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Home / Equine Research Bank / Equine Vet J / Efficacy of vaccination against equine herpesvirus type 1 (E...
Equine veterinary journal2022; 55(3); 389-404; doi: 10.1111/evj.13870

Efficacy of vaccination against equine herpesvirus type 1 (EHV-1) infection: Systematic review and meta-analysis of randomised controlled challenge trials.

Abstract: Equid herpesvirus type 1 (EHV-1) infection can cause a range of disease syndromes of variable severity that can result in a lethal outcome and restriction of horse movements, especially in the case of outbreaks involving neurological disease. Vaccination is one of the tools used to control the infection. It is widely known that vaccination is not completely effective in ensuring protection against disease caused by this virus. In fact, the real efficacy of vaccination against EHV-1 related disease has not been measured and no systematic reviews exist on this topic. Objective: To perform a systematic review and meta-analysis on the efficacy of commercial or candidate vaccines against EHV-1 in randomised controlled trials (RCT) all of which involved experimental challenge of the test subjects. Methods: Systematic review and meta-analysis. Methods: RCTs were searched using the search algorithm (([equid herpesvirus* OR equine herpesvirus* OR EHV-1]) AND vaccin*) AND (trial OR experimental OR challenge) on PubMed, Science Citation Index Expanded, Scopus, and CAB Abstracts. Where appropriate, meta-analysis was performed using RevMan 5.4. Results: Eight studies were selected and were analysed for their respective characteristics and possible shortcomings. The results of RCTs revealed that there was a general improvement in the clinical and virological outcomes of EHV-1 infection following vaccination, but that the effects were very slight. The reduced beneficial effect is probably amplified by the paucity of detailed data reported in the studies that did not allow for the comparison of parameters in many of the cases analysed. Conclusions: The remarkable heterogeneity and the poor quality of reporting of the selected studies. Conclusions: Meta-analysis has shown that EHV-1 vaccination generally results in a slight improvement in clinical and virological outcomes, although not to a significant extent. The cumulative results have probably been affected by the lack of information on some parameters not systematically reported in the studies. An improvement in the standard of reporting and better standardisation of the data collected would likely have improved the quality of each study and enabled more effective comparison of the studies with each other.
© 2022 The Authors. Equine Veterinary Journal published by John Wiley & Sons Ltd on behalf of EVJ Ltd.
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Publication Date: 2022-08-31 PubMed ID: 35946376DOI: 10.1111/evj.13870Google Scholar: Lookup
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  • Meta-Analysis
  • Systematic Review
  • Journal Article
  • Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The article explores the effectiveness of vaccines in controlling the Equid herpesvirus type 1 (EHV-1) infection in horses. It involves a systematic review and meta-analysis of randomised controlled trials, revealing that while some improvement is seen after vaccination, the effects are minimal.

Research Objective

This meta-analysis sought to measure the real efficacy of commercial or candidate vaccines against EHV-1 through a systematic review of randomized controlled trials (RCTs). All the RCTs involved experimental challenges to the test subjects.

Methodology

The researchers used a systematic review and meta-analysis method to ascertain the efficacy of vaccines against EHV-1.

  • RCTs were researched using a search algorithm that included various iterations of equine herpesvirus and vaccination terms.
  • The search was done in multiple sources, namely PubMed, Science Citation Index Expanded, Scopus, and CAB Abstracts.
  • The researchers then performed a meta-analysis on the gathered data using RevMan 5.4 software.

Findings

On analyzing the gathered data:

  • Eight studies were selected and analyzed for their characteristics and possible shortcomings.
  • It was found that there was a slight overall improvement in the clinical and virological outcomes of EHV-1 infection after vaccination.
  • However, the study also points out that the beneficial effects were limited and that the scarcity of detailed data in the studies possibly amplified this reduced effect.

Conclusion

The study concludes:

  • Despite some heterogeneity and the poor quality of reporting, the meta-analysis suggests that EHV-1 vaccination results in only a minor improvement in clinical and virological outcomes.
  • The lack of systematically reported parameters in the studies probably affected the cumulative results.
  • There’s a call for an improvement in reporting standards and better standardization of collected data, which would heighten the study quality and enable more effective comparisons.

Cite This Article

APA
Marenzoni ML, De Waure C, Timoney PJ. (2022). Efficacy of vaccination against equine herpesvirus type 1 (EHV-1) infection: Systematic review and meta-analysis of randomised controlled challenge trials. Equine Vet J, 55(3), 389-404. https://doi.org/10.1111/evj.13870

Publication

Equine veterinary journal
ISSN: 2042-3306
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 55
Issue: 3
Pages: 389-404

Researcher Affiliations

Marenzoni, Maria Luisa
  • Department of Veterinary Medicine, University of Perugia, Perugia, Italy.
De Waure, Chiara
  • Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Timoney, Peter J
  • Department of Veterinary Science, Maxwell H. Gluck Equine Research Center, Lexington, Kentucky, USA.

MeSH Terms

  • Animals
  • Horses
  • Herpesvirus 1, Equid
  • Herpesvirus Vaccines / therapeutic use
  • Antibodies, Viral
  • Vaccination / veterinary
  • Herpesviridae Infections / prevention & control
  • Herpesviridae Infections / veterinary
  • Horse Diseases / prevention & control

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