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Home / Equine Research Bank / J Vet Intern Med / Efficacy of tamoxifen for the treatment of severe equine ast...
Journal of veterinary internal medicine2018; 32(5); 1748-1753; doi: 10.1111/jvim.15289

Efficacy of tamoxifen for the treatment of severe equine asthma.

Abstract: Tamoxifen, a selective estrogen receptor modulator, decreased airway neutrophilia and improved clinical signs in an experimental model of equine asthma, and induced neutrophilic apoptosis in vitro. Objective: Tamoxifen reduces airway neutrophilia and improves lung function in severe asthmatic horses. Methods: Twelve severe asthmatic horses from a research herd. Methods: Randomized controlled blinded study design. The effects of a 12-day oral treatment with tamoxifen (0.22 mg/kg, q24h) or dexamethasone (0.06 mg/kg, q24h) on lung function, endoscopic tracheal mucus score and bronchoalveolar lavage fluid cytology were compared. Results: Tamoxifen significantly improved the pulmonary resistance (R ; mean reduction of 1.15 cm H O/L/s [CI: 0.29-2.01, P = .007] on day 13), but had no effect on the other variables evaluated. Dexamethasone normalized lung function (mean reduction of R of 2.48 cm H O/L/s [CI: 1.54-3.43, P < .0001] on day 13), without affecting airway neutrophilia. Conclusions: Results of this study do not support the use of tamoxifen at the dose studied as an antineutrophilic medication in the treatment of asthmatic horses in chronic exacerbation.
© 2018 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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Publication Date: 2018-08-07 PubMed ID: 30084157PubMed Central: PMC6189378DOI: 10.1111/jvim.15289Google Scholar: Lookup
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  • Clinical Trial
  • Veterinary
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper investigates the effectiveness of a medication called tamoxifen in treating severe asthma in horses. It finds that while tamoxifen assists in reducing instances of neutrophilia- an increase in neutrophil concentration which is usually a reaction to inflammation- in the airways, it does not significantly affect other variables related to asthma.

Objective and Methodology

  • The main objective of this study was to understand if tamoxifen, a selective estrogen receptor modulator, can aid in reducing airway neutrophilia, thereby improving lung function in horses with severe asthma. In simpler terms, the goal was to explore if tamoxifen could help decrease inflammation in the airways of horses and thus, improve their breathing.
  • The study used 12 asthmatic horses from a research herd and employed a randomized, controlled, blinded design. This design ensures no bias or external influence would impact their research, providing for an objective and accurate assessment.
  • The researchers then compared the effects of a 12-day oral treatment with tamoxifen with a similar treatment course using dexamethasone, another anti-inflammatory drug. The comparison involved assessing the lung function, endoscopic tracheal mucus score, and the changes in the cellular composition of the bronchoalveolar lavage fluid (BALF), which is a tool to visualize lung inflammation.

Results

  • The administration of tamoxifen led to significant improvements in terms of pulmonary resistance. However, it didn’t impact any other variables studied.
  • On the other hand, Dexamethasone managed to normalize lung function without making any considerable difference to the airway neutrophilia.

Conclusions

  • The research concluded that the dose of tamoxifen studied did not have a substantial antineutrophilic effect in treating asthma in horses experiencing chronic exacerbation.
  • The researchers, therefore, do not recommend the usage of tamoxifen in the given dose as a medication for treating horses with asthma.

Cite This Article

APA
Mainguy-Seers S, Picotte K, Lavoie JP. (2018). Efficacy of tamoxifen for the treatment of severe equine asthma. J Vet Intern Med, 32(5), 1748-1753. https://doi.org/10.1111/jvim.15289

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 32
Issue: 5
Pages: 1748-1753

Researcher Affiliations

Mainguy-Seers, Sophie
  • Faculty of Veterinary Medicine, Department of Clinical Sciences, Université de Montréal, St-Hyacinthe, QC, Canada.
Picotte, Khristine
  • Faculty of Veterinary Medicine, Department of Clinical Sciences, Université de Montréal, St-Hyacinthe, QC, Canada.
Lavoie, Jean-Pierre
  • Faculty of Veterinary Medicine, Department of Clinical Sciences, Université de Montréal, St-Hyacinthe, QC, Canada.

MeSH Terms

  • Animals
  • Asthma / drug therapy
  • Asthma / veterinary
  • Bronchoalveolar Lavage Fluid / cytology
  • Female
  • Horse Diseases / drug therapy
  • Horses
  • Male
  • Random Allocation
  • Selective Estrogen Receptor Modulators / therapeutic use
  • Tamoxifen / therapeutic use

Grant Funding

  • Canadian Institutes of Health Research
  • Equine Research Fund of the Universitu00e9 de Montru00e9al (unrestricted grant from Zoetis)

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Citations

This article has been cited 6 times.
  1. Salinas C, Barriga K, Albornoz A, Alarcon P, Quiroga J, Uberti B, Sarmiento J, Henriquez C, Ehrenfeld P, Burgos RA, Moran G. Tamoxifen triggers the in vitro release of neutrophil extracellular traps in healthy horses.. Front Vet Sci 2022;9:1025249.
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  2. Mainguy-Seers S, Diaw M, Lavoie JP. Lung Function Variation during the Estrus Cycle of Mares Affected by Severe Asthma.. Animals (Basel) 2022 Feb 17;12(4).
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  4. Mainguy-Seers S, Lavoie JP. Glucocorticoid treatment in horses with asthma: A narrative review.. J Vet Intern Med 2021 Jul;35(4):2045-2057.
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