Effects of treatment with and without adjuvant radiation therapy on recurrence of ocular and adnexal squamous cell carcinoma in horses: 157 cases (1985-2002).
Abstract: To determine the effects of treatment with and without adjuvant radiation therapy on recurrence of ocular and adnexal squamous cell carcinoma (SCC) at specific anatomic locations in horses. Methods: Retrospective study. Methods: 91 horses. Methods: Medical records of horses with histologically confirmed ocular and adnexal SCC evaluated from 1985 to 2002 were reviewed. Sex, breed, age, type of treatment, location, and recurrence of SCC were recorded. Two treatment groups determined by recurrence of SCCs treated with and without adjuvant radiation therapy were established. Results: The anatomic site with the highest recurrence rate was the limbus (junction of the cornea and sclera) or bulbar conjunctiva (477%), independent of treatment group. There was a significant difference in recurrence rates of ocular and adnexal SCCs between the 2 treatment groups, independent of anatomic location. Recurrence rates of SCCs treated with and without adjuvant radiation therapy were 11.9% and 44.1%, respectively. Recurrence rates for SCCs of the eyelid, limbus or bulbar conjunctiva, and cornea treated with adjuvant radiation therapy were significantly different from those for SCCs treated without adjuvant radiation therapy. The most frequently represented anatomic site for ocular and adnexal SCCs was the eyelid (28.7%). Coat color, breed, and the interaction of age and breed had a significant effect on tumor recurrence regardless of treatment type and anatomic location. Conclusions: Results indicated that ocular and adnexal SCCs treated with adjuvant radiation therapy had a significantly lower recurrence rate, compared with SCCs treated without adjuvant radiation therapy, independent of anatomic location.
Publication Date: 2005-01-01 PubMed ID: 15626225DOI: 10.2460/javma.2004.225.1733Google Scholar: Lookup
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Summary
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This research study focuses on the impact of treatments, with and without adjunctive radiation therapy, on the recurrence of eye and adnexal squamous cell carcinoma (SCC) in horses. The study found that horses treated with adjuvant radiation therapy had a significantly lower recurrence rate of SCC, regardless of where the SCC was located.
Overview of the Study
- The study was a retrospective study carried out on 91 horses. The study period ranged from 1985 to 2002.
- The horses had histologically confirmed eye and adnexal SCC. Various factors such as sex, breed, age, type of treatment, location, and recurrence of SCC were recorded.
- Two treatment groups were established, based on the recurrence of SCCs treated with and without adjuvant radiation therapy.
Findings of the Study
- The area with the highest recurrence rate was the limbus (the junction of the cornea and sclera) or bulbar conjunctiva, regardless of the treatment group.
- The study revealed significant differences in recurrence rates of ocular and adnexal SCCs between the two treatment groups, regardless of where the SCC was located.
- SCCs treated with adjuvant radiation therapy had a lower recurrence rate (11.9%) compared to SCCs treated without adjuvant radiation therapy (44.1%).
- Recurrence rates of SCCs in the eyelid, limbus or bulbar conjunctiva, and cornea treated with radiation therapy were significantly lower in comparison to SCCs treated without adjuvant radiation therapy.
- The eyelid was the most frequently represented anatomical site for ocular and adnexal SCCs, present in 28.7% of cases.
- Factors such as coat color, breed, and the interaction of age and breed significantly influenced tumor recurrence, regardless of the treatment type and anatomic location.
Conclusion of the Study
- The study concluded that adjuvant radiation therapy significantly reduces the recurrence rate of ocular and adnexal SCCs in horses, regardless of the anatomical location of the SCC.
Cite This Article
APA
Mosunic CB, Moore PA, Carmicheal KP, Chandler MJ, Vidyashankar A, Zhao Y, Roberts RE, Dietrich UM.
(2005).
Effects of treatment with and without adjuvant radiation therapy on recurrence of ocular and adnexal squamous cell carcinoma in horses: 157 cases (1985-2002).
J Am Vet Med Assoc, 225(11), 1733-1738.
https://doi.org/10.2460/javma.2004.225.1733 Publication
Researcher Affiliations
- Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30602-7371, USA.
MeSH Terms
- Animals
- Carcinoma, Squamous Cell / radiotherapy
- Carcinoma, Squamous Cell / surgery
- Carcinoma, Squamous Cell / veterinary
- Eye Neoplasms / radiotherapy
- Eye Neoplasms / surgery
- Eye Neoplasms / veterinary
- Female
- Horse Diseases / radiotherapy
- Horse Diseases / surgery
- Horses
- Male
- Neoplasm Recurrence, Local / prevention & control
- Neoplasm Recurrence, Local / veterinary
- Prognosis
- Radiotherapy, Adjuvant / veterinary
- Retrospective Studies
- Survival Analysis
Citations
This article has been cited 8 times.- Ng ATJ, McMullen RJ Jr, Shaw GC, Passler T, Stockler J. Limbal Squamous Cell Carcinoma in a Black Baldy Cow: Case Report and Surgical Treatment.. Case Rep Vet Med 2023;2023:2429241.
- Wotman KL, Chow L, Martabano B, Pezzanite LM, Dow S. Novel ocular immunotherapy induces tumor regression in an equine model of ocular surface squamous neoplasia.. Cancer Immunol Immunother 2023 May;72(5):1185-1198.
- Horvath S, Haghani A, Peng S, Hales EN, Zoller JA, Raj K, Larison B, Robeck TR, Petersen JL, Bellone RR, Finno CJ. DNA methylation aging and transcriptomic studies in horses.. Nat Commun 2022 Jan 10;13(1):40.
- Spugnini EP, Scacco L, Bolaffio C, Baldi A. Electrochemotherapy for the treatment of cutaneous solid tumors in equids: A retrospective study.. Open Vet J 2021 Jul-Sep;11(3):385-389.
- Crausaz M, Launois T, Smith-Fleming K, McCoy AM, Knickelbein KE, Bellone RR. DDB2 Genetic Risk Factor for Ocular Squamous Cell Carcinoma Identified in Three Additional Horse Breeds.. Genes (Basel) 2020 Dec 5;11(12).
- Levitt S, Osinchuk S, Sandmeyer L. Diagnostic Ophthalmology.. Can Vet J 2020 Jul;61(7):789-791.
- Singer-Berk MH, Knickelbein KE, Lounsberry ZT, Crausaz M, Vig S, Joshi N, Britton M, Settles ML, Reilly CM, Bentley E, Nunnery C, Dwyer A, Lassaline ME, Bellone RR. Additional Evidence for DDB2 T338M as a Genetic Risk Factor for Ocular Squamous Cell Carcinoma in Horses.. Int J Genomics 2019;2019:3610965.
- Jeanes EC, Koll-Hampp S, Dawson C, Dunkel B, Tetas Pont R. Rhomboid blepharoplasty and cryotherapy for the treatment of a squamous cell carcinoma on the lower eyelid in a horse.. Clin Case Rep 2019 Jan;7(1):40-46.
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