Effects of pharmacological agents on gastrointestinal motility.
Abstract: The control mechanisms of gastrointestinal motility are complex. Extrinsic neurohormonal effects modulate an intrinsic system, often called the "gut brain," composed of nervous and neuropeptide components. To exert pharmacologic influence on GI motility, use is made of agents that mimic the external control system. Agents that stimulate opioid receptors, block adrenoceptors, block or facilitate acetylcholine action, or antagonize the action of prostaglandins are used to effect changes in GI motility. The major indications for pharmacologic intervention are to increase motility in constipation, to reduce it in most cases of diarrhea, and to restore propulsive coordination in postoperative ileus. In cases of clinical colic the primary requirement is control of pain. Agents used for this purpose may adversely affect motility, and choice requires knowledge of their actions in this respect. In addition, drugs used for other purposes, anthelmintics for instance, may also influence gut motility. A synopsis of the actions of the agents commonly employed in GI motility control and some associated drugs are displayed in Table 3. Recent advances in the understanding of drug action on the gut should help in the selection of drugs for clinical use.
Publication Date: 1989-08-01 PubMed ID: 2670108DOI: 10.1016/s0749-0739(17)30589-8Google Scholar: Lookup
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Summary
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This study delves into the complex modulatory mechanisms of gastrointestinal (GI) motility and the impact of different pharmacological agents on it. The main focus of these agents are to stimulate or slow down GI motility or to restore balance in conditions where coordination has been disrupted, for instance, in constipation, diarrhea, and postoperative ileus.
Understanding Gastrointestinal Motility
- Gastrointestinal motility refers to the movement of the digestive system, i.e., the progression of the contents within it. It is imperative for normal digestive processes and is regulated by a complex system often referred to as the “gut brain”.
- The “gut brain”, an intricate network of nerves and neuropeptides, is primarily governed by extrinsic neurohormonal effects. The interactions of these physiological components decide the pace and direction of GI motility.
Role of Pharmacological Agents
- The study delves into the impact of certain pharmacological agents on GI motility. These agents aim to stimulate or slow down motility based on the desired therapeutic outcome.
- Agents work in multiple ways, some mimic the external control system. Some stimulate opioid receptors, block adrenoceptors or acetylcholine action, or counter the action of prostaglandins to bring about desired changes in GI motility.
- The reason for using these agents varies. In some cases, the goal is to increase motility (for example, in treating constipation), in others, it’s to reduce motility (as in treating diarrhea), and in yet others, it’s to restore the propulsive coordination lost due to postoperative ileus.
Selection and Adverse Effects of Pharmacological Agents
- It’s important to carefully select the appropriate agent for a given condition. Some agents that are used to control pain, especially in cases of clinical colic, may negatively affect motility. Their selection requires thorough consideration of their potential impact on motility.
- Besides, certain drugs used for other purposes, such as anthelmintics, might also impact gut motility and should be used after weighing their potential benefits against risks.
Synopsis of Comprehensive Actions
- The study provides a summary of the actions of routinely used agents in GI motility control, along with some related drugs. This summary can assist clinicians in making informed decisions about the appropriate drug for a specific condition.
- Understanding of drug action on the gut has significantly improved in recent times, which can be advantageous in the process of drug selection for clinical use.
Cite This Article
APA
Gerring EL.
(1989).
Effects of pharmacological agents on gastrointestinal motility.
Vet Clin North Am Equine Pract, 5(2), 283-294.
https://doi.org/10.1016/s0749-0739(17)30589-8 Publication
Researcher Affiliations
- Department of Surgery and Obstetrics, Royal Veterinary College, Hatfield, Herts, United Kingdom.
MeSH Terms
- Animals
- Colic / drug therapy
- Colic / veterinary
- Constipation / drug therapy
- Constipation / veterinary
- Diarrhea / drug therapy
- Diarrhea / veterinary
- Gastrointestinal Motility / drug effects
- Horse Diseases / drug therapy
- Horses / physiology
- Intestinal Obstruction / drug therapy
- Intestinal Obstruction / veterinary
Citations
This article has been cited 2 times.- Navarre CB, Roussel AJ. Gastrointestinal motility and disease in large animals. J Vet Intern Med 1996 Mar-Apr;10(2):51-9.
- Kassaw KI, Wondafrash DZ, Yesuf JS, Mengistie MG. Evaluation of the antidiarrheal activity of the 80% hydromethanolic crude extract and solvent fractions of Terminalia brownii Fresen (Combretaceae) leaves in Swiss Albino mice. Front Pharmacol 2024;15:1510171.
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