
- Stomach Ulcer / veterinary
- Time Factors
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